I say no.
I try to steer clear of drama queens and very reactive people, and *usually* I can tel when I'm being manipulated.
In the past, this wasn't always true.
If you can tell, I think it's fine to acknowledge it with the person who's manipulating you even if this is considered weird. Just outright tell them that you know what they're doing (without sounding too paranoid or they will try to turn it around on you) and that you won't deal with it.
They are the ones in the wrong, they will probably either stop what they're doing or pretend they don't know what you're talking about. If they do, I would definitely isolate myself from that individual if possible.
I've become hyperaware and paranoid in the past because I can be manipulated by others, it can be difficult to prevent this if you are manipulated on a continuous basis, my advice is to give most people the benefit of the doubt until you have real reasons to be suspicious of them.