Yes. I am (reluctantly) driving an automatic now, because manuals are becoming too hard to find and also too expensive to repair. I started out driving a stick because the car I had my heart set on had one, and even though I had no experience driving one, I made myself learn. All my cars since until this last one have been sticks. I am glad that I learned out even though there were a lot of people who predicted my failure when I bought my first car. They said, What if you can't learn? and I said I had a lot of money invested, I had to learn. It was tricky at first, but I actually liked the hand-foot coordination, it gave me something to do. Besides I did not know I was Aspy, so I did not know I was not supposed to be able to do it.
Moral of the story, just because something might be more difficult for some of us because of ASD does not mean it is impossible!