Adverse Events After Routine Immunization of Extremely Low-B

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Results Most of the 13 926 infants (91.2%) received 3 or more immunizations. The incidence of sepsis evaluations increased from 5.4 per 1000 patient-days in the preimmunization period to 19.3 per 1000 patient-days in the postimmunization period (adjusted rate ratio [ARR], 3.7; 95% CI, 3.2-4.4). The need for increased respiratory support increased from 6.6 per 1000 patient-days in the preimmunization period to 14.0 per 1000 patient-days in the postimmunization period (ARR, 2.1; 95% CI, 1.9-2.5), and intubation increased from 2.0 per 1000 patient-days to 3.6 per 1000 patient-days (ARR, 1.7; 95% CI, 1.3-2.2). The postimmunization incidence of adverse events was similar across immunization types, including combination vaccines when compared with single-dose vaccines. Infants who were born at 23 to 24 weeks’ gestation had a higher risk of sepsis evaluation and intubation after immunization. A prior history of sepsis was associated with higher risk of sepsis evaluation after immunization.

--DeMeo SD, Raman SR, Hornik CP, Wilson CC, Clark R, Smith P. Adverse Events After Routine Immunization of Extremely Low-Birth-Weight Infants. JAMA Pediatr. Published online June 01, 2015. doi:10.1001/jamapediatrics.2015.0418. Retrieved from http://archpedi.jamanetwork.com/article ... id=2300376

Conclusions and Relevance All ELBW [extremely low-birth-weight] infants in the NICU [neonatal intensive care unit] had an increased incidence of sepsis evaluations and increased respiratory support and intubation after routine immunization. Our findings provide no evidence to suggest that physicians should not use combination vaccines in ELBW infants. Further studies are needed to determine whether timing or spacing of immunization administrations confers risk for the developing adverse events and whether a prior history of sepsis confers risk for an altered immune response in ELBW infants.

The Journal of the American Medical Association, Pediatrics, published this month an "Original Investigation" research paper which verified not only the risks of vaccine-induced adverse events among low-birth-weight infants, but, also confirmed the callous attitude of the medical community to the harm their rigid vaccine schedule has inflicted.