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blooiejagwa
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10 Apr 2020, 9:55 pm

I swear jimmym my mom was saying the same thing about TB vaccines and all to me 2 or 3 days ago.. She said she was optimistic for us bcuz we all were born in different third world countries where we got more vaccines that targeted TB and other big things.

She has a very scientific mind and is always spot on about health-related things


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cyberdad
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10 Apr 2020, 10:03 pm

eikonabridge wrote:
See, you cannot wish for "herd immunity" (that means to let the virus propagate freely, infecting everybody, theoretically good for the economy), and at the same time wish for low number of deaths. The two wishes are just not compatible..


Yes this is a flaw with the current application of epidemiological modelling. If there is a goal to achieve herd immunity before lifting lockdown restrictions then the current lockdown and social isolation will (ironically) not achieve the aforementioned goal because infections rates are reducing so slows down herd immunity.

Haven't wrapped my head around that?



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10 Apr 2020, 11:03 pm

EzraS wrote:
So far how things have been handled and reported by agencies is becoming highly questionable based on reliable sources. Basically it comes down to making things look worse than they are. Over exaggerated model predictions, deaths being misattributed to covid19, the seriousness of cases being over exaggerated and patients being put on ventilators when it wasn't necessary. The list keeps getting bigger. Approximately 7,500 people normally die each day in America. That's up to 53,000 deaths per week. Now we know what is done with some of those thousands.

What does anyone gain by making things look worse than they are, especially in predictions?

See, when you put forth conspiracy theories, at least you need to give a motive. By making wrong predictions, anyone will look bad. What does anyone gain from making wrong predictions? In all the prediction curves, they also give out the error bars. You look at the error bars (confidence interval) and you will probably shake your head at their range: it spans nearly an order of magnitude, or at least a factor of 4. Here is one example of such a chart:

Image

Please also look at Fig. 9 in this paper: http://www.healthdata.org/sites/default/files/files/research_articles/2020/covid_paper_MEDRXIV-2020-043752v1-Murray.pdf

The paper came out March 26. The total final number of deaths was predicted to be between 38,242 to 162,106 deaths. I mean, the uncertainty was a factor of 4. That's the nature of the beast: depending on a lot of factors and a bit on luck, the final numbers in epidemiological situations vary wildly. I had friends who studied cosmology. They always joke around that in particle physics we chased after 11~12 significant digits (electron's fine structure constant, and also anomalous magnetic dipole moment), whereas in astronomy they'd be happy with getting the order of magnitude right, and whereas in cosmology they'd be happy with getting the "order of magnitude of the order of magnitude" right.

I have the doubling period for the number of cases and number of deaths in US.

date, DP #cases, DP #deaths
3/21/2020 1.9 2.7
3/22/2020 1.9 2.4
3/23/2020 2.1 2.2
3/24/2020 2.4 2.1
3/25/2020 2.6 2.5
3/26/2020 2.9 2.5
3/27/2020 3.2 2.7
3/28/2020 3.4 2.7
3/29/2020 3.4 2.8
3/30/2020 3.8 3.1
3/31/2020 4.3 3.2
4/1/2020 4.7 3.3
4/2/2020 5.0 3.2
4/3/2020 5.1 3.1
4/4/2020 5.3 3.4
4/5/2020 5.6 3.9
4/6/2020 6.2 4.3
4/7/2020 6.9 4.6
4/8/2020 7.8 4.8
4/9/2020 8.5 4.9
4/10/2020 8.6 5.0

Back in March 21, US's doubling period for number of cases was 1.9 days. That was a moment that anyone in charge would panic: you did not even have time to think. (Whereas Taiwan is currently cruising at 60 days). Projecting the future at that moment was exceeding difficult. You need to cut some slack to any estimate made at that time. It was an impossible task to get any prediction accurately, when things were still in the exponential phase. I mean, at doubling period of 2 days, if you have an error of +/- 2 days (forward or backward), your error factor would be 4.

There are excess deaths. When all is settled, people will dig into those numbers, like in Italy. No one benefits from doing wrong predictions. Trump is gambling on the amount of hydroxychloroquine needed, how come you don't say anything? See, in epidemiology, it is inherently hard to make predictions. With masks, PPEs, ventilators, beds, number of cases, number deaths, number of test kits, number of pills, you'll be lucky to get them right within a factor 2. Most of the times you'll probably err by a factor 4. If your resources are short by a factor 4, you get the situation in Italy and Wuhan, with corpses lying around hospital corridors and doctors having to decide who to let die. Not fun. In NYC we just erred luckily on the right side. Yeah, we have two fairly empty ships, one in New York City and another one in Los Angeles. But that's better than going through the same situation of Wuhan or Italy.



cyberdad
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10 Apr 2020, 11:50 pm

Before this thread moves off on another tangent...

Every country can’t stay in lockdown forever, and in order for life to return to normal, there are only two ways that the virus can be defeated.
Either a vaccine is found or the country develops “herd immunity” which means about 60 per cent of the population need to be infected.

For Australia that's 15 million people and for the US that's 197 million.....how realistic is this?



EzraS
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11 Apr 2020, 12:04 am

eikonabridge wrote:
EzraS wrote:
So far how things have been handled and reported by agencies is becoming highly questionable based on reliable sources. Basically it comes down to making things look worse than they are. Over exaggerated model predictions, deaths being misattributed to covid19, the seriousness of cases being over exaggerated and patients being put on ventilators when it wasn't necessary. The list keeps getting bigger. Approximately 7,500 people normally die each day in America. That's up to 53,000 deaths per week. Now we know what is done with some of those thousands.

What does anyone gain by making things look worse than they are, especially in predictions?

See, when you put forth conspiracy theories, at least you need to give a motive.


I am going by what credible sources have been saying; That the model forecasts have been inaccurate and that common deaths have been misattributed to covid19. If true I consider these things to be more likely a matter of screw ups rather than a conspiracy taking place, because I am a sensible person. You have been very consistent in misinterpreting me.



Last edited by EzraS on 11 Apr 2020, 12:11 am, edited 1 time in total.

eikonabridge
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11 Apr 2020, 12:11 am

Trump aides look to punish WHO
https://www.politico.com/news/2020/04/10/trump-aides-debate-demands-who-179291

Quote:
Aides to President Donald Trump are debating some potentially far-reaching moves to punish the World Health Organization in the wake of the coronavirus pandemic, including cutting off U.S. funding and trying to create an alternative institution.

Lost in Beijing: The Story of the WHO
https://www.wsj.com/articles/lost-in-beijing-the-story-of-the-who-11586365090
Quote:
China broke the World Health Organization. The U.S. has to fix it or leave and start its own group.

Let us think about it. In WHO, every single country has one vote. US contributes the most money. It gets one vote. The African countries contribute next to nothing, they get something like 53 votes. Therefore, the life and death of the people in developed countries are controlled by a whole lot of underdeveloped and corrupt countries from Africa. Does that even make sense?

Sorry, democracy at international sovereign level just plainly doesn't make any sense.

Either WHO has to be totally revamped and the governing rules be re-written, or if countries continue to play politics with people's lives, then it's better to part ways with something that cannot be fixed. I think we are back to cold-war era arrangements. It's best to have a few separate organizations, and these organizations can then share or exchange information in an as-needed basis, in consultation with each other. NEVER AGAIN would we allow underdeveloped and corrupt countries to dictate our health matters.


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EzraS
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11 Apr 2020, 12:27 am

cyberdad wrote:
Before this thread moves off on another tangent...

Every country can’t stay in lockdown forever, and in order for life to return to normal, there are only two ways that the virus can be defeated.
Either a vaccine is found or the country develops “herd immunity” which means about 60 per cent of the population need to be infected.

For Australia that's 15 million people and for the US that's 197 million.....how realistic is this?


It seems entirely possible that 60% of the population has already been infected. But that 95% of those infections have been asymptomatic or close to asymptomatic so they have gone unnoticed and unreported. Probably what needs to happen is that millions of people need to get themselves tested. Especially those who are out of work to push things forward to an end date for the lockdowns. The question is, is the system equipped to handle millions of people coming in to get tested.



Amity
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11 Apr 2020, 12:40 am

jimmy m wrote:
This is interesting!

Countries that do not have a BCG vaccination policy saw ten times greater incidence of and mortality from Covid-19, compared with those who do, a forthcoming study from medical researchers in the US and UK, which analysed data from 178 countries, has found.

BCG, or Bacillus Calmette-Guérin, is a vaccine for tuberculosis and is administered at birth in countries that have historically suffered from the disease, such as India. Many rich nations, such as the US, Italy and Holland, have never had a universal BCG vaccination policy.

The study looked at Covid-19 instances and mortality for 15 days between 9 and 24 March in 178 countries and concluded that “incidence of Covid-19 was 38.4 per million in countries with BCG vaccination compared to 358.4 per million in the absence of such a program. The death rate was 4.28/million in countries with BCG programs compared to 40/million in countries without such a program.” Out of the 178 countries studied, 21 had no vaccination program, while the status was unclear in 26 countries. The latter group was treated as not having a policy for the purpose of this study.

“While we expected to see a protective effect of BCG, the magnitude of the difference (almost 10 fold) in incidence and mortality (of Covid-19) between countries with and without a BCG vaccination program was pleasantly surprising,” said Dr Ashish Kamat, a co-author of the paper and professor of Urologic Oncology (Surgery) and cancer research at MD Anderson Cancer Center in Houston, Texas.

In recent weeks, BCG has emerged as a candidate vaccine for Covid-19, and a 4,000-person clinical trial to test its efficacy against the disease is currently underway in Australia. . But what that means for populations that were inoculated with BCG vaccine in their childhood is not yet clear as SARS-CoV-2 continues to spread around the world, having now infected more than a million people.

“There exists a plethora of evidence from well conducted studies in prestigious peer reviewed journals, as well as through randomized control trials about the effectiveness of BCG vaccine, to confer protective immunity against viral infection,” Dr Kamat said, speaking with ET on the phone from the US.

The question of whether populations that have received BCG vaccination are more resistant to Covid-19 is a critical one as countries put in place lockdowns and economies grind to a halt, hitting people at the economic margins hard, especially in countries such as India. Every day of the ongoing lockdown will cost the Indian economy $4.64 billion, Acuité Research said in a report. But having witnessed the morbid dance of the disease in countries such as Italy, where more than 13,000 people have died, governments are disinclined to take a chance.

“Countries with national program of whole-population BCG vaccination appear to have a lower incidence and death rate from Covid-19. This may be due to the known immunological benefits of BCG vaccination. In the absence of a specific vaccination against Covid-19, population-based BCG vaccination may have a role in reducing the impact of this disease,” says the paper, currently available on ResearchGate, a portal where scientists share studies, and is being reviewed for publication by multiple scientific journals. It’s co-authored by Paul Hegarty and Helen Zafirakis of the Mater Misericordiae University Hospital, Dublin, Ireland and Andrew DiNardo at the Baylor College of Medicine, Houston, Texas.

Dr Kamat says his institution is now also embarking on its own clinical trial by vaccinating healthcare workers. “We are commencing a study in the near future, initially planned for about 1,000 healthcare workers, but with plans to rapidly expand to multiple sites as the demand increases. We will vaccinate healthcare workers at highest risk first, such as those who work in emergency centers, ICUs and watch for how protective the vaccine proves. Clearly the data will be monitored and will be done under the auspices of regulatory bodies including the FDA.” He added that talks are on with institutions in India to take part in the study.

BCG vaccine is used in early stage immunotherapy in bladder cancer and Dr Kamat is a top authority in that field. He is also the president of the International Bladder Cancer Group.

The study says while there might be confounding factors in the correlation, the trend is striking. “We recognize that these data are observational and based on a single time-point and that there may be several confounding issues such as limited testing and reporting in many countries. However as these data are derived from 178 countries, the trend is striking and supports the mechanistic data that exists for BCG as a protective agent not only for viral and other infections but also against cancer.”

But childhood inoculation doesn’t necessarily mean life-long immunity. “But a PPD (purified protein derivative) test can indicate whether or not a person still has BCG-induced immunity or needs to be revaccinated. This could be used to selectively revaccinate high-risk groups or to decide who among the population might be safer against SARS-CoV-2 and could potentially go back into the workforce, for instance,” Dr Kamat said, adding that any policy decision relating to Covid-19 should wait for what the clinical trials say.

Earlier this week, a study from the New York Institute of Technology also noted that countries with a universal vaccination policy, such as Japan and Brazil, seemed to be impacted less by Covid-19 compared with those that did not, such as Italy, US and The Netherlands.

The results from clinical trials involving BCG vaccination for Covid-19 will be closely watched. “Indians have always been at the forefront of advances in medicine; here it is ironic that one of our oldest immunotherapies (BCG, used in India for decades) might help against the newest threat facing our civilization,” Dr Kamat said.

Source: BCG vaccination policies make a ten times difference in Covid-19 incidence, mortality: New study

The UK stopped administering BCG in 2005 and in Ireland we stopped in 2015 due to supply issues, I read about this a few days ago and wondered if the higher numbers of younger children affected by C19 is related to the lack of the BCG inoculation in recent years.
It does seem promising
Irish Times

Quote:
US virologist Robert Gallo of the Institute of Human Virology in Maryland has confirmed he is working with a team who will make an announcement shortly that will have “a major effect” on global efforts to tackle Covid-19.



cyberdad
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11 Apr 2020, 1:49 am

EzraS wrote:
cyberdad wrote:
Before this thread moves off on another tangent...

Every country can’t stay in lockdown forever, and in order for life to return to normal, there are only two ways that the virus can be defeated.
Either a vaccine is found or the country develops “herd immunity” which means about 60 per cent of the population need to be infected.

For Australia that's 15 million people and for the US that's 197 million.....how realistic is this?


It seems entirely possible that 60% of the population has already been infected. But that 95% of those infections have been asymptomatic or close to asymptomatic so they have gone unnoticed and unreported. Probably what needs to happen is that millions of people need to get themselves tested. Especially those who are out of work to push things forward to an end date for the lockdowns. The question is, is the system equipped to handle millions of people coming in to get tested.


Yes agree that testing is necessary but reliable test-kits are hard to come by...(not the made in China ones)



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11 Apr 2020, 2:27 am

cyberdad wrote:
EzraS wrote:
cyberdad wrote:
Before this thread moves off on another tangent...

Every country can’t stay in lockdown forever, and in order for life to return to normal, there are only two ways that the virus can be defeated.
Either a vaccine is found or the country develops “herd immunity” which means about 60 per cent of the population need to be infected.

For Australia that's 15 million people and for the US that's 197 million.....how realistic is this?


It seems entirely possible that 60% of the population has already been infected. But that 95% of those infections have been asymptomatic or close to asymptomatic so they have gone unnoticed and unreported. Probably what needs to happen is that millions of people need to get themselves tested. Especially those who are out of work to push things forward to an end date for the lockdowns. The question is, is the system equipped to handle millions of people coming in to get tested.


Yes agree that testing is necessary but reliable test-kits are hard to come by...(not the made in China ones)


It seems like it is going to get dragged out for a long time the way things currently stand.



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11 Apr 2020, 2:41 am

jimmy m wrote:
Syd wrote:
Experts: COVID-19 pandemic unlikely to ebb as weather warms

https://www.cidrap.umn.edu/news-perspec ... ther-warms


The article you cited states:

An early Chinese study suggesting that, for every 1°C rise in temperature, daily coronavirus cases decreased by 36% to 57% when relative humidity was 67% to 85.5% and that, for[b][i] every 1% increase in relative humidity, daily cases decreased by 11% to 22% when the average temperature was about 5°C to 8.2°C (41°F to 47°F).[/b] "But these findings were not consistent across mainland China," they said.


That's it!
I'm going to get a swimming pool in the back yard,
Get scuba gear and weights.
And get "Unter" to deliver my happy meals underwater.
Let that little virus mutha find me there. :mrgreen:



Pepe
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11 Apr 2020, 2:51 am

eikonabridge wrote:
Trump aides look to punish WHO


I'm not a Trump fanboy.
<in the background>
"The lady doth protest too much, methinks"

W.H.O said that! :evil:
I'm male.
My mother had me tested. :mrgreen:

But getting back to it,
This is the sort of thing that impresses me about Trump.
He pushes back when those afraid of offending the emerging powerhouse, china, "snivellingly" kowtow.



Pepe
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11 Apr 2020, 2:58 am

blooiejagwa wrote:
I swear jimmym my mom was saying the same thing about TB vaccines and all to me 2 or 3 days ago..


Could bloogiejagwa's mother be jimmy m?
Da da da darm.
The conspiracy sickens. 8O

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11 Apr 2020, 4:03 am

Alex Berenson @AlexBerenson
New German data show that 15 percent of people in one region have already been infected with CV (remember - more infections is good news, it means the virus is less dangerous) and the fatality rate is 0.37%.

https://twitter.com/alexberenson/status ... 7942519813


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EzraS
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11 Apr 2020, 4:06 am

I won't be shocked if it turns out to be less and less dangerous over time.



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11 Apr 2020, 4:09 am

EzraS wrote:
I won't be shocked if it turns out to be less and less dangerous over time.

Image


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