Oxytocin: The Asocial Cure? (TIME mag)

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I don't see how increased dopamine would affect the serotonin receptors. people who abuse cocaine don't have problems with serotonin.

did you mean block the dopamine receptors? i highly doubt anyone would administer something that destroys dopamine receptors, that would be a very, very bad thing.

i don't think that would be the biggest problem. there are PLENTY of drugs that have high abuse potential that are regularly prescribed. stimulants for adhd (Methylphenidate, Dextromethamphetamine, Amphetamine, etc), opioids as painkillers (oxycodone, codeine, morphine, etc.), sedatives, etc. all have high abuse and addiction potential, yet are routinely prescribed. there are people who falsify documents, fake illnesses, etc to get these drugs, so it's nothing new.


to do this they could just have a drug comprised of a stimulant, an snri, and an oxytocin reuptake inhibitor. the only one i don't think they have is the oxytocin reuptake inhibitor, so they're two thirds of the way there.

i don't think it would have the same crash as the higher doses of mdma. the stimulant i'm taking for my adhd does the same thing as cocaine, releases dopamine (sort of, but i won't bother clarifying), but i don't get the same crash, even at a somewhat high therapeutic dose. they could easily put the drug in an extended release form that you take at the beginning of the day and it wears off toward the end of the day (like mine) so as you're settling down for the end of the day you're also coming off the meds so it doesn't impact you as severely as instant release.

Yeah well, I am aware. My medication (72mg Concerta XL) down is pretty shi-tty at times. For instance at times I just feel incapable and as if my thoughts are 'blocked' and I feel depressed and blank, other times I get abit irritable, although it does depnd other times I feel this sort of slow dip.

Well for one if I remember all that well it was an animal study, not a human study. And hell I'm not a neuroscienctist and I don't have the pretensions to think I am- I did point out I maybe incorroect, or hell the book maybe incorrect. Although I have just found this page that might be helpful. http://www.mdma.net/toxicity/dopamine.html.


Ofcourse I am aware of this, an example is some C U Next Tuesday I know who claims he gets prescribed Methadone for an arthritic hand condition he doesn't have that they apparently can't prove he has or hasn't.
However with MDMA it is different, it was made illegal just about the time there was interest in it's clinical use. Also when they consider to use it for psychotherapy, the patients are monitored and in controlled settings- it wouldn't be like they walk out of an office with 120mg of Mandy.

[/quote]ramsamsam wrote:
So I guess it's up to researchers to find a chemical that is not known to have much of an abuse potential (yet), that releases just enough Oxytocin, maybe some seritonin, some dopamine, and maybe noradrenaline. Infact if they can fnd a fairly safe chemical with all that, then it could probably be used to treat alot of mental health difficuties ranging from Attention Deficit Disorders, Depression, and maybe some personalitie disorders.

to do this they could just have a drug comprised of a stimulant, an snri, and an oxytocin reuptake inhibitor. the only one i don't think they have is the oxytocin reuptake inhibitor, so they're two thirds of the way there.the stimulant i'm taking for my adhd does the same thing as cocaine, releases dopamine (sort of, but i won't bother clarifying), [quote]
Presumably you're probably on Methylphenidate, although it could be Dexedrine, Adderall or Desoxyn. If it is methylphenidate you could also say it works in a similiar way to Nicotine, as Nicotine is a dopamine reuptake inhibitor. Methylphenidate is more like that of Amphetamines in terms of structure, and in fact related to even MDMA, and 2c-i (they're all phenethylamines). Perhaps the man reason why it is often compared to Cocaine is the shock it brings in people (it would seem likely that a scientologist first compared the two to shock parents and to get people to oppose to the idea of it treating anyone with it) and also Methylphenidates short duration of effect and short half life (about 2-4 hours compared to about 12- 30 hours for amphetamines), also like Cocaine apparently when large doses of Methylphenidate are consumed with ethanol it undergoes a conversion in the body to another substances, in methylphenidates case it becomes Ethylphenidate, which apparently releases more dopamine, and explains to a large extent why when i used to get drunk on it I would really loose control.
Although I have read that alledgedly when abused methylphenidate can produce a similiar high to cocaine, although I wouldn't know as i've never tried cocaine, and wouldn't actively seek to use it.
Anyway blah, I get things wrong some times, and this maybe one of those times. But in the words of some guy talking on The Fall song 'Who Makes The Nazis' "MURDER ALL BUSH MONKEYS!", which yeah that's a very convincing argument for anything.

they do Alzheimer studies with it.... it helps people remember things better by strengthening emotional attachments to thoughts.

I really think that there needs to be a lot of research into MDMA and its benefits to autistics. It seems clear that it is beneficial, but possibly not something you can take on a regular basis. Research needs to find a similar drug that can be taken regularly without the memory loss issues.

I went to the Dr. today and asked for an oxytocin test. They called the lab, but the lab doesn't offer it. They are also checking me for heavy metals - lead, mercury, copper, and arsenic. I'll report back if they find anything.

they make 72mg concerta now? i'm on 54's


true, but if they found an effective oxytocin reuptake inhibitor they could combine those to get the effect you were looking for. i think the chances are much lower of finding something that does all three because of the vast difference in chemical structure they have.

yup i'm on methylphenidate, similar in structure to amphetamines but similar in effect to cocaine. the biggest difference between cocaine and methylphenidate is the time it takes for the dopamine transporters to be blocked, and how long they stay blocked. there was a study where researchers gave equivalent doses of cocaine and methylphenidate intravenously to a number of subjects and they found that the cocaine acted more quickly (something like 5 seconds as opposed to 10 or 15, can't remember exactly) so the high was more noticeable, and the transporters were blocked for 30 minutes with coke, whereas they were blocked fr 90 with methylphenidate, despite the effects lasting the same amount of time. this means that after 30 minutes on coke you're ready for another dose, whereas on methylphenidate it takes 90 minutes, so it's easier to binge on coke and get addicted than it is on methylphenidate.

about the drinking on concerta, i find i can drink a lot more when i'm on in than when i'm not. it also makes me more aware when i'm drinking, so i get the inhibitions removed but i also think more clearly. it also keeps me awake longer, which is a definite plus at parties.

Firstly I would like to address this very interesting thread. Oxytocin is indeed released, by the Anterior Pituitary Gland (in the bottuck) during orgasm. Well that is to say, for women, apparently. That's what they say. I'm very interested to know more about what women experience physiologically during orgasm. For a man though, Oxytocin is pumped throughout the body during stimulation and ejaculated out of the body, along with the semen. So as it may relax us, it also depletes our capacity and interest for further connection. (Sound familiar fellas?).

Now this from another thread I contributed to -

Oxytocin (excuse my laymans understanding) is pumped throughout the body by the Anterior Pituitary Gland (yes it is in the buttock). It aids in the transmission of all plasmas throughout the body (there are ten I think). It is responsible for the feelings of connection between members of the same species and as other people have indicated, other mammals. They have Oxytocin as well.

The APG requires Magnesium and Essential Fatty Acids to operate well. (We all know the "feel good" effects of Magnesium and EFA's. This is because the fluids are moving more effectively throughout the body). One of the most noticeable plasmas is the sexual fluids. When we feel connected obviously the production of sexual fluid increases. This is the effect of Oxytocin. The interesting thing about it is the more you get the more you desire connection and the less you get the less you wish to be near people. Sound familiar?

So we find ourselves in a catch-22 situation with regards Oxytocin. This is where diet comes in. (But there are sooo many other ways of increasing Oxytocin. If anyone is interested, I would love to share my research). I am personally focussing my efforts on diet, believing that the increase in Oxytocin will increase my tolerance and eventual desire for human company. And it is slowly working too!

If I can share a few easy ways with you: warmth (a warm bath, warm climate, soft music, warm colours, warm water rather than cool, pets, doing what you enjoy, sunlight of course, broad spectrum indoor lighting); Essential Fatty Acids (coconut oil is a miracle! but cold pressed organic oils generally, especially sesame and sunflower, avocado but only if you're digestion is good, warm nut mylks, organic Epsom salt baths); most importantly though minerals (Magnesium, Calcium, Potassium, Sodium, Zinc). Do not underestimate the importance of these Alkalising minerals. We are not machines. We have natural requirements. Magnesium and Calcium are particularly important to a functioning Anterior Pituitary Gland.

I am extremely interested in discussing this with anyone further as I have dedicated myself to it and my own healing.

WRONG! The pituitary gland is a protrusion off the bottom of the hypothalamus at the base of the brain.


WRONG! There is only one plasma - blood plasma.

If you are doing any "research" on this hormone, then your obvious errors and ignorance of human physiology lead me to believe that you have little or no formal training in medicine, biology, or endocrinology. Thus, any advice you give on this matter may be suspect.