Agh, there's too many I'm interested in right now.
The biggest one is probably Dungeon of the Endless; it's like that game was designed specifically for me. It then also sold extremely well, got a bazillion bits of optional DLC (for a game like this, it's a good thing, as the DLC is done right), and even has an iOS version. It's also freaking gorgeous. Roguelike/strategy/tower-defense that manages to be a combination of turn-based and real-time. Sounds nonsensical on paper, but then, alot of my favorite games usually do. It's also tough as nails with a learning curve from hell. That being said, I beat it for the first time last night. Of course with that type of game, it's got way more pain for you after that. I'll be playing this alot. So much depth, content, and replay value.
In addition, there's Isaac of course, which at this point I consider to be one of the best games ever, particularly after the recent expansion added a ridiculous amount of modding capability, so I can make the game into what *I* want it to be.
Also an action roguelike called Unexplored, I'm going to be helping the devs of this one with closed-version testing now. Sometimes I wonder at the string of events that keeps leading to me doing stuff like that. No complaints though, it's easily one of my favorite games of the last couple years, in a favorite genre no less.
And of course 20XX, which I never lose interest in. The devs of Mighty No. 9 could have learned so much just from watching this one.
And others. Too many right now.