Yes! It is definitely related.
I have had endometriosis and it made my whole life..insufferable, because at the time, doctors (male doctors of course) had no idea what that meant.... until recently that I am my ovaries do not produce enough oestrogens... My parents used to say I am lazy. I used to lack any energy for the half of the month and the rest I was trying to rest from the extreme fatigue. Plus the strains of undiagnosed autism, made me want to close myself all day in a dark room. The doctors used to send me away with contraceptive pills and antidepressants, until the cyst bursted and almost died. As a result endometriosis was also causing me severe depression. I also suffered from horrible acne. So maybe yes, we have less tolerance to oestrogens.
Maybe one of our sensory sensitivities, include estrogens. That is my experience.
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"All of humanity's problems stem from man's inability to sit quietly in a room alone"
Blaise Pascal, Pensées (Thoughts)