Spoilers ahead!
Just finished my first playthrough of Prey (2017). It's certainly worthy of it's Immersive Sim predecessors. Easily hangs with System Shock series, though less body horror and less creepy. Perhaps not quite as big on ideas as Deus Ex, but definitely enough.
It is probably the most interactive game in the genre to date, and the nicest looking.
I didn't spoil my experience too much so I did what I thought was the good ending. I did the command shuttle escape and no Typhon mods (I thought those would prevent a "good ending"). In the ending scene all of the operator comments were positive, and my end stats showed human kills at 0 and 17 saved (I might have had 3 mind-controlled people walk into a fire off-screen, but that was entirely beyond my control as that fire was there before I visited that area). I'll need to check to see what the highest number is.
I was suspecting the simulation plot twist, but I wasn't expecting to see Earth consumed by aliens.
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According to a quick Google search, 21 seems to be the maximum people saved, I think it's definitely the 3 that walked into a fire themselves, and I think the 4th one is the one in quarantine early in the game. I came back to check quarantine later after killing a bunch of telepaths, but this person had vanished from the quarantine cell and were nowhere to be found. At least that's what I think it is.