Emergence of a Deadly Coronavirus

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I wonder whether the rules are being enforced more strictly there than here. It seems likely.

I remember in Rocky when he fought the Russian I wanted the Russian to win because he seemed to deserve it being so disciplined and proper. Also I like the hair of his mentor or coach or wife--whatever she was.

I know it's not necessarily accurate because of all the videos of Russian dashcams showing them do wild things (rule breaking) which is why I think maybe they use police and force you to isolate and distance.

Trudeau was being too mild-mannered so nobody listened and there were clips on the news of people completely carrying on like usual in public places - crowds.

I think it proves that gentleness is a bad quality in some matters. Because people only listen to roughness.

This man is basically saying the same thing as EzraS. It's worth reading because he goes into a lot of detail about related issues

https://news.yahoo.com/why-nobel-laurea ... 18391.html

White House public health expert says anyone who recently left New York should self-quarantine

The good, the bad, and the ugly.

The Good:
It is good Kristina Keneally is hammering those who allowed The "Ruby Princess" cruise ship to enter NSW without proper/critical health considerations. Keep at it!! !

The Bad:
Instead of her getting stuck into who was actually responsible, the *NSW* *state* health minister, she is engaging in partisan party politics by attacking Scott Morrison instead.

The Ugly:
Not Kristina.
She is gorgeous. <sigh>

I went down another rabbit hole.

I thought that if it turns out that chloroquine is effective at treating COVID19 perhaps it might treat other coronaviruses. We have had two others coronavirus epidemics, SARS and MERS. The SARS epidemic lasted 6 months and is over. But the MERS coronavirus still periodically appears. So I thought I might search to see if chloroquine was ever tested against MERS as a treatment. That led to a 2014 study that was at the cell level which identified four existing compounds that were effective against MERS coronavirus and one of these was chloroquine.

The abstract of the paper reads:
Coronaviruses can cause respiratory and enteric disease in a wide variety of human and animal hosts. The 2003 outbreak of severe acute respiratory syndrome (SARS) first demonstrated the potentially lethal consequences of zoonotic coronavirus infections in humans. In 2012, a similar previously unknown coronavirus emerged, Middle East respiratory syndrome coronavirus (MERS-CoV), thus far causing over 650 laboratory-confirmed infections, with an unexplained steep rise in the number of cases being recorded over recent months. The human MERS fatality rate of ∼ 30% is alarmingly high, even though many deaths were associated with underlying medical conditions. Registered therapeutics for the treatment of coronavirus infections are not available. Moreover, the pace of drug development and registration for human use is generally incompatible with strategies to combat emerging infectious diseases. Therefore, we have screened a library of 348 FDA-approved drugs for anti-MERS-CoV activity in cell culture. If such compounds proved sufficiently potent, their efficacy might be directly assessed in MERS patients. We identified four compounds (chloroquine, chlorpromazine, loperamide, and lopinavir) inhibiting MERS-CoV replication in the low-micromolar range (50% effective concentrations [EC(50)s], 3 to 8 μM). Moreover, these compounds also inhibit the replication of SARS coronavirus and human coronavirus 229E. Although their protective activity (alone or in combination) remains to be assessed in animal models, our findings may offer a starting point for treatment of patients infected with zoonotic coronaviruses like MERS-CoV. Although they may not necessarily reduce viral replication to very low levels, a moderate viral load reduction may create a window during which to mount a protective immune response.

Source: Screening of an FDA-approved compound library identifies four small-molecule inhibitors of Middle East respiratory syndrome coronavirus replication in cell culture. Antimicrob Agents Chemother. 2014 Aug;58(8):4875-84. doi: 10.1128/AAC.03011-14. Epub 2014 May 19.