This is going to be a controversial one, as I know how popular this game is, but for me? Okami.
I find it lacks something, like a layer is missing- the emotional one, for me. And, call me a big old girly gamer, but I can't get really immersed in a game if I don't feel compelled to save the day.
It's strange, I find Japanese folklore and fairytale completely absorbing, I love them, but Okami just leaves me cold.