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Science Vault: 60s Flashback, LSD as a Treatment for Autism

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jijin
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09 Oct 2007, 1:50 pm

http://scienceblogs.com/retrospectacle/ ... ack_ls.php

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Its been a few weeks since anything truly old and shocking as come across my plate as fodder for my 'Science Vault' series, but when I saw this paper, I knew I had to blog it. Basically, it is a 2007 paper by Sigafoos et al, published in Developmental Neurorehabilitation, which describes efforts in the 1960s and 1970s to treat autistic children with d-lysergic acid diethylamide (LSD). A series of studies took place from 1959-1974, which involved administering LSD to children at school and cataloging their behavior. Beyond illustrating that the therapy didn't work, it reminds us what a different place science was then.


Just a little more crappy things done to Autistic people. In this case it's really bad as it's kids.


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Asparval
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09 Oct 2007, 1:53 pm

jijin wrote:
Just a little more crappy things done to Autistic people. In this case it's really bad as it's kids.


I did that to myself back then 8O



edal
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09 Oct 2007, 2:01 pm

Well, they say that if you remember the 60's you weren't really there.

Peace, man.

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nexus6
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09 Oct 2007, 2:03 pm

As misguided as the LSD effort was it seems that sometimes unusual or dangerous drugs can lead to breakthroughs. Recently scientist have been experimenting with Ketamine, a powerful anesthetic and hallucinogenic street drug (related to PCP) and found it will relieve depression instantly. This lead them to find evidence that problems with the neurotransmitter Glutamine is the primary cause of depression and maybe other disorders. Now they plan to develop more targeted drugs that work with out the head trip.

So, yes giving children LSD is morally unacceptable and typical of 1960's thinking, it shouldn't lead us to shy away from real research using street drugs, especially for informed adult patients.



eet_1024
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09 Oct 2007, 2:50 pm

nexus6 wrote:
This lead them to find evidence that problems with the neurotransmitter Glutamine is the primary cause of depression and maybe other disorders.


FYI, Glutamine is not a neurotransmitter.

Science Vault wrote:
10 boys and 2 girls were given varying doses of LSD (either 50,100,or 200 mg)

That's like 10 to 200 times the lethal dosage.



poopylungstuffing
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09 Oct 2007, 6:36 pm

funny....I have found that a very small dose of LSD will make me um...how-you-say...less neurotic....not that i do that stuff very often....
but it has been known to make me more relaxed, open, social, and focused.

I am not implying that LSD is good for autism or anything...i have just had positive experiences with it meeself.


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ev8
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09 Oct 2007, 7:05 pm

eet_1024 wrote:
Science Vault wrote:
10 boys and 2 girls were given varying doses of LSD (either 50,100,or 200 mg)

That's like 10 to 200 times the lethal dosage.

The LD-50 of LSD is around 12 milligrams. LSD is generally measured in micrograms, it's likely that it was a simple error. After all, there's no μ key on the keyboard.



monty
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09 Oct 2007, 7:48 pm

eet_1024 wrote:
nexus6 wrote:
This lead them to find evidence that problems with the neurotransmitter Glutamine is the primary cause of depression and maybe other disorders.


FYI, Glutamine is not a neurotransmitter.



Another typo? Glutamate is a neurotransmitter that hits the NMDA receptor. Glutamate/NMDA problems may be one cause of depression, not sure that it is the primary cause. Glutamate is also an amino acid.



woodsman25
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10 Oct 2007, 10:08 am

ev8 wrote:
eet_1024 wrote:
Science Vault wrote:
10 boys and 2 girls were given varying doses of LSD (either 50,100,or 200 mg)

That's like 10 to 200 times the lethal dosage.

The LD-50 of LSD is around 12 milligrams. LSD is generally measured in micrograms, it's likely that it was a simple error. After all, there's no μ key on the keyboard.


START ---> Accessories ---> system tools ---> character map

Well... everybodys setup is different, their is symbols that can be used, pretty much any symbol anywhere is your windows updates itself almost daily. Not that its anybodys fault on here, its the authors, but if anybody ever wondered, thats how you access these symbols and how to 'type' them.

Also, I hear about this in collage, pretty crazy thinking, I wonder if Tim Leary came up with this notion. I have tryed LSD in collage, gotta say it was interesting, and nothing bad happened thankfully, i felt in control, but did not want any socalization at all, all I wanted to do was walk in the woods and be alone all day, and think, and walk, and think ect ect...


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10 Oct 2007, 1:05 pm

I'm all for exploring the mind with guidance and supervision - in a sacred way - the way the Natives do it, with purpose and divine intent. So I would do MDMA, Ibogaine, Ayahwasca, Peyote - in an instant given the right parameters - people, surroundings and general good state of health. Definitely it's a tool to be used in healing.



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10 Oct 2007, 1:09 pm

poopylungstuffing wrote:
funny....I have found that a very small dose of LSD will make me um...how-you-say...less neurotic....not that i do that stuff very often....
but it has been known to make me more relaxed, open, social, and focused.

I am not implying that LSD is good for autism or anything...i have just had positive experiences with it meeself.


I had the exact same experience using mushrooms - I took a small dose of some relatively benign magic - and felt the most normal I have ever felt in my entire life. It was as if the entire wall separating me from the world was lifted. I could communicate, relate, empathize. And people really responded beautifully back as well.



eet_1024
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10 Oct 2007, 1:20 pm

ev8 wrote:
eet_1024 wrote:
Science Vault wrote:
10 boys and 2 girls were given varying doses of LSD (either 50,100,or 200 mg)

That's like 10 to 200 times the lethal dosage.

The LD-50 of LSD is around 12 milligrams. LSD is generally measured in micrograms, it's likely that it was a simple error. After all, there's no μ key on the keyboard.


As a Ph.D. Candidate, I would have expected that the author would have been exposed to the convention of abbreviating micrograms as ug. In addition, I would have expected that she would have recognized that mg as the conventional abbreviation for millgrams, not the intended micrograms.



monty wrote:
eet_1024 wrote:
nexus6 wrote:
This lead them to find evidence that problems with the neurotransmitter Glutamine is the primary cause of depression and maybe other disorders.


FYI, Glutamine is not a neurotransmitter.



Another typo? Glutamate is a neurotransmitter that hits the NMDA receptor. Glutamate/NMDA problems may be one cause of depression, not sure that it is the primary cause. Glutamate is also an amino acid.


I hadn't heard about the Glutamate system.



psych
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10 Oct 2007, 2:38 pm

jjstar wrote:
poopylungstuffing wrote:
funny....I have found that a very small dose of LSD will make me um...how-you-say...less neurotic....not that i do that stuff very often....
but it has been known to make me more relaxed, open, social, and focused.

I am not implying that LSD is good for autism or anything...i have just had positive experiences with it meeself.


I had the exact same experience using mushrooms - I took a small dose of some relatively benign magic - and felt the most normal I have ever felt in my entire life. It was as if the entire wall separating me from the world was lifted. I could communicate, relate, empathize. And people really responded beautifully back as well.


Did the benefits dissapeer the next day or last for a while afterwards? Psychedelic relief from OCD symptoms is said to last for weeks to months after a single administration.



jjstar
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10 Oct 2007, 2:42 pm

No. It just really gently and smoothly wore off in about 5-6 hours.


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poopylungstuffing
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10 Oct 2007, 6:18 pm

likewise...

(sometimes I can feel sorta cruddy later on though)


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10 Oct 2007, 6:28 pm

just for those who are interested in the history of lsd check this link out http://www.levity.com/aciddreams/tripguide.html

when reading it check ever link for it will have more for you to read and it will take awile to read it

think im going to get the hole book


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