bizarre wrote:
So what is schizotypical disorder? Is it a mild form of schizophenia? Like Aspergers is a mild form of Autism. Is it neurological or is it a personality disorder like NPD or Borderline?
I think technically it is part of the schizphenia spectrum. Also all major personality disorders might have some neurolgical basis to.
Quote:
: Prog Neuropsychopharmacol Biol Psychiatry. 2007 May 10; [Epub ahead of print]
Links
Prevalence of large cavum septi pellucidi and its relation to the medial temporal lobe structures in schizophrenia spectrum.
Takahashi T, Suzuki M, Hagino H, Niu L, Zhou SY, Nakamura K, Tanino R, Kawasaki Y, Seto H, Kurachi M.
Department of Neuropsychiatry, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan; Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Tokyo, Japan.
Magnetic resonance imaging was used to evaluate the prevalence of the cavum septi pellucidi (CSP) in 154 schizophrenia patients, 47 schizotypal disorder patients, and 163 healthy controls. We also explored the relation of a large CSP (>/=6 mm) with medial temporal lobe structures. No significant difference was found in the prevalence of the CSP (76.0% of the schizophrenia patients, 81.6% of the controls, and 85.1% of the schizotypal patients) or the large CSP (6.5% of the schizophrenia patients, 7.4% of the controls, and 10.6% of the schizotypal patients) among the groups, but patients with a large CSP (10 schizophrenia and 5 schizotypal patients) had smaller volumes of bilateral amygdala and left posterior parahippocampal gyrus than patients without it. In the control subjects, the large CSP did not affect the volumes of the medial temporal lobe structures. These findings might reflect neurodevelopmental abnormalities in midline and associated limbic structures of the brain in schizophrenia spectrum.
PMID: 17553605 [PubMed - as supplied by publisher]
Quote:
1: Schizophr Res. 2007 May;92(1-3):32-40. Epub 2007 Mar 23.
Links
Associations between schizotypal features and indicators of neurological and morphological abnormalities.
Bollini AM, Compton MT, Esterberg ML, Rutland J, Chien VH, Walker EF.
Emory University School of Medicine, USA.
[email protected]OBJECTIVE: Limited research suggests that subtle neurological and morphological abnormalities that have been documented in patients with schizophrenia also may be associated with schizotypal traits in non-psychiatric samples. Based on the notion that neurological soft signs (NSS) may mark a genetic diathesis, this study hypothesized that NSS scores would be related to the level of schizotypy in relatives of schizophrenia patients and in controls. Additionally, associations between MPA scores and schizotypy were explored in these two groups. METHOD: Twenty-six first-degree relatives of schizophrenia patients and 38 controls with no personal or family history of psychosis were assessed for schizotypy using the Structured Clinical Interview for DSM-IV Axis II Disorders schizotypal personality disorder module, as well as the self-administered Schizotypal Personality Questionnaire. The Neurological Evaluation Scale and a structured examination for MPAs also were administered. RESULTS: Mean schizotypy scores did not differ between relatives and controls. Both NSS and MPAs were associated with the level of interviewer-assessed schizotypal features in controls but not in relatives of patients with schizophrenia. NSS and MPAs were not associated with self-reported schizotypy in either group. CONCLUSIONS: These findings demonstrate that both NSS and MPAs are associated with interview-based schizotypal traits, at least in non-psychiatric participants. Future research should seek to replicate these results in other samples of relatives and controls.
PMID: 17363219 [PubMed - indexed for MEDLINE]
Last edited by TheMachine1 on 25 Jul 2007, 1:33 am, edited 1 time in total.