CDC Cover-up?
08 Sep 2014, 9:10 am
btbnnyr wrote:
Interpreting scientific research results works like this: Specific result needs to pop up again and again and again to be considered close to the truth, eggspecially if the result is about something as mechanistically ill-defined as autism causation. A single significant finding a single time means not much, while the same significant finding multiple times means something. Just this summer, I had a problem with some data that some people turned into nonsense by processing it wrong, and that resulted in a p ~ 0.003 significant correlation of absolute nonsense.
I didn't read this whole thread, but I just need to post this about how science research works.
I didn't read this whole thread, but I just need to post this about how science research works.
What about the "accelerated approval" criteria http://www.forbes.com/sites/johnlamatti ... oo-quickly for "breakthrough therapy" designation http://www.fda.gov/regulatoryinformatio ... 341027.htm and fast-track designation https://en.wikipedia.org/wiki/FDA_Fast_ ... nt_Program where "because we say so" (and not recreating results "again and again and again") might govern the expedited outcome of certain drugs and therapies? Couldn't this system (as rigorous as it appears to be) be abused especially with lobbying by the pharmaceutical industry that stands to gain financially and legally (such as patents) from an earlier release date than normal?
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Diagnosed in 2015 with ASD Level 1 by the University of Utah Health Care Autism Spectrum Disorder Clinic using the ADOS-2 Module 4 assessment instrument [11/30] -- Screened in 2014 with ASD by using the University of Cambridge Autism Research Centre AQ (Adult) [43/50]; EQ-60 for adults [11/80]; FQ [43/135]; SQ (Adult) [130/150] self-reported screening inventories -- Assessed since 1978 with an estimated IQ [≈145] by several clinicians -- Contact on WrongPlanet.net by private message (PM)
08 Sep 2014, 9:34 am
AspieUtah wrote:
btbnnyr wrote:
Interpreting scientific research results works like this: Specific result needs to pop up again and again and again to be considered close to the truth, eggspecially if the result is about something as mechanistically ill-defined as autism causation. A single significant finding a single time means not much, while the same significant finding multiple times means something. Just this summer, I had a problem with some data that some people turned into nonsense by processing it wrong, and that resulted in a p ~ 0.003 significant correlation of absolute nonsense.
I didn't read this whole thread, but I just need to post this about how science research works.
I didn't read this whole thread, but I just need to post this about how science research works.
What about the "accelerated approval" criteria http://www.forbes.com/sites/johnlamatti ... oo-quickly for "breakthrough therapy" designation http://www.fda.gov/regulatoryinformatio ... 341027.htm and fast-track designation https://en.wikipedia.org/wiki/FDA_Fast_ ... nt_Program where "because we say so" (and not recreating results "again and again and again") might govern the expedited outcome of certain drugs and therapies? Couldn't this system (as rigorous as it appears to be) be abused especially with lobbying by the pharmaceutical industry that stands to gain financially and legally (such as patents) from an earlier release date than normal?
Those things are really irrelevant to the topic: is the CDC covering up proof that vaccines cause autism?
Those are government guidelines, not science. Further, fda guidelines are far reaching and have nothing to do with the topic.
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sonofghandi
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08 Sep 2014, 9:38 am
AspieUtah wrote:
What about the "accelerated approval" criteria http://www.forbes.com/sites/johnlamatti ... oo-quickly for "breakthrough therapy" designation http://www.fda.gov/regulatoryinformatio ... 341027.htm and fast-track designation https://en.wikipedia.org/wiki/FDA_Fast_ ... nt_Program where "because we say so" (and not recreating results "again and again and again") might govern the expedited outcome of certain drugs and therapies? Couldn't this system (as rigorous as it appears to be) be abused especially with lobbying by the pharmaceutical industry that stands to gain financially and legally (such as patents) from an earlier release date than normal?
Alot of things wrong with your assumptions here, so I'll be very brief and sum up a few.
Fast tracking FDA approval is rare and not an easy thing to even be considered. The drug being approved needs to show extremely beneficial results treating a condition where time is an immediate concern for health consequences (almost always terminal conditions) AND there is a need for it currently unmet AND there are no alternative treatments. It also still needs to meet all criteria even after approved; it isn't a one and done process. It is more often along the lines of receiving front of the line priviledges. As for abuse, I suppose it is possible, but not very easy to accomplish, given the strict requirements to even be considered. As for patents, those usually come long before being approved, often before any clinical trials even begin.
You seem to spend a significant amount of time trying to discredit the scientific process and scientific studies, yet you rely on a scant few tidbits from a very tiny few people for your arguments. When your reasoning relies almost entirely on conspiracy theories and trying to discredit large amounts of hard data and scientific findings, you may want to reconsider your line of debate.
As it stands, even if you use the faulty statistical model and previously omitted data used by your references, it still proves that Wakefield could not possibly have been honest in his paper, as his sample is all white, and the data (which still does not have an acceptable p value to be considered significant) would only show a "correlation" between black children without birth certificates being diagnosed around the same time as vaccination (which even then has a lack of demonstrable causation). MMR vaccines do not cause autism any more than HPV vaccines cause increased teen pregnancy rates (another thing that big bad pharma supposedly is covering up).
The arguing about vaccines was always "mercury! mercury!" until they stopped using it with no change and then it was suddenly "allergic reactions!" or "inflammation!" or "brain damage!"
If your assumptions are proven wrong, assuming that they are right by looking desperately for new "proof" will only net you psuedoscience and a complete lack of critical thinking.
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08 Sep 2014, 10:53 am
sonofghandi wrote:
...even if you use the faulty statistical model and previously omitted data used by your references, it still proves that Wakefield could not possibly have been honest in his paper....
Did I refer to Andrew J. Wakefield, MB, BS, FRCS, FRCPath, in my statement and questions about U.S. federal "accelerated approval" of drugs and therapies?
I didn't think so.
_________________
Diagnosed in 2015 with ASD Level 1 by the University of Utah Health Care Autism Spectrum Disorder Clinic using the ADOS-2 Module 4 assessment instrument [11/30] -- Screened in 2014 with ASD by using the University of Cambridge Autism Research Centre AQ (Adult) [43/50]; EQ-60 for adults [11/80]; FQ [43/135]; SQ (Adult) [130/150] self-reported screening inventories -- Assessed since 1978 with an estimated IQ [≈145] by several clinicians -- Contact on WrongPlanet.net by private message (PM)
08 Sep 2014, 11:06 am
AspieUtah wrote:
Did I refer to Andrew J. Wakefield, MB, BS, FRCS, FRCPath, in my statement and questions about U.S. federal "accelerated approval" of drugs and therapies?
I didn't think so.
I didn't think so.
You have, however, referenced it (if only directly) in the fact that the only two scientific sources that have been presented that support your stance are the wakefield one and the recent cdc controversy.
Since riley and you decided that I was attempting to derail the conversation... I do not thing it behooves you to discuss anything that is not directly on the topic in this thread. And this, is not part of the topic.
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08 Sep 2014, 11:12 am
Feralucce wrote:
...I provided you with 107 studies, I have found 1200+ online. None of them state that there is a causative link between vaccines and autism....
At the risk of provoking more wall paper, I choose instead to link http://www.collective-evolution.com/201 ... use-autism to an otherwise enjoyable little survey of 22 studies which show possible connections to vaccines and autism. I also relink http://www.fda.gov/downloads/biologicsb ... 101580.pdf to the DtaP vaccine that was determined to result in post-approval autism adverse reactions.
_________________
Diagnosed in 2015 with ASD Level 1 by the University of Utah Health Care Autism Spectrum Disorder Clinic using the ADOS-2 Module 4 assessment instrument [11/30] -- Screened in 2014 with ASD by using the University of Cambridge Autism Research Centre AQ (Adult) [43/50]; EQ-60 for adults [11/80]; FQ [43/135]; SQ (Adult) [130/150] self-reported screening inventories -- Assessed since 1978 with an estimated IQ [≈145] by several clinicians -- Contact on WrongPlanet.net by private message (PM)
08 Sep 2014, 11:14 am
AspieUtah wrote:
At the risk of provoking more wall paper, I choose instead to link
I will look at your information in a moment, but I have requested (this makes twice) that we stop with the personal slights and attacks. This statement was inherently snide and disrespectful and I request that this conversation continue with a respectful tone.
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08 Sep 2014, 11:42 am
Study one: Unfortunately, the full text is not available. As previously stated in this conversation, an abstract does not give the full story. However, the statements from excerpts point to ethylmercury - thimerserol... which has been absent from vaccines since 1999. However, the statement prior to 1999 in a study that covers a 5 year period of vaccination records is a red flag... Warrants more in depth study...
Study two: In the conclusion of the study, they state they found a link, but cannot make conclusive statements as it is an ecologocial study and more.
"Clearly, we cannot draw definite conclusions regarding the link between Al adjuvants and autism based on an ecological study such as the present one and hence the validity of our results remains to be confirmed. A case control study with detailed examination of vaccination records and Al body burden measurements (i.e.m hair, urin, blood) in autistic and a control group of children would be one step towards this goal."
They go on to state that vaccine safety is not firmly established as often believed.
In this one conclusion excerpt these scientists state exactly what I have been trying to express. Ecological studies are not definitive... And a case control study is needed.
Study three: is also an ecological study. The issue with these studies is that they are looking at vaccination records and then seeing if the same child is diagnosed with autism... In locations with a lower income, often there are less vaccinations required (i.e. third world countries)... And at the same time, there is much less in the way of mental health care, therefore, there will be a LOT of Autistic children who do not get a diagnosis.
Study 4: thimerosal... no longer present in vaccines.
Study 5: States a theory that Autism may be caused by an atypical measles infection... And states outright that they do not know if it is the vaccine or the Mv virus.
Study 6: Makes the same statements, that their theory is a virus and the measles virus and/or the MMR vaccine may be at fault.
I could go on... but all of these have been ecological studies... All of these are indications that it warrants more study... but at this point in time, there has been nothing in the way of quantitative case studies...
I have already posited a possible experimental method... The study needs to be large... a sample size of 150 is not nearly enough... Starts prenatal, and follows a sample of 1500+ (750 vaccinated, 750 unvaccinated) across the coountry, crossing social, racial and economic borders. And a single team of psychiatric professionals using the same diagnostic criteria (including the current neurological scanning techniques) undertake the diagnostics of this entire group.
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08 Sep 2014, 11:43 am
BENSWANN.COM: "Update: Congressman?s Office In Possession of 100,000 CDC Whistleblower Documents?" (September 8, 2014)
http://www.benswann.com/update-congress ... -documents
Quote:
Congressman Bill Posey?s office has confirmed exclusively to Benswann.com that a ?very large number? of documents have been turned over by CDC scientist, Dr. William Thompson, who has admitted that the CDC suppressed information about the links between the MMR vaccine and autism in some cases.
According to Congressman Posey?s spokesman, George Cecala, ?I can confirm that we have received a very large number of documents and we are going through those documents now. There are a lot of them, so it will take some time.? Cecala could not say exactly how many documents are in possession of the Congressman?s staff though sources tell me that as many as 100,000 documents have been handed over....
According to Congressman Posey?s spokesman, George Cecala, ?I can confirm that we have received a very large number of documents and we are going through those documents now. There are a lot of them, so it will take some time.? Cecala could not say exactly how many documents are in possession of the Congressman?s staff though sources tell me that as many as 100,000 documents have been handed over....
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Diagnosed in 2015 with ASD Level 1 by the University of Utah Health Care Autism Spectrum Disorder Clinic using the ADOS-2 Module 4 assessment instrument [11/30] -- Screened in 2014 with ASD by using the University of Cambridge Autism Research Centre AQ (Adult) [43/50]; EQ-60 for adults [11/80]; FQ [43/135]; SQ (Adult) [130/150] self-reported screening inventories -- Assessed since 1978 with an estimated IQ [≈145] by several clinicians -- Contact on WrongPlanet.net by private message (PM)
08 Sep 2014, 11:49 am
Feralucce wrote:
...However, the statements from excerpts point to ethylmercury - thimerserol... which has been absent from vaccines since 1999. [...] thimerosal... no longer present in vaccines.
The CDC http://www.cdc.gov/vaccinesafety/concer ... aqs.html#f stated on Aug. 20, 2014, that "thimerosal is used as a preservative in multi-dose vials of flu vaccines, about a third of flu vaccine doses that are available."
Quote:
...I have already posited a possible experimental method... The study needs to be large... a sample size of 150 is not nearly enough... Starts prenatal, and follows a sample of 1500+ (750 vaccinated, 750 unvaccinated) across the coountry, crossing social, racial and economic borders. And a single team of psychiatric professionals using the same diagnostic criteria (including the current neurological scanning techniques) undertake the diagnostics of this entire group.
Indeed.
_________________
Diagnosed in 2015 with ASD Level 1 by the University of Utah Health Care Autism Spectrum Disorder Clinic using the ADOS-2 Module 4 assessment instrument [11/30] -- Screened in 2014 with ASD by using the University of Cambridge Autism Research Centre AQ (Adult) [43/50]; EQ-60 for adults [11/80]; FQ [43/135]; SQ (Adult) [130/150] self-reported screening inventories -- Assessed since 1978 with an estimated IQ [≈145] by several clinicians -- Contact on WrongPlanet.net by private message (PM)
08 Sep 2014, 11:58 am
AspieUtah wrote:
The CDC http://www.cdc.gov/vaccinesafety/concer ... aqs.html#f stated on Aug. 20, 2014, that "thimerosal is used as a preservative in multi-dose vials of flu vaccines, about a third of flu vaccine doses that are available."
This was a statement o which I was unaware... however, i have seen no studies that state the Flu vaccine causes it.
The Measles, mumps and rubella, vaccines are all attenuated strain vaccines... since we have ecological studies that suggest a viral link...
Still need a case control study.
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08 Sep 2014, 12:14 pm
Feralucce wrote:
...The Measles, mumps and rubella, vaccines are all attenuated strain vaccines... since we have ecological studies that suggest a viral link....
As is the Live Attenuated Influenza Vaccine [LAIV] (The Nasal Spray Flu Vaccine) http://www.cdc.gov/flu/about/qa/nasalspray.htm that the CDC states "should not be given to women who are pregnant."
_________________
Diagnosed in 2015 with ASD Level 1 by the University of Utah Health Care Autism Spectrum Disorder Clinic using the ADOS-2 Module 4 assessment instrument [11/30] -- Screened in 2014 with ASD by using the University of Cambridge Autism Research Centre AQ (Adult) [43/50]; EQ-60 for adults [11/80]; FQ [43/135]; SQ (Adult) [130/150] self-reported screening inventories -- Assessed since 1978 with an estimated IQ [≈145] by several clinicians -- Contact on WrongPlanet.net by private message (PM)
08 Sep 2014, 12:19 pm
AspieUtah wrote:
Feralucce wrote:
...The Measles, mumps and rubella, vaccines are all attenuated strain vaccines... since we have ecological studies that suggest a viral link....
As is the Live Attenuated Influenza Vaccine [LAIV] (The Nasal Spray Flu Vaccine) http://www.cdc.gov/flu/about/qa/nasalspray.htm that the CDC states "should not be given to women who are pregnant."
Again... No study has stated the flu causes autism or found a link between the flue vaccine and autism... so I am not sure what this has to do with the topic
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08 Sep 2014, 1:23 pm
Feralucce wrote:
riley wrote:
I suspect it is an attempt to derail the topic. Why? There is a subset of autism culture that view autism as nothing less than an "evolutionary mutation" making them superior. The idea that some autism is caused from brain damage threatens this cult like belief system.. and those most severely effected by autism; the ones who are adults who cannot talk and are so disabled that they still wear nappies kind of disproves the autism=superior belief.
So again. The topic is CDC coverup. It would be nice instead of blatantly trying to derail it for their own ego's sake.
So again. The topic is CDC coverup. It would be nice instead of blatantly trying to derail it for their own ego's sake.
I am going to address the extraordinary mutation comment.
You are not familiar with my blog... Ou are also not familiar with my stance or opinion on this. I have received hate mail and even a death threat for my stance that autism is a disease.
I have no interest whatsoever in reading your blog.
Quote:
Please refrain from commentary such as this as this is what I was referring to ad hominem attacks. I have addressed you personally on it, but I do not appreciate the personal attacks.
You had no problems with attacking my intelligence earlier then having a tantrum and demanding I not reply to you so I decided to stop replying to you. Much the way I do when a child is stamping their feet. If you expect people to not personally attack you perhaps you should consider not doing it yourself.
Quote:
As for the topic, you cite the story and statements which run counter to repeated studies on the subject. At this point, my stance is and always has been,that anecdotes are not evidence. Without a study to back it up, the data collected in Atlanta is an anomaly.
You cannot dismiss it as an anomaly when it was a major study.
Quote:
Without further evidence, it remains that. I refer you again, to the challenge. I always bow to truth and fact. If you can find these things in support of your stance, please do.
My point on the Italian court ruling is that eyewitness accounts have convicted many people that were then exonerated by DNA evidence. Eyewitnesses are often wrong. And courts have little grasp of science. Therefor a court opinion has no impact on scientific fact. The Galileo court case is a prime example.
My point on the Italian court ruling is that eyewitness accounts have convicted many people that were then exonerated by DNA evidence. Eyewitnesses are often wrong. And courts have little grasp of science. Therefor a court opinion has no impact on scientific fact. The Galileo court case is a prime example.
So now you have decided even court rooms cannot determine the truth if it doesn't mesh with your own beliefs. No. A courtroom would require expert testimonies.
Quote:
Accept the challenge or not, I provided you with 107 studies, I have found 1200+ online. None of them state that there is a causative link between vaccines and autism... Find us some. Because if your stance is correct, I want vaccines outlawed.
I don't want to make vaccines outlawed I want them to be made safer for those prone to injury from them.
Quote:
http://www.ncbi.nlm.nih.gov/pubmed/21058170
Hepatitis B vaccination of male neonates and autism diagnosis, NHIS 1997-2002.
Gallagher CM1, Goodman MS.
Author information
Abstract
Universal hepatitis B vaccination was recommended for U.S. newborns in 1991; however, safety findings are mixed. The association between hepatitis B vaccination of male neonates and parental report of autism diagnosis was determined. This cross-sectional study used weighted probability samples obtained from National Health Interview Survey 1997-2002 data sets. Vaccination status was determined from the vaccination record. Logistic regression was used to estimate the odds for autism diagnosis associated with neonatal hepatitis B vaccination among boys age 3-17 years, born before 1999, adjusted for race, maternal education, and two-parent household. Boys vaccinated as neonates had threefold greater odds for autism diagnosis compared to boys never vaccinated or vaccinated after the first month of life. Non-Hispanic white boys were 64% less likely to have autism diagnosis relative to nonwhite boys. Findings suggest that U.S. male neonates vaccinated with the hepatitis B vaccine prior to 1999 (from vaccination record) had a threefold higher risk for parental report of autism diagnosis compared to boys not vaccinated as neonates during that same time period. Nonwhite boys bore a greater risk.
Hepatitis B vaccination of male neonates and autism diagnosis, NHIS 1997-2002.
Gallagher CM1, Goodman MS.
Author information
Abstract
Universal hepatitis B vaccination was recommended for U.S. newborns in 1991; however, safety findings are mixed. The association between hepatitis B vaccination of male neonates and parental report of autism diagnosis was determined. This cross-sectional study used weighted probability samples obtained from National Health Interview Survey 1997-2002 data sets. Vaccination status was determined from the vaccination record. Logistic regression was used to estimate the odds for autism diagnosis associated with neonatal hepatitis B vaccination among boys age 3-17 years, born before 1999, adjusted for race, maternal education, and two-parent household. Boys vaccinated as neonates had threefold greater odds for autism diagnosis compared to boys never vaccinated or vaccinated after the first month of life. Non-Hispanic white boys were 64% less likely to have autism diagnosis relative to nonwhite boys. Findings suggest that U.S. male neonates vaccinated with the hepatitis B vaccine prior to 1999 (from vaccination record) had a threefold higher risk for parental report of autism diagnosis compared to boys not vaccinated as neonates during that same time period. Nonwhite boys bore a greater risk.
Actually I think I already posted this one earlier but that wasn't good enough.
Quote:
http://www.ncbi.nlm.nih.gov/pubmed/21623535
A positive association found between autism prevalence and childhood vaccination uptake across the U.S. population.
Delong G.
Author information
Abstract
The reason for the rapid rise of autism in the United States that began in the 1990s is a mystery. Although individuals probably have a genetic predisposition to develop autism, researchers suspect that one or more environmental triggers are also needed. One of those triggers might be the battery of vaccinations that young children receive. Using regression analysis and controlling for family income and ethnicity, the relationship between the proportion of children who received the recommended vaccines by age 2 years and the prevalence of autism (AUT) or speech or language impairment (SLI) in each U.S. state from 2001 and 2007 was determined. A positive and statistically significant relationship was found: The higher the proportion of children receiving recommended vaccinations, the higher was the prevalence of AUT or SLI. A 1% increase in vaccination was associated with an additional 680 children having AUT or SLI. Neither parental behavior nor access to care affected the results, since vaccination proportions were not significantly related (statistically) to any other disability or to the number of pediatricians in a U.S. state. The results suggest that although mercury has been removed from many vaccines, other culprits may link vaccines to autism. Further study into the relationship between vaccines and autism is warranted.
A positive association found between autism prevalence and childhood vaccination uptake across the U.S. population.
Delong G.
Author information
Abstract
The reason for the rapid rise of autism in the United States that began in the 1990s is a mystery. Although individuals probably have a genetic predisposition to develop autism, researchers suspect that one or more environmental triggers are also needed. One of those triggers might be the battery of vaccinations that young children receive. Using regression analysis and controlling for family income and ethnicity, the relationship between the proportion of children who received the recommended vaccines by age 2 years and the prevalence of autism (AUT) or speech or language impairment (SLI) in each U.S. state from 2001 and 2007 was determined. A positive and statistically significant relationship was found: The higher the proportion of children receiving recommended vaccinations, the higher was the prevalence of AUT or SLI. A 1% increase in vaccination was associated with an additional 680 children having AUT or SLI. Neither parental behavior nor access to care affected the results, since vaccination proportions were not significantly related (statistically) to any other disability or to the number of pediatricians in a U.S. state. The results suggest that although mercury has been removed from many vaccines, other culprits may link vaccines to autism. Further study into the relationship between vaccines and autism is warranted.
Quote:
http://www.hindawi.com/journals/jt/2013/801517/
Journal of Toxicology
Volume 2013 (2013), Article ID 801517, 11 pages
http://dx.doi.org/10.1155/2013/801517
Research Article
B-Lymphocytes from a Population of Children with Autism Spectrum Disorder and Their Unaffected Siblings Exhibit Hypersensitivity to Thimerosal
Martyn A. Sharpe, Taylor L. Gist, and David S. Baskin
Department of Neurosurgery, The Methodist Neurological Institute, 6560 Fannin Street, Scurlock Tower No. 944, Houston, TX 77030, USA
Received 29 March 2013; Accepted 17 May 2013
Academic Editor: Lucio Guido Costa
Copyright © 2013 Martyn A. Sharpe et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
The role of thimerosal containing vaccines in the development of autism spectrum disorder (ASD) has been an area of intense debate, as has the presence of mercury dental amalgams and fish ingestion by pregnant mothers. We studied the effects of thimerosal on cell proliferation and mitochondrial function from B-lymphocytes taken from individuals with autism, their nonautistic twins, and their nontwin siblings. Eleven families were examined and compared to matched controls. B-cells were grown with increasing levels of thimerosal, and various assays (LDH, XTT, DCFH, etc.) were performed to examine the effects on cellular proliferation and mitochondrial function. A subpopulation of eight individuals (4 ASD, 2 twins, and 2 siblings) from four of the families showed thimerosal hypersensitivity, whereas none of the control individuals displayed this response. The thimerosal concentration required to inhibit cell proliferation in these individuals was only 40% of controls. Cells hypersensitive to thimerosal also had higher levels of oxidative stress markers, protein carbonyls, and oxidant generation. This suggests certain individuals with a mild mitochondrial defect may be highly susceptible to mitochondrial specific toxins like the vaccine preservative thimerosal.
Journal of Toxicology
Volume 2013 (2013), Article ID 801517, 11 pages
http://dx.doi.org/10.1155/2013/801517
Research Article
B-Lymphocytes from a Population of Children with Autism Spectrum Disorder and Their Unaffected Siblings Exhibit Hypersensitivity to Thimerosal
Martyn A. Sharpe, Taylor L. Gist, and David S. Baskin
Department of Neurosurgery, The Methodist Neurological Institute, 6560 Fannin Street, Scurlock Tower No. 944, Houston, TX 77030, USA
Received 29 March 2013; Accepted 17 May 2013
Academic Editor: Lucio Guido Costa
Copyright © 2013 Martyn A. Sharpe et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
The role of thimerosal containing vaccines in the development of autism spectrum disorder (ASD) has been an area of intense debate, as has the presence of mercury dental amalgams and fish ingestion by pregnant mothers. We studied the effects of thimerosal on cell proliferation and mitochondrial function from B-lymphocytes taken from individuals with autism, their nonautistic twins, and their nontwin siblings. Eleven families were examined and compared to matched controls. B-cells were grown with increasing levels of thimerosal, and various assays (LDH, XTT, DCFH, etc.) were performed to examine the effects on cellular proliferation and mitochondrial function. A subpopulation of eight individuals (4 ASD, 2 twins, and 2 siblings) from four of the families showed thimerosal hypersensitivity, whereas none of the control individuals displayed this response. The thimerosal concentration required to inhibit cell proliferation in these individuals was only 40% of controls. Cells hypersensitive to thimerosal also had higher levels of oxidative stress markers, protein carbonyls, and oxidant generation. This suggests certain individuals with a mild mitochondrial defect may be highly susceptible to mitochondrial specific toxins like the vaccine preservative thimerosal.
Quote:
http://ajcn.nutrition.org/content/80/6/1611.full
Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism1,2
S Jill James,
Paul Cutler,
Stepan Melnyk,
Stefanie Jernigan,
Laurette Janak,
David W Gaylor, and
James A Neubrander
+ Author Affiliations
1From the Department of Pediatrics, University of Arkansas for Medical Sciences, and the Arkansas Children's Hospital Research Institute, Little Rock, AR (SJJ, SM, and SJ); Niagara Falls, NY (PC); Colden, NY (LJ); Gaylor and Associates, LLC, Eureka Springs, AR (DWG); and Edison, NJ (JAN)
Next Section
Abstract
Background: Autism is a complex neurodevelopmental disorder that usually presents in early childhood and that is thought to be influenced by genetic and environmental factors. Although abnormal metabolism of methionine and homocysteine has been associated with other neurologic diseases, these pathways have not been evaluated in persons with autism.
Objective: The purpose of this study was to evaluate plasma concentrations of metabolites in the methionine transmethylation and transsulfuration pathways in children diagnosed with autism.
Design: Plasma concentrations of methionine, S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH), adenosine, homocysteine, cystathionine, cysteine, and oxidized and reduced glutathione were measured in 20 children with autism and in 33 control children. On the basis of the abnormal metabolic profile, a targeted nutritional intervention trial with folinic acid, betaine, and methylcobalamin was initiated in a subset of the autistic children.
Results: Relative to the control children, the children with autism had significantly lower baseline plasma concentrations of methionine, SAM, homocysteine, cystathionine, cysteine, and total glutathione and significantly higher concentrations of SAH, adenosine, and oxidized glutathione. This metabolic profile is consistent with impaired capacity for methylation (significantly lower ratio of SAM to SAH) and increased oxidative stress (significantly lower redox ratio of reduced glutathione to oxidized glutathione) in children with autism. The intervention trial was effective in normalizing the metabolic imbalance in the autistic children.
Conclusions: An increased vulnerability to oxidative stress and a decreased capacity for methylation may contribute to the development and clinical manifestation of autism.
Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism1,2
S Jill James,
Paul Cutler,
Stepan Melnyk,
Stefanie Jernigan,
Laurette Janak,
David W Gaylor, and
James A Neubrander
+ Author Affiliations
1From the Department of Pediatrics, University of Arkansas for Medical Sciences, and the Arkansas Children's Hospital Research Institute, Little Rock, AR (SJJ, SM, and SJ); Niagara Falls, NY (PC); Colden, NY (LJ); Gaylor and Associates, LLC, Eureka Springs, AR (DWG); and Edison, NJ (JAN)
Next Section
Abstract
Background: Autism is a complex neurodevelopmental disorder that usually presents in early childhood and that is thought to be influenced by genetic and environmental factors. Although abnormal metabolism of methionine and homocysteine has been associated with other neurologic diseases, these pathways have not been evaluated in persons with autism.
Objective: The purpose of this study was to evaluate plasma concentrations of metabolites in the methionine transmethylation and transsulfuration pathways in children diagnosed with autism.
Design: Plasma concentrations of methionine, S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH), adenosine, homocysteine, cystathionine, cysteine, and oxidized and reduced glutathione were measured in 20 children with autism and in 33 control children. On the basis of the abnormal metabolic profile, a targeted nutritional intervention trial with folinic acid, betaine, and methylcobalamin was initiated in a subset of the autistic children.
Results: Relative to the control children, the children with autism had significantly lower baseline plasma concentrations of methionine, SAM, homocysteine, cystathionine, cysteine, and total glutathione and significantly higher concentrations of SAH, adenosine, and oxidized glutathione. This metabolic profile is consistent with impaired capacity for methylation (significantly lower ratio of SAM to SAH) and increased oxidative stress (significantly lower redox ratio of reduced glutathione to oxidized glutathione) in children with autism. The intervention trial was effective in normalizing the metabolic imbalance in the autistic children.
Conclusions: An increased vulnerability to oxidative stress and a decreased capacity for methylation may contribute to the development and clinical manifestation of autism.
I have others I could post but thus far you have dismissed anything that does not conform to your views so I really do not see any point. I suspect you will dismiss these as well. I mean you have already decided that the court system is BS.. which means there'd be no point me posting PROVEN cases like Hannah Poling as you've already decided they're crap.
Oh and AGAIN. This topic is about the CDC covering up vaccine autism statistics.. it's been proven now.
08 Sep 2014, 3:56 pm
riley wrote:
You had no problems with attacking my intelligence earlier then having a tantrum and demanding I not reply to you so I decided to stop replying to you. Much the way I do when a child is stamping their feet. If you expect people to not personally attack you perhaps you should consider not doing it yourself.
Riley:
You started with the snide commentary and rude interjections... And i reacted badly... I have admitted as much. Again, you cannot shame me with my words when I have owned up.
That being said... I am moving forward... If you cannot move on from that, then that is on you... but I have made my request, I have admitted my wrong... This is the second request to move past it.
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You cannot dismiss it as an anomaly when it was a major study.
Yes... you can... ONE study is the anomaly... it doesn't matter the scope or scale ... it is A study. For it to have validity, it has to be repeatable.
Each study, scientifically speaking has an absolute value of 1. Each study that provided corroborating results adds 1 to it's total of scientific weight. One study that counters it is a -1. Assuming the 27 studies cited in AspieUtah's post are all valid, that is 29 studies in the negative versus 1200+ in the positive.
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I don't want to make vaccines outlawed I want them to be made safer for those prone to injury from them.
It was an if, then statement. At this point, I don't want that either.
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I have others I could post but thus far you have dismissed anything that does not conform to your views so I really do not see any point. I suspect you will dismiss these as well. I mean you have already decided that the court system is BS.. which means there'd be no point me posting PROVEN cases like Hannah Poling as you've already decided they're crap.
I actually addressed that very study a few posts ago...
And I have stated that all of these are ecological studies.
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All of these are indications that it warrants more study... but at this point in time, there has been nothing in the way of quantitative case studies...
I have already posited a possible experimental method... The study needs to be large... a sample size of 150 is not nearly enough... Starts prenatal, and follows a sample of 1500+ (750 vaccinated, 750 unvaccinated) across the coountry, crossing social, racial and economic borders. And a single team of psychiatric professionals using the same diagnostic criteria (including the current neurological scanning techniques) undertake the diagnostics of this entire group.
I have already posited a possible experimental method... The study needs to be large... a sample size of 150 is not nearly enough... Starts prenatal, and follows a sample of 1500+ (750 vaccinated, 750 unvaccinated) across the coountry, crossing social, racial and economic borders. And a single team of psychiatric professionals using the same diagnostic criteria (including the current neurological scanning techniques) undertake the diagnostics of this entire group.
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Oh and AGAIN. This topic is about the CDC covering up vaccine autism statistics.. it's been proven now.
Okay... So... there ya go... that conversation is over...
Now... my points with the court cases is that those people that were convicted by eyewitness testimony were wrongly convicted. The eyewitnesses were wrong. period. DNA evidence exonerated the suspect. Scientific evidence proved the eyewitness accounts to be wrong.
Eyewitness accounts - anecdotal evidence is what leads us to conduct scientific studies. It does not, however, factor into the methods. It doesn't qualify as actual data.
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Yeah. I'm done. Don't bother messaging and expecting a response - i've left WP permanently.
