seroquel and remeron are anti-anxiety meds, i think....my aspies troubles with sleep revolve around not being able to sleep because of anxious, repetitive worry. hubby still wakes up in the middle of the night periodically...i wish there was something that worked universally, but that's not the way things are. you could always check into a sleep study. it would help rule out other reasons for waking up in the middle of the night. hubby's sleep study ruled out : Sleep Apnea, and Restless Leg Syndrome.