‘Game-changer for autism’: 100-year-old drug reverses sympto

Page 1 of 3 [ 38 posts ]  Go to page 1, 2, 3  Next

friedmacguffins
Veteran
Veteran

User avatar

Joined: 10 Feb 2010
Gender: Male
Posts: 2,539

01 Jun 2017, 2:46 pm

Quote:
‘Game-changer for autism’: 100-year-old drug reverses symptoms, study finds
https://www.rt.com/usa/390222-autism-re ... -symptoms/
Published time: 30 May, 2017 18:08
Edited time: 31 May, 2017 11:19

A drug discovered more than 100 years ago may hold the key to combating autism symptoms, according to a study.

Researcher Dr Robert Naviaux of the San Diego School of Medicine gave suramin, a drug first developed in 1916, to 10 autistic boys between the ages of five and 14, and noted transformative results.

"After the single dose, it was almost like a roadblock had been released," he said. “If the future studies show that there’s continued health benefits, this could be a game-changer for families with autism.”

The study, which has been published in the Annals of Clinical and Translational Neurology, saw five of the participants receive suramin, while the remainder were given placebos. Included in the group were four non-verbal children – two six year olds and two 14 year olds.

“The six year old and the 14 year old who received suramin said the first sentences of their lives about one week after the single suramin infusion,” Naviaux told the UC San Diego Health website. “This did not happen in any of the children given the placebo.”

Inspiration post: Artist sketches incredibly detailed drawings of urban landscapes (PHOTOS, VIDEO) @stwilshirehttps://t.co/PCdhkgq9hIpic.twitter.com/NrJExgFq02
— RT (@RT_com) May 6, 2017

The Centers for Disease Control and Prevention estimates that about 1 in 68 children are affected by autism – which is more than four times more common among boys. The causes of autism, however, are not yet fully understood.

Research has shown that cells harden their membranes in response to attacks from viruses or pollutants. The reaction, known as ‘cellular danger response’ (CDR), is a common defense mechanism that allows cells to wait for danger to pass. Autism is thought to develop during early childhood when cells can become ‘stuck’ in this mode.

New study shows how we can discover genes linked to influenza A disease https://t.co/FsAePgUdCu
— RT (@RT_com) May 7, 2017

Dr Naviaux believes that suramin can ‘un-stick’ the cells by inhibiting the signal they release when they sense danger, which can help normalize the response.

One parent, whose son had not spoken a full sentence in more than a decade, said: “Within an hour after the infusion, he started to make more eye contact with the doctor and nurses in the room. There was a new calmness at times, but also more emotion at other times.”

“He started to show an interest in playing hide-and-seek with his 16-year-old brother. He started practicing making new sounds around the house. He started seeking out his dad more.”

'Army of killer cells': Scientists create viruses that send lymphocytes to identify and destroy cancer https://t.co/bp9ND0qLZk
— RT (@RT_com) May 28, 2017

Suramin was originally developed as a cure for sleeping sickness, a parasitic disease spread by the tsetse fly in sub-Saharan Africa.

First tested on mice in 2013, this is the first time suramin has been administered to children.

For Naviaux, the challenge now is to widen his research to a bigger sample testing size. “This work is new and this type of clinical trial is expensive,” he said. “We did not have enough funding to do a larger study. And even with the funding we were able to raise, we had to go $500,000 in debt to complete the trial.”



ASPartOfMe
Veteran
Veteran

User avatar

Joined: 25 Aug 2013
Age: 67
Gender: Male
Posts: 36,786
Location: Long Island, New York

01 Jun 2017, 3:12 pm

friedmacguffins wrote:
Researcher Dr Robert Naviaux of the San Diego School of Medicine gave suramin, a drug first developed in 1916, to 10 autistic boys between the ages of five and 14, and noted transformative results.

"After the single dose, it was almost like a roadblock had been released," he said. “If the future studies show that there’s continued health benefits, this could be a game-changer for families with autism.”

The study, which has been published in the Annals of Clinical and Translational Neurology, saw five of the participants receive suramin, while the remainder were given placebos. Included in the group were four non-verbal children – two six year olds and two 14 year olds.

“The six year old and the 14 year old who received suramin said the first sentences of their lives about one week after the single suramin infusion,” Naviaux told the UC San Diego Health website. “This did not happen in any of the children given the

For Naviaux, the challenge now is to widen his research to a bigger sample testing size.


Bigger sample size? No f*****g kidding. I see the internet and mainstream media is all abuzz about this potential "game changer". This is the thing that makes me so sick about the state of most autism research today. It seems the world is so desperate to cure (ahem "treat") us that they go bonkers over any suggested link to autism that might lead to a cure (umm "treatments") that any pretense of research standards are not ignored, they are not even considered. And the media on and off line jump at any shread of information like emaciated people bieng thrown crumbs of bread.

Is there any other area of scientific research that is remotely in such bad shape and reported on so badly?


_________________
Professionally Identified and joined WP August 26, 2013
DSM 5: Autism Spectrum Disorder, DSM IV: Aspergers Moderate Severity

“My autism is not a superpower. It also isn’t some kind of god-forsaken, endless fountain of suffering inflicted on my family. It’s just part of who I am as a person”. - Sara Luterman


friedmacguffins
Veteran
Veteran

User avatar

Joined: 10 Feb 2010
Gender: Male
Posts: 2,539

01 Jun 2017, 3:33 pm

I find that NT people tend to count on me, when they are lost or can't fix something, can't remember it, or don't have the patience.

I say that there are certain consequences, people's moods change in a certain time or place, nature does this and that, before a weather event, and they say they have never realized it.

Were I to fixate on emotion -- that means all 100% Normals seem to be half-hearted and disorganized.

I push myself, physically, more (and, luckily, for me, am a quick healer.)

All that being said, suramin is an example of what Timothy Leary called 'cognitive liberty', when discussing illicit drugs. Speaking in the abstract, your frame of mind is just a choice, within your proactive control. He also said (commendably, imo) not to turn people on, against their will.



friedmacguffins
Veteran
Veteran

User avatar

Joined: 10 Feb 2010
Gender: Male
Posts: 2,539

01 Jun 2017, 4:12 pm

We're not supposed to fixate. They take drugs to concentrate. Either condition is a pathology, if you describe it that way.



ASPartOfMe
Veteran
Veteran

User avatar

Joined: 25 Aug 2013
Age: 67
Gender: Male
Posts: 36,786
Location: Long Island, New York

02 Jun 2017, 1:02 am

Autism experts call for further research into 100-year-old drug that could hold key to treating condition

Quote:
Dr Naviaux told CTV News he was “cautiously optimistic that the symptoms of autism are caused by a treatable metabolic syndrome and even children that do have structural changes in the brain can make improvements.”

He is now running a slightly larger trial involving 40 children, and says even if it fails – as is the fate of many early-stage trials – he hopes his experiments could cause a “renaissance in drug development” if a drug that works like suramin is later found.


So if the second trail fails it really might have succeeded. But it is all ok (sarcasm). If you are an autistic child you are considered so "broken" that basic research standards are appearently inconveniences. Desperation does that to sane logical people.


_________________
Professionally Identified and joined WP August 26, 2013
DSM 5: Autism Spectrum Disorder, DSM IV: Aspergers Moderate Severity

“My autism is not a superpower. It also isn’t some kind of god-forsaken, endless fountain of suffering inflicted on my family. It’s just part of who I am as a person”. - Sara Luterman


BTDT
Veteran
Veteran

User avatar

Joined: 26 Jul 2010
Age: 61
Gender: Non-binary
Posts: 7,560

02 Jun 2017, 9:02 am

For Naviaux, the challenge now is to widen his research to a bigger sample testing size. “This work is new and this type of clinical trial is expensive,” he said. “We did not have enough funding to do a larger study. And even with the funding we were able to raise, we had to go $500,000 in debt to complete the trial.”

No money for clinical trial autism research?



ASPartOfMe
Veteran
Veteran

User avatar

Joined: 25 Aug 2013
Age: 67
Gender: Male
Posts: 36,786
Location: Long Island, New York

02 Jun 2017, 9:34 am

BTDT wrote:
For Naviaux, the challenge now is to widen his research to a bigger sample testing size. “This work is new and this type of clinical trial is expensive,” he said. “We did not have enough funding to do a larger study. And even with the funding we were able to raise, we had to go $500,000 in debt to complete the trial.”

No money for clinical trial autism research?


If it is not ABA related appearently not.


_________________
Professionally Identified and joined WP August 26, 2013
DSM 5: Autism Spectrum Disorder, DSM IV: Aspergers Moderate Severity

“My autism is not a superpower. It also isn’t some kind of god-forsaken, endless fountain of suffering inflicted on my family. It’s just part of who I am as a person”. - Sara Luterman


Fogman
Veteran
Veteran

User avatar

Joined: 19 Jun 2005
Age: 58
Gender: Male
Posts: 3,986
Location: Frå Nord Dakota til Vermont

05 Jun 2017, 6:20 pm

Suramin Side Effects:

The most frequent adverse reactions are nausea, vomiting, diarrhea, abdominal pain, and a feeling of general discomfort. It is also common to experience various sensations in the skin, from crawling or tingling sensations, tenderness of palms and the soles, and numbness of hands, arm, legs or feet.[11] Other skin reactions include skin rash, swelling and stinging sensation.[11] Suramin can also cause loss of appetite and irritability.[11] Suramin causes non-harmful changes in urine during use, specifically making the urine cloudy.[11] It may exacerbate kidney disease.[12]:1437–1438

Less common side effects include extreme fatigue, ulcers in the mouth, and painful tender glands in the neck, armpits and groin.[11] Suramin uncommonly affects the eyes causing watery eyes, swelling around the eyes, photophobia, and changes or loss of vision.[11]

Rare side effects include hypersensitivity reactions causing difficulty breathing. Other rare systemic effects include decreased blood pressure, fever, rapid heart rate, and convulsions.[11] Other rare side effects include symptoms of liver dysfunction such as tenderness in upper abdomen, jaundice in eyes and skin, unusual bleeding or bruising.[11]


From Wikipedia Article on Suramin.

It sounds as if the alleged 'cure' is comes with a whole host of unpleasantness, to the point where it's more trouble than it's worth.


_________________
When There's No There to get to, I'm so There!


Kraichgauer
Veteran
Veteran

User avatar

Joined: 12 Apr 2010
Gender: Male
Posts: 48,743
Location: Spokane area, Washington state.

05 Jun 2017, 8:21 pm

Just another autism cure of the week.


_________________
-Bill, otherwise known as Kraichgauer


cyberdad
Veteran
Veteran

User avatar

Joined: 21 Feb 2011
Age: 57
Gender: Male
Posts: 36,036

05 Jun 2017, 8:23 pm

Bought to you by Bayer who make other types of poisons like weedicides and pesticides



Aristophanes
Veteran
Veteran

User avatar

Joined: 10 Apr 2014
Age: 43
Gender: Male
Posts: 3,603
Location: USA

05 Jun 2017, 8:27 pm

Sorry but I view every article that comes out of Russian State Media (rt) with a healthy dose of skepticism, especially when it contains sales pitches like 'game-changer'.



ASPartOfMe
Veteran
Veteran

User avatar

Joined: 25 Aug 2013
Age: 67
Gender: Male
Posts: 36,786
Location: Long Island, New York

06 Jun 2017, 3:44 am

Fogman wrote:
Suramin Side Effects:

The most frequent adverse reactions are nausea, vomiting, diarrhea, abdominal pain, and a feeling of general discomfort. It is also common to experience various sensations in the skin, from crawling or tingling sensations, tenderness of palms and the soles, and numbness of hands, arm, legs or feet.[11] Other skin reactions include skin rash, swelling and stinging sensation.[11] Suramin can also cause loss of appetite and irritability.[11] Suramin causes non-harmful changes in urine during use, specifically making the urine cloudy.[11] It may exacerbate kidney disease.[12]:1437–1438

Less common side effects include extreme fatigue, ulcers in the mouth, and painful tender glands in the neck, armpits and groin.[11] Suramin uncommonly affects the eyes causing watery eyes, swelling around the eyes, photophobia, and changes or loss of vision.[11]

Rare side effects include hypersensitivity reactions causing difficulty breathing. Other rare systemic effects include decreased blood pressure, fever, rapid heart rate, and convulsions.[11] Other rare side effects include symptoms of liver dysfunction such as tenderness in upper abdomen, jaundice in eyes and skin, unusual bleeding or bruising.[11]


From Wikipedia Article on Suramin.

It sounds as if the alleged 'cure' is comes with a whole host of unpleasantness, to the point where it's more trouble than it's worth.


Exception being autism where apparently "by any means necessary" is the ongoing ethical " standard". Scarring or killing you by " bleach enema" is considered worth it because hey it might "recover" you from your dreaded autism.
:(


_________________
Professionally Identified and joined WP August 26, 2013
DSM 5: Autism Spectrum Disorder, DSM IV: Aspergers Moderate Severity

“My autism is not a superpower. It also isn’t some kind of god-forsaken, endless fountain of suffering inflicted on my family. It’s just part of who I am as a person”. - Sara Luterman


B19
Veteran
Veteran

User avatar

Joined: 11 Jan 2013
Gender: Female
Posts: 9,993
Location: New Zealand

06 Jun 2017, 3:51 am

There are some aspects that are really fishy about that article and its claims. I think it's a jack up which the writer perhaps hopes to use persuasively to advance his own enrichment in the future by peddling some "cure".

I notice that the same researcher made the same claims in 2014.

His explanation as to the "cause" of autism is new to me. He's described as a geneticist in the 2014 claim, though the "cause of autism" which he cites (see the OP post) is not a genetic one.

Weird, to say the least.

...

On a more general note, these researchers always ignore/omit any discussion of "construct validity" in terms of their methodology. They do that, perhaps, because there isn't any. These flimsy studies are invisibly premised on the idea that the subjects are all autistic in the same way to the same extent. (If that were the case, they would be clones). We at WP know that is not factual: there are "autisms" rather than "autism", and there are large differences between individuals on the spectrum. Fragile X syndrome confounds many studies too, because that syndrome has often been misdiagnosed as autistic. This flaw of construct validity is not found only in flimsy studies, though it is usually more noticeable in them, where extreme claims are made on the basis of very flimsy "evidence".



CockneyRebel
Veteran
Veteran

User avatar

Joined: 17 Jul 2004
Age: 50
Gender: Male
Posts: 117,539
Location: In my little Olympic World of peace and love

06 Jun 2017, 12:54 pm

I wouldn't touch it with a 30 Ft pole.


_________________
The Family Enigma


friedmacguffins
Veteran
Veteran

User avatar

Joined: 10 Feb 2010
Gender: Male
Posts: 2,539

07 Jun 2017, 3:43 pm

cyberdad wrote:
Bought to you by Bayer who make other types of poisons like weedicides and pesticides


Consider this, in terms of their past association, with eugenics.

I assume that, if you give something to an autistic person, voluntarily, it's a calculated risk,.



friedmacguffins
Veteran
Veteran

User avatar

Joined: 10 Feb 2010
Gender: Male
Posts: 2,539

07 Jun 2017, 3:48 pm

From my perspective, an NT person is putting about 10% of himself, in 10 different places. I feel that I have all the same faculties, just budget my resources, differently. It seems to be a personality trait, more than a disease, in my case.

But, what if you were so fixated, on just one element of your surroundings (let's say a fidget spinner, or the color in a poster) that you could never come out of your shell.