I confess that I have, indeed, seen this cartoon.
I also confess that I have been known to quote that line, in a cartoon voice, quite often, usually following "Which way did he go, George? Which way did he go?" also in a cartoon voice, as a response to "Darryl, did you see where So-and-so went?"
I confess that the lack of amusement on the other person's face is perplexing. 