Dude, I can't even imagine how bad a game would be if it was based around having Asperger's Syndrome. Think about it.
You know how in The Sims, if you don't turn off "Free Will" then the Sims make horrible social decisions? An AS game would be like that...except you couldn't turn off "Free Will" mode. XD
Seriously, though. Imagine if there was a decent game with a protagonist who had Asperger's. A game that didn't have it be its central gameplay gimmick, but rather have it as a theme, with the character having it, and having to rise up to save the world even though the only way to do that would be to face the very difficulties that his disability entails?
Hmm. I'm not sure how that'd work. Any thoughts?