Okay, so maybe it's become a cliche. I'll try to be a little more interesting about my self-advocacy.
The "hard-wired" argument, for me, is mostly that if something is intrinsic to the structure of my brain, it's not something that can be changed easily. At my age, it probably can't be changed at all, short of brain surgery to simply cut it out. I can learn new things, and that changes my brain subtly, by changing the amount of and sensitivity to neurotransmitters, and sometimes even forging new connections between neurons. Call that the "software" I'm running on my brain. My knowledge of the multiplication tables, for example, is only a very peripheral part of my identity. However, my ability to process numbers is "hard-wired". Very early in my life--perhaps even prenatally--I got the foundation for understanding the concept of amount. On that, all of my knowledge about mathematics is based. (I say this because experiments on very young infants do show that they have a concept of amount, a very rough one, to start out with.) How I process ideas about amount is much closer to my identity than my having memorized the multiplication table.
Now consider that autism doesn't just affect one such tiny hard-wired thing, but all of them. Not just amount, but language, sensory processing, cognition itself, is different because I am autistic. We're not talking about learning multiplication tables here. If the brain were a computer, curing autism wouldn't be a matter of installing new software; it would mean replacing all the circuits with different ones that work differently. If you know computers, that means that essentially you have a different computer. And good luck keeping the software you used for the old computer to work on the new one. It won't work--you won't be able to access the data. In terms of the human brain, with hardware and software all interconnected, the old data would simply have had to be destroyed. You would be a blank slate--a neurotypical infant in an adult's body. You would no longer be yourself.
Even if I hated being autistic, even if I thought it was the worst thing in the world, I still couldn't choose that sort of a cure. It would mean destroying the person I am, and I prefer existence to oblivion. Thankfully, our scientific knowledge is nowhere near that advanced, and quite possibly never will be.
There are solutions other than "cure", which we should be pulling for. Better education. Better accommodations. Acceptance.
For those of you who want a cure, I ask: If you could be happy, accepted, doing useful work in a world where you could fit in, would it really matter if you were still autistic? Because I find that a much more reasonable goal.