Emergence of a Deadly Coronavirus
Novavax Vaccine
The Maryland-based biotech Novavax has announced its COVID-19 vaccine candidate has 96.4% efficacy against COVID-19 illness from the original strain, sliding to 86.3% against the U.K. variant and falling to 48.6% in South Africa amid circulation of another concerning coronavirus variant. However, the jab revealed 100% efficacy against severe disease, including hospitalization and death, in both trials, per final analyses.
Findings from a Phase 3 trial in the U.K. drew from over 15,000 participants aged 18 to 84, 27% of whom were above age 65. Novavax noted 106 cases cropped up, 96 of which occurred in the placebo group. There were five severe COVID-19 cases, all in the placebo group and mostly attributed to the B.1.1.7 variant.
Findings from a separate Phase 2b trial in South Africa drew from about 2,665 healthy adults and 240 HIV-positive, stable adults. The company noted a 55.4% vaccine efficacy among HIV-negative participants.
Source: Novavax COVID-19 vaccine shows 96.4% efficacy, less protection against variants
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Author of Practical Preparations for a Coronavirus Pandemic.
A very unique plan. As Dr. Paul Thompson wrote, "This is the very best paper on the virus I have ever seen."
Progress of COVID Inoculations
According to the coronavirus vaccine tracker, the U.S. has now administered 101.13 million vaccine doses with around 30.4% of the U.S. population vaccinated (with at least one dose). In the United States an average of 2.30 million doses were injected daily.
Globally 345.34 million vaccine doses have been given with the U.S., China and India in the top three positions. India just pass the U.K. India is administering vaccines at approximately twice the rate as China.
Source: COVID-19 Vaccine Tracker
_________________
Author of Practical Preparations for a Coronavirus Pandemic.
A very unique plan. As Dr. Paul Thompson wrote, "This is the very best paper on the virus I have ever seen."
Origin of Covid-19 Virus
Former top State Dept investigator says COVID-19 outbreak may have resulted from bioweapons research accident
"The Wuhan Institute of Virology is not the National Institute of Health," David Asher, now a senior fellow at the Hudson Institute told Fox News in an exclusive interview. "It was operating a secret, classified program. In my view, and I’m just one person, my view is it was a biological weapons program."
"Motive, cover-up, conspiracy, all the hallmarks of guilt are associated with this. And the fact that the initial cluster of victims surrounded the very institute that was doing the highly dangerous, if not dubious research is significant," said Asher, who engaged the Chinese government as the State Department’s lead representative during the 2003 SARS outbreak.
At first, China said the COVID19 virus originated in the Wuhan Seafood Market – but the problem with China's theory: the first case had no connection to the market. Last fall the US obtained intelligence that indicates there was an outbreak among several Wuhan lab scientists with flu-like symptoms that left them hospitalized in November of 2019 - before China reported its first case. Asher and the other Hudson Institute panel experts said that in 2007, China announced it would begin work on genetic bioweapons using controversial "gain of function" research to make the viruses more lethal.
The Chinese stopped talking publicly about their research at the Wuhan lab in 2016. That, Asher believes, is when the People’s Liberation Army stepped in and went from biodefense research to bio-offense. The same year China’s top state television commentator stated:
"We have entered into an area of Chinese biowarfare, and including using things like viruses. I mean, they made a public statement to their people that this is a new priority under the Xi national security policy," Asher points out. "China has been involved in this type of virus research since 2003, the SARS outbreak," according to Miles Yu, the State Department official who co-wrote a recent op-ed in the WSJ with former Secretary of State Mike Pompeo about the virus origins. "China's biosafety standard is really low and is very dangerous. So this is an accident waiting to happen."
The Chinese, according to Asher, stopped talking publicly about the research into coronavirus "disease vectors which could be used for weapons" in 2017, at the same time its military began funding the research at the Wuhan Institute of Virology.
"I doubt that that's a coincidence," Asher said.
_________________
Author of Practical Preparations for a Coronavirus Pandemic.
A very unique plan. As Dr. Paul Thompson wrote, "This is the very best paper on the virus I have ever seen."
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Italy toughens Covid restrictions, imposes Easter lockdown
The country will also be placed under a nationwide lockdown over the Easter weekend for the second year running, the government said on Friday.
Italy, the first Western country hit hard by the pandemic, saw infections rise by 10% this week compared with the week before, and officials have warned that the situation is deteriorating as new, highly contagious variants gain ground.
Under an order approved on Friday by Health Minister Roberto Speranza seven regions have been shifted into the toughest red zones, including Lombardy around Milan, and Lazio around Rome.
Three other regions were already red, meaning half the country’s regions and most of its population will be under the most severe restrictions from Monday.
In these areas schools and non-essential shops will be closed and Italians will only be allowed to leave their homes for work, health or emergency reasons.
The whole country will become a red zone over Easter, from April 3-5, Mario Draghi’s one-month old government ruled.
It was not immediately clear how the new decree would affect churchgoers in the Catholic country. However, it was expected to be similar to provisions last Christmas when people were allowed to go to churches in their neighborhoods.
Unlike last year, Friday’s decree allows for limited visits to friends and relatives over the Easter holiday - for example to see elderly parents.
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Professionally Identified and joined WP August 26, 2013
DSM 5: Autism Spectrum Disorder, DSM IV: Aspergers Moderate Severity
“My autism is not a superpower. It also isn’t some kind of god-forsaken, endless fountain of suffering inflicted on my family. It’s just part of who I am as a person”. - Sara Luterman
Progress of COVID Inoculations
According to the coronavirus vaccine tracker, the U.S. has now administered 107.06 million vaccine doses with around 32.3% of the U.S. population vaccinated (with at least one dose). In the United States. an average of 2.39 million doses were injected daily.
Globally 359.12 million vaccine doses have been given with the U.S., China and India in the top three positions. India just pass the U.K. India is administering vaccines at approximately twice the rate as China.
Source: COVID-19 Vaccine Tracker
_________________
Author of Practical Preparations for a Coronavirus Pandemic.
A very unique plan. As Dr. Paul Thompson wrote, "This is the very best paper on the virus I have ever seen."
Ferrets: Immune Response
A study was done using the H1N1 and H3N2 influenza virus on ferrets. Ferrets have both susceptibilities to seasonal influenza viruses that affect humans and have similar respiratory transmission patterns.
Image courtesy of Michael Sehlmeyer on Pixabay
Simply put, when you are first exposed to a novel antigen, you develop a robust immune response. Subsequently, suppose you are exposed to a similar but not the same antigen. Your immune system relies on its memory rather than go through the process of defending against a new antigen. That immunologic response may or may not be as effective as the response to the original antigen. This original exposure impacts a common respiratory viral disease, seasonal flu.
The study involved ferrets who, like us, are both susceptible to influenza viruses and share them by transmitting viral particles through the air. The researchers were readily able to infect them with two different influenza strains, H1N1, the virus responsible for the 2009 pandemic that primarily affected those age 5 to 24; and the H3N2 virus from 2017 that, like COVID-19, impacts mostly those over age 65. As the numbering suggests, these viruses are similar but not the same.
Both viruses easily spread from the infected to the susceptible, as quickly as a few hours or as long as a typical work week. Half of the ferrets initially infected with H1 were infected with H3 (H1-to-H3), and half of the ferrets initially infected with H3 were similarly infected with H1 (H3-to-H1); in both instances, three months later to mimic a new infection.
* The H1-to-H3 and H3-to-H1 ferrets were then used to infect the remaining ferrets that had only been infected with one of the subtypes.
* The H3-to-H1 “donor” ferrets readily infected the remaining H3 ferrets with the H1 virus – H3 prior exposure conferred no immunologic advantage.
* But this was not the case for the H1-to-H3 “donor ferrets, the remaining H1 ferrets developed no infections at all.
“Taken together, these results indicate that airborne transmission of H3N2 cannot overcome the barrier imposed by H1N1 immunity but transmission of H1N1 can overcome H3N2 immunity …”
Source: [url=https://www.acsh.org/news/2021/03/12/ferrets-morley’s-ghost-and-viral-immunity-15397]Ferrets, Morley’s Ghost, And Viral Immunity[/url]
_________________
Author of Practical Preparations for a Coronavirus Pandemic.
A very unique plan. As Dr. Paul Thompson wrote, "This is the very best paper on the virus I have ever seen."
AstraZeneca Vaccine
Several European countries have suspended vaccinations amid concerns of blood clotting. These countries include: Germany, France, Italy, Denmark, Ireland, Thailand, the Netherlands, Norway, Iceland, Congo, Bulgaria and Spain.
AstraZeneca said there have been 37 reports of blood clots out of more than 17 million people vaccinated in the 27-country EU and Britain. The drugmaker said there is no evidence the vaccine carries an increased risk of clots. In fact, it said the incidence of clots is much lower than would be expected to occur naturally in a general population of this size and is similar to that of other licensed COVID-19 vaccines.
Blood clots can travel through the body and cause heart attacks, strokes and deadly blockages in the lungs. AstraZeneca reported 15 cases of deep vein thrombosis, or a type of clot that often develops in the legs, and 22 instances of pulmonary embolisms, or clots in the lungs.
The E.U. has woven the "precautionary principle" into its governance. But everything has risks. So perhaps they are being blindsided by this destructive philosophy. The proper approach is to perform a risk assessment that balances both positives and negatives.
“Halting a vaccine rollout during a pandemic has consequences,” Dr. Michael Head, a senior research fellow in global health at the University of Southampton in England, said. “This results in delays in protecting people, and the potential for increased vaccine hesitancy, as a result of people who have seen the headlines and understandably become concerned.”
At the moment the E.U. vaccination program is lagging behind. Only 11% of its population is vaccinated with at least one dose of the vaccine. This is in comparison with 32.9% in the U.S.
_________________
Author of Practical Preparations for a Coronavirus Pandemic.
A very unique plan. As Dr. Paul Thompson wrote, "This is the very best paper on the virus I have ever seen."
Progress of COVID Inoculations
According to the coronavirus vaccine tracker, the U.S. has now administered 113.04 million vaccine doses with around 34.2% of the U.S. population vaccinated (with at least one dose). In the United States. an average of 2.47 million doses were injected daily.
Globally 400.35 million vaccine doses have been given with the U.S., China and India in the top three positions.
Source: COVID-19 Vaccine Tracker
_________________
Author of Practical Preparations for a Coronavirus Pandemic.
A very unique plan. As Dr. Paul Thompson wrote, "This is the very best paper on the virus I have ever seen."
Aerosol Transmission
Despite much debate, the evidence is clear —without preventive measures, small aerosol particles in indoor settings can be a primary source of transmission of the COVID-19 virus.
Calls to address aerosol transmission of the virus through enhanced ventilation are not new. Globally-recognized standard setting organization, the American Society of Heating, Refrigerating and Air-Conditioning Engineers (ASHRAE), published a position document in April, 2020, stating “Transmission of SARS-CoV-2 [the virus that causes COVID-19 disease] through the air is sufficiently likely that airborne exposure to the virus should be controlled. Changes to building operations, including the operation of heating, ventilating, and air-conditioning systems, can reduce airborne exposures.”
Concerns with the virus variants are also driving calls to revisit masking requirements. For health care workers and some essential workers, signatories to the above-mentioned Canadian letters urge access to fit-tested respirators (N95, elastomeric or equivalent).
Here in Ontario, wearing a non-medical mask, such as a cloth mask, that covers the nose, mouth and chin is mandatory in almost all public indoor situations and settings across Ontario, including workplaces and businesses outside of health care settings. In these non-health care instances, the Public Health Agency of Canada recommends the use of three-layer non-medical masks. This guidance, however, was advanced before the virus variants first appeared in Canada.
Since then, some European countries have mandated better protections by imposing new masking requirements to enhance public and worker safety. Germany, for instance, is moving away from cloth masks, now requiring medical-grade masks in shops and on public transit. Austria implemented similar requirements for those over 14 years of age on public transit, businesses open to the public, indoor and outdoor markets, even carpooling. The French government announced similar masking recommendations, also citing the need to assure better protection than can be afforded by cloth masks.
Source: Aerosol spread of COVID-19 virus, evidence and experts support urgent action
_________________
Author of Practical Preparations for a Coronavirus Pandemic.
A very unique plan. As Dr. Paul Thompson wrote, "This is the very best paper on the virus I have ever seen."
Progress of COVID Inoculations
According to the coronavirus vaccine tracker, the U.S. has now administered 118.31 million vaccine doses with around 35.9% of the U.S. population vaccinated (with at least one dose). In the United States. an average of 2.46 million doses were injected daily.
Globally 420.54 million vaccine doses have been given with the U.S., China and India in the top three positions. India is vaccinating at about twice the rate of China and may soon overtake them.
Source: COVID-19 Vaccine Tracker
_________________
Author of Practical Preparations for a Coronavirus Pandemic.
A very unique plan. As Dr. Paul Thompson wrote, "This is the very best paper on the virus I have ever seen."
Soliloquist, the video points to the school closing approach not make a lot of sense. I agree. The focus should be on the older folks with comorbidities. They are in the greatest danger for dying from COVID. Generally students will fare fairly well even if they should contract the disease. In my state, the schools have been opened this school year. The schools react if several students contract it but after a couple weeks they are back in operation. They are quite flexible shifting from on site learning to distant learning at home and back and forth. It is a little bit of a balancing act. But it works.
_________________
Author of Practical Preparations for a Coronavirus Pandemic.
A very unique plan. As Dr. Paul Thompson wrote, "This is the very best paper on the virus I have ever seen."
ASPartOfMe
Veteran
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The two developed severe symptoms within 14 days after vaccination, the Capital Region of Denmark, which operates public hospitals, told the Ekstra Bladet newspaper. Use of the AstraZeneca vaccine was suspended in several European countries last week amid reports of blood clots in a small number of patients, but the European Medicines Agency subsequently said the vaccine was safe and effective.
Arkansas Gov. Asa Hutchinson said Sunday he believes his proposal to remove a mask mandate, installed to slow the spread of the coronavirus, will take place as planned at the end of the month.
India has reported its highest number of coronavirus cases in four months amid a worrying surge that has prompted multiple states to return to some form of restrictions on public gathering.
One in four Americans in recent weeks has seen someone blame Asian people for the coronavirus epidemic, a new USA TODAY/Ipsos Poll finds. The nationwide survey was taken Thursday and Friday, in the wake of last week's mass shooting in Georgia of eight people, six of them women of Asian descent.
Florida leads surge of variant cases
Florida on Sunday became the first state to have more than 1,000 known cases of coronavirus variants. The U.S. reported another 834 variant cases since Thursday alone and now has 6,638 known cases, with almost 6,400 of them being of the B.1.1.7 type, the one first found in the United Kingdom, CDC data show.
France, Poland and Ukraine impose new lockdown measures
Residents in Poland, parts of France, including Paris and the Ukrainian capital Kyiv faced new restrictions on Saturday, with most shops shut and people urged to work from home.
The imposition of new curbs comes as the pace of the European Union’s vaccination rollout remains sluggish and several member states face a third wave of the virus.
In France, the government introduced new measures after a jump in COVID-19 cases in Paris and other parts of northern France.
Under the new measures, non-essential businesses in Paris are closed, while schools remain open and outdoor exercise is allowed up to 10 kilometres (six miles) from home.
As in previous lockdowns, a form will be needed to justify why a person has left home in areas under the new restrictions.
“COVID infections have been rising over the last few weeks, nearly 40,000 a day for the last few days, that’s certainly much higher than 10 days ago when it was about 20,000 a day".
“And in Paris doctors say that the intensive care units are nearly saturated, in fact, some hospitals in the city had to fly their patients out of the city to hospitals in different regions of France,” Butler said.
Meanwhile, in Germany, cases are rising at a “very clearly exponential rate”, a top public health institute said on Friday, with many expecting new curbs on work and social life to be introduced in the coming days.
The Robert Koch Institute reported 17,482 new infections in the previous 24 hours and 226 deaths in Germany, with the seven-day incidence rate soaring to 96 per 100,000 people despite a months-long shutdown of large swathes of public life.
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Professionally Identified and joined WP August 26, 2013
DSM 5: Autism Spectrum Disorder, DSM IV: Aspergers Moderate Severity
“My autism is not a superpower. It also isn’t some kind of god-forsaken, endless fountain of suffering inflicted on my family. It’s just part of who I am as a person”. - Sara Luterman
I came across an interesting article on the effectiveness of control measures on the coronavirus.
For decades, the richest nations of the world had told themselves a story in which wealth and medical superiority offered, if not total immunity from disease, then certainly a guarantee against pandemics, regarded as a premodern residue of the underdeveloped world. That arrogance has made the coronavirus not just a staggering but an ironic plague. Invulnerability was a myth, of course, but what the pandemic revealed was much worse than just average levels of susceptibility and weakness. It was these countries that suffered most, died most, flailed most. Gave up most easily, too, acquiescing to so much more disease that they might have been fighting a different virus entirely. For nearly the entire year, the COVID epicenter was not in China, where the pathogen originated, or in corners of South Asia or sub-Saharan Africa, where limited state capacity and medical infrastructure seemed, at the outset, especially concerning, but either in Europe or the United States — places that were rated just one year ago the best prepared in the world to combat infectious disease.
This fact, though not unknown, is probably the most salient and profound feature of what has been a tremendously uneven pandemic with the world’s longtime “winners” becoming by far its biggest losers. The gold-standard responses were those in East Asia and Oceania, by countries like South Korea, New Zealand, and Australia — countries that saw clearly the gravest infection threat the world had encountered in a century and endeavored to simply eradicate it within their borders. Mostly, they succeeded. When it mattered most, no nation in what was once grandly called “the West” even really bothered to try.
In Europe, North America, and South America: nearly universal failure. In sub-Saharan Africa and South Asia: high caseloads and low death rates, owing largely to the age structure of populations. In East Asia, South-East Asia and Oceania: inarguable success. You can compare countries within these clusters, and wonder why Canada has outperformed the U.S. or why Uruguay has outshone Argentina, why Iran suffered so much or how Japan, which never locked down and never tested all that widely, succeeded so brilliantly. But the differences in outcomes between the groups of nations are far greater than those within them, so much so that they appear almost as the burn scars of entirely different diseases.
In East Asia, though, nobody envies the Antipodes. In Taiwan, the death rate is a minuscule 0.42 per million. The European Union performed, on average, 3,000 times worse. Cambodia hasn’t reported a single COVID death all year, and while it is probably fair to assume that the official data don’t tell the full story, what is most startling across East and Southeast Asia — an incredibly heterogeneous region, with wealthy nations and poor ones, democracies and authoritarian regimes, national health-care systems and patchwork networks — is just how consistent the story is. In Vietnam, there have been 0.36 deaths per million, in China 3.36. In Singapore, the number is around five; in South Korea, it is close to 32; in Japan, in many ways the best contrast for the aging and wealthy nations of Europe and North America, it’s about 67. Again, you can doubt some of these numbers, the Chinese figures especially. But in the U.K., remember, the level is north of 1,800.
[The article goes on to say that acting swiftly and decisively played a major role in outcomes. If global travel was brought to a halt and paused at the beginning, the outcome would have improved substantially. In other words once it becomes endemic in the population it is extremely hard to stomp out.]
Mike Ryan, WHO’s executive director of health emergencies spoke at a Geneva press conference on 13 March 2020 and said, “Be fast. Have no regrets. You must be the first mover. The virus will always get you if you don’t move quickly.” “If you need to be right before you move, you will never win. Perfection is the enemy of the good when it comes to emergency management. Speed trumps perfection. And the problem in society we have at the moment is everyone is afraid of making a mistake, everyone is afraid of the consequence of error. But the greatest error is not to move. The greatest error is to be paralyzed by the fear of failure.”
It’s a perspective echoed by Zeynep Tufekci, the scholar of technology who has become perhaps the most treasured “outsider” analyst of the disease and pandemic policy in the U.S. — an independent thinker who has, again and again, called out the limitations and perversities of public-health guidance on everything from masking to asymptomatic transmission to the role of aerosols and the importance of ventilation. She recently surveyed the system’s biggest failures — including that experts sometimes misled the public on key points out of fear that advising them honestly would lead them to take more risk; that hard rules (six feet apart, for no more than 15 minutes) were offered in place of broad principles (“like Japan’s, which emphasize avoiding the three C’s — closed spaces, crowded places, and close contact”); and a preference for false certainty (“There is no evidence of human-to-human transmission”) rather than honest nuance (“There is increasing likelihood that human-to-human transmission is taking place, but we haven’t yet proven this”).
These were not narrowly American issues, or western ones—in fact, much of the problematic guidance came from the WHO. But in East Asia, countries didn’t wait for the WHO’s guidance to change on aerosols or asymptomatic transmission before masking up, social-distancing, and quarantining. “They acted fast. They acted decisively,” says Mina. “They made early moves. They didn’t sit and ponder: ‘What should we do? Do we have all of the data before we make a single decision?’ And I think that is a common theme that we’ve seen across all the Western countries—a reluctance to even admit that it was a big problem and then to really act without all of the information available. To this day, people are still not acting.” Instead, he says, “decision-makers have been paralyzed. They would rather just not act and let the pandemic move forward than act aggressively, but potentially be wrong.”
Source: How the West Lost COVID How did so many rich countries get it so wrong? How did others get it so right?
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Author of Practical Preparations for a Coronavirus Pandemic.
A very unique plan. As Dr. Paul Thompson wrote, "This is the very best paper on the virus I have ever seen."
Regeneron
A combination monoclonal antibody cocktail produced by Regeneron and Roche has shown to reduce hospitalization or death in COVID-19 patients by as much as 70%. The combo therapy, dubbed REGEN-COV, was being evaluated in a Phase 3 trial involving high-risk non-hospitalized COVID-19 patients.
REGEN-COV is comprised of casirivimab with imdevimab, and has already received emergency use authorization from the FDA in the U.S. Under the current EUA, the combo therapy is approved to treat non-hospitalized adults and adolescents with mild to moderate symptoms of COVID-19 and who are at high risk for developing severe symptoms or the need for hospitalization.
The currently authorized dosage is 1,200 mg of casirivimab and 1,200 mg of imdevimab administered together as a single infusion within 10 days of symptom onset.
Source: Regeneron, Roche's antibody cocktail cuts COVID-19 hospitalizations, deaths by 70%, company says
_________________
Author of Practical Preparations for a Coronavirus Pandemic.
A very unique plan. As Dr. Paul Thompson wrote, "This is the very best paper on the virus I have ever seen."
Progress of COVID Inoculations
According to the coronavirus vaccine tracker, the U.S. has now administered 128.22 million vaccine doses with around 39.0% of the U.S. population vaccinated (with at least one dose). In the United States. an average of 2.50 million doses were injected daily.
Globally 468.60 million vaccine doses have been given with the U.S., China and India in the top three positions. India is vaccinating at about twice the rate of China and may soon overtake them.
Source: COVID-19 Vaccine Tracker
In my state, Indiana, they now have lowered the eligibility requirement for the vaccine to age 40+. And next week they plan on lowering it to 16+.
_________________
Author of Practical Preparations for a Coronavirus Pandemic.
A very unique plan. As Dr. Paul Thompson wrote, "This is the very best paper on the virus I have ever seen."