I have AS, just recently self diagnosed.. and ive worked with special needs children for 20 years.> YES u can teach with AS but,,, and this is a huge but,,,,the district politics and site politics will be the issue,< NOT the kids and if u happen to get a couple of administrators that tis little game is important to them, they can break you. Its not the kids,, kids love me,, I now work as a sub Teacher aide taking special needs classes.. as a sub no one expects me to join in to the social scene,, something to think about,, the worst part of teaching is not the kids,, its the administrators u have to deal with.