I hugely recommend Katawa Shoujo. It's technically a dating sim, but that's just the backdrop and game style. It's actually a heartwarming character study of various girls with pretty harsh disabilities. How they cope with them, and how despite it affecting their lives and making them different from yours or mine, they're normal people who aren't defined by their disability. Also a study into the main character's own disability, arguably worse than any of the others, and how his relationship with *insert girl of your choice* helps him learn to cope with his own.
There's some sexual content, which I wasn't really interested in. I have various fetishes, but on the act itself verge on asexuality. But, said sexual content is framed as loving, tender moments. The emotional interplay is fun to read, you can skip past the graphic parts if you're like me and bored by it.
_________________
Don't believe the gender tag. I was born intersex and identify as queer, girl-leaning. So while I can sometimes present as an effeminate guy, that's less than half the time and if anything I'd prefer it say "female" of the two choices offered. I can't change it though, it's bugged.