I've lived my entire with a feeling of disconnection from nearly everyone I meet.
No one shares my interests.
But when in doubt of myself, I just look at most of the normal people around me. Most have perpetual expressions of boredom and discontent on their faces. They're always tired, stressed out, and directionless.
I can't remember the last time I felt like that. To someone like me, everything about the world sparks my natural curiosity. It's a fascinating, open playground. I was born to take a certain interest in this world and experience euphoria from perceiving its beauty.
As a kid, I would derive a sustained feeling of joyous stimulation from collections of bottle caps, baseball cards, magic cards, and field guides. It seemed as though regular people needed to climb on roller coasters just to get a few seconds of that same feeling.
That same same sensitivity that allows for the highest highs in life from the smallest of things, also can enable despair of supreme magnitude. I've been there and have thought about ending it several times.
Really you want to stay away from pharmaceuticals at all costs. Those people just want money. And suffering brings them more profit than solved problems. The incentives are not properly aligned.
I think someone here already mentioned weed, but you needn't do anything illegal.
I find green tea and yerba mate produce a definite mood lift, especially when combined with chocolate. Not a hershey's bar, 85% cacao or higher. I'll sometimes nibble on unsweetened baking chocolate just to get in the right mood.
I find the occasional use of tobacco to be immensely euphoric and calming.
I'm not talking about cigarettes.
I like to get a big fat cigar and spend an hour two sitting out on the porch with a book casually puffing away. Smoking a pipe also produces this sort of relaxation.
IPA beers are awesome for relaxation and euphoria. Because of the extra high hop content, a few bottles of a strong IPA gets me effectively 'stoned.'
I find that using quality tobacco, a nice green tea(loose leaf, not weak tea bags), and an IPA all together can really produce a wonderful feeling.
For going to sleep when in mental anguish or under stress: hops, skullcap, chamomile, and valerian are all extremely useful.
Sorry for the thread necromancy, but felt the need to add to this topic.