Frankly, I doubt you can let go of those desires - you may be able to ignore them though, which I'm not sure is an idea I would support. The prospect of living the majority of your life in loneliness can't feel good, and I wonder if you're sure you have explored all options to feel more connected (although I'm not sure if you're mainly talking about physical connection or mental, or both).
You've had a lot of people tell you they like you in this thread, so if I may ask: does this feel too superficial to you, or is it just not helping much because those people aren't actually in your life?
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What goes on inside is just too fast and huge and all interconnected for words to do more than barely sketch the outlines of at most one tiny little part of it at any given instant. - D.F.W.