In terms of the Club of Rome interpretation, a Little Horn uproots the first 3.
Bio-regions #1,2, & 3, are North America, the West EU, and Island of Japan.
There is a Mediterranean Neighborhood Policy, which just so happens to be numbered EU Rec 666.
If reaffirmed, amongst the many, oblations (sacrifices) would be caused to cease, within 3 1/2 yrs, in fulfillment of Bible prophecy, on account of animal rights, in one possible scenario.