aspies are stereotypically a very computer literate bunch, and there probably IS truth in that stereotype, so my answer is thus:
NOT VISTA....
vista adds a load of fool proof crap that annoys the computer literate, you put a CD in, a screen pops up saying "what do you want windows to do?" with a list filled with "play CD, copy CD, make some toast, show me some seizure inducing screen savers, blog this CD on myfacetwit, whatever".....I WANT WINDOWS TO DO NOTHING, JUST SIT THERE, UNTIL I GO TO "MY COMPUTER" CLICK ON THE CD ICON AND TELL YOU TO F***ING PLAY IT!
you click on a program icon and it says "are you sure you want windows to run this program?" YO MOTHERF***ER, I DOUBLE-CLICKED THAT ICON, OF COURSE I WANT TO F***ING RUN THE PROGRAM!
but at least it looks pretty i guess...
me, i miss amiga workbench...it looked ok, was perfectly functional and ran in about 1mb of memory...x