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Antibodies from mothers of autistics cause autism in monkeys

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zendell
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01 Mar 2008, 7:27 pm

Sora wrote:
zendell, being the pendant I am, I think your topic line should read 'Antibodies from mothers of autistics cause symptoms of autism in monkeys'. Not whatever it reads right now.


The reason I didn't write that is because I didn't have enough room. It wouldn't let me make the topic line any longer.

Sora wrote:
Symptoms of autism occur in many many neurological disorders. Even down's syndrome. Severe brain injuries too. Symptoms of autism are not exclusive to autism only.

Interesting article otherwise, as almost always.


I know that. I've actually been interested in it because the prevalence of many neurological disorders such as multiple sclerosis and chronic fatigue syndrome has been increasing along with autism. Autism, MS and CFS have overlapping symptoms and research has found similar abnormalities in people with autism, MS, and CFS.

I'm glad you liked the article.



Apatura
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01 Mar 2008, 8:11 pm

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research I've read on autoimmune disorders, a combination of genetics and environmental factors (such as mercury and chronic infections) are involved. The reason a mother can have 5 kids with only 1 or 2 autistic is due to genetic differences. If mercury is involved, the effects could be very different for each person (from no noticeable symptoms to severe neurological problems) due to genetics.


But all the monkeys in this study displayed autistic traits, yet each monkey (I assume) was genetically distinct, unless they were testing on clones. As far as environmental factors-- I assume each monkey was given the same foods, medicines, etc.-- there were no deliberately varied environmental elements. Did some monkeys get infections while others didn't?

It's hard to believe that immunoglobins and environment are the causes because fraternal twins have such a low rate of autistic congruency compared to identical twins (10% vs 90% I believe). Same womb, same vaccines.



MusicMaker1
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01 Mar 2008, 8:32 pm

What I find surprising is that in identical twins, the rate isn't 100% ... I remember being surprised the first time I read that NOT all identical twins share having autistic features.. Does this mean that one of the identical twins can end up being perfectly normal, while the other identical sibling shows full blown autism? If this really is the case, then clearly there's something more than just genetics.. Possiby it is some toxin.. What if the child was abused in some way? Sometimes trauma can cause a person to "retreat within themselves"... I've heard where child abuse can actually slow the development of the brain in certain areas... Or what if it was a head injury? Whatever it is, it's not purely genetic if both identical twins don't share the same "disorder"... If it has something to do with antibodies that their mother has, then they would BOTH have it, right? Same womb, same antibodies, same genetics even....

It MUSt be some outside factor...toxins, abuse, trauma? If it were toxins, it also seems that both children would be exposed to the same environment, foods, etc.. How do they go about finding this out?? I'm surprised with all the publicity that autism is still the huge mystery that it is...



Last edited by MusicMaker1 on 02 Mar 2008, 12:10 am, edited 3 times in total.

zendell
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02 Mar 2008, 12:02 am

MusicMaker1 wrote:
What I find surprising is that in identical twins, the rate isn't 100% ... I remember being surprised the first time I read that NOT all identical twins share having autistic features.. Does this mean that one of the identical twins can end up being perfectly normal, while the other identical sibling shows full blown autism? If this really is the case, then clearly there's something more than just genetics.. Possiby it is some toxin.. What if the child was abused in some way? I've heard where child abuse can actually slow the development of the brain... Or what if it was a head injury? Whatever it is, it's not purely genetic if both identical twins don't share the same "disorder"... If it has something to do with antibodies that their mother has, then they would BOTH have it, right? Same womb, same antibodies, same genetics even....

It MUSt be some outside factor... toxins is my guess... but how does one go about proving that? I'm surprised with all the publicity that autism is still the huge mystery that it is...


"Does this mean that one of the identical twins can end up being perfectly normal, while the other identical sibling shows full blown autism?" I think so. The genetic studies are what convinces me that there are non-genetic factors. Many people state the rate of ASDs in identical twins when one has an ASD is 90% and assume at least 90% of autism is genetic. The actual rate varied in each study between 60-90%. When they looked at just autistic disorder (without including AS and PDD-NOS), it was only 36-50%.

So if you have identical twins where one is diagnosed with autistic disorder (classic autism), the other identical twin will be:

autistic "disorder" - 42% of the time
AS or PDD-NOS - 33% of the time
neurotypical - 25% of the time



Apatura
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02 Mar 2008, 9:34 am

MusicMaker1 wrote:
What I find surprising is that in identical twins, the rate isn't 100% ... I remember being surprised the first time I read that NOT all identical twins share having autistic features.. Does this mean that one of the identical twins can end up being perfectly normal, while the other identical sibling shows full blown autism?


Someone here stated that there is a random Y expression in females that can account for the 10% autistic incongruency in identical twins.