hiya Rhymes welcome to the club
my experiences started with dysthymia before being dx'ed with AS in 2003. started with norpramin [aka desipramine] which is stimulating, but it lost its effectiveness after about two years of use. then they put me on concerta which was more effective than norpramin but made me cross, so after about a year of that was put on Strattera which hit the spot [made me think clearly like a normal person] but made my GERD worse. since 2005 have not been on any pmeds. some days are more of a struggle than others. the Strattera came on like a lamb in spring, very gentle but after about a week noticed that the clouds lifted and everything was clear, I for the first time in memory just "worked" normally.