Haven't played any of the games too extensively (so I can't really vote for one), but I must admit, they're really fun for being sports games. I saw the first one for NES at Goodwill and had to snatch it up =)
Don't really care for the later sequels that came out for SNES and Genesis...16 plays is a bit too much for someone like me who's more into the arcade action of the game...I don't know anything about football plays, just let me pick one at random and hope it works
I'm pretty excited about the new game coming out for DS (I think it's hitting the Wii too? I'm not sure). Very oldskool, they even went back to eight plays. Shame they couldn't get the licenses to use real teams and players, but it looks like we'll be able to create/download our own =)
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I'll brave the storm to come, for it surely looks like rain...