Status in HS is a zero-sum game so if status is a goal of yours, anyone you can put under the bus elevates you. Sadly, that means that the kids on the margins themselves have the most to gain in putting your son in the lowest social place they can. They treat the paradigm as a given, b/c in essence it is. If it wasn't your son having rode the special ed bus in lower elementary it would be someone elses kid for peeing in his pants in Kinder or something.
So, yes, it won't end until he goes somewhere else and it starts over. Luckily college is not as status-oriented in that there are kids who opt out of that cr**, and they can usually be found readily, especially if you avoid frats and sororities. (**Disclaimer--I know there are frats and sororities that are not like that, but hanging with independents is a really great way to avoid that kind of nonsense and anyone in frats or sororities who will hang with an independent with dubious social standing is likely to be OK, too. If you rush, you run the risk of dealing with a lot of nonsense and possibly bullying. (JMHO))