I've been on Venlafaxine for a few month, the positive effects is that my dark feelings disappeared, I was always thinking about bad stuff, sometimes even wishing that I'll go to bed and never wake up. So the meds worked for me.
The negative effects (they are called antidepressant for a reason), I lost all my libido, and that also included any strength to perform or getting it up, and when it did, simply wouldn't finish. I also gained weight, and had the feeling some of my intellectual capabilities where down, like if I opened a book I'll get tired of reading after 1 or 2 pages, almost if I couldn't read anymore.
So yep, the medication works, but they still suck. So I'll say if we can never use them and try anything else before being put on meds is highly recommended.
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Beauty will save the world -- Fyodor Dostoevsky