Resistance to sedatives and AS

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Link to the source at Aspergerfoundation.org.uk

I've not seen "resistance to sedatives" mentioned in relation to AS before, and they don't really clarify what they mean by the term. I just wondered is this is something people here have experience of/with.

or maybe whether this has implications with medications taken for comorbid (really hate THAT word) disorders. I've always refused any other meds I've been offered. The only sedatives I've had much experience with are alcohol and sleeping pills. sleeping pills just gave me hallucinations, and I guess it does take a lot to get me drunk, but I attributed that to my body size.

I don't know if that's their point, but I'd like to hear your opinions or your take on this.
or if anyone knows of their source for this info, maybe a heads-up in the general direction.

Alcohol doesn’t bother me
I gotta take a high dose of Valium/Xanax to feel relaxed

High anxiety state plus weird brain equates to this I'm assuming.

I know that I have had resistance to some sedatives....I will get insomnia from drinking sleepytime tea...
I once was put under for minor surgery as a teenager and the nurse asked if I was on drugs because I was so resistant to the sedative.

I thought this was an ADD thing for some reason.....hmmm...

I can tend to have problems with diet alcohol

I get tired on caffeine, which is odd...

But in hospital, they had to give me 2/3 different sedatives before I calmed down, and on top of that, a strong sleeping pill to get me to sleep afterwards. All the anger and shouting etc got me physically exhausted, but getting myself to sleep was very difficult.

I was on 10mg olanzepine and 3mg clonazepam, but still had trouble sleeping. Now I sleep 8 hours a night because I've fallen into a strict routine of bed 10pm and wake up for school 6am.

I need a higher than average dose of EVERYTHING, from simple aspirin to stronger drugs. I have never been able to get drunk either.

I'm self-diagnosed, so you take this how you want.

When I was about ten my GP gave me an EEG (for my migraines among other things going on with me) and they gave you Valium back then before they did it so you would be relaxed. He gave me 3X the adult level in the end and I still was not relaxed. When I had Lasik done, the same thing happened. I am highly resistant to tranquilizers, sedatives and pain medication (all of which are supposed to have a drowsy effect). I can also put away the alcohol without feeling drunk (I'm talking 10 Black Russians in a few hours which is nothing but Vodka and Kahlua).

I think the sleep is related to insomnia which I have from time to time. My mother told me I rarely slept even when I was a baby. I'm not sure about the food. I don't have a sense of hunger and have to be reminded to eat. I also don't have much of a sense of taste, except for things that seem so strong that I can't stand to eat food with those things in them. I think those are all messed up sensory signals myself. At least that is what makes sense to me.

I would think these are co-morbids. Did it say they were?

I'm not sure. I used to use Xanax and easily got addicted to it (while taking Valium at the same time for a while), but a moderate dose would make me pass out for 12 hours straight. I'm slightly ashamed to admit that there was a time in my life where the highlight of my weekend was being able to take sedatives and pass out.

And only a couple drinks make me completely drunk. I used to like mixed drinks, but now I only drink wine and I even have to limit that to 2 glasses or I'll get drunk.

I always assumed it was because I don't weigh alot, or because I don't take many medications and have a low tolerance to anything.

I've been on vicodin lately for a tooth problem and instead of making me sleepy, it seems to make me quite hyper... VERY loopy and a bit slow, but hyper nonetheless-I don't get that sleepy effect most people get with it, instead I am WIDE AWAKE.

Same with sleep meds-when they actually do help, I have to take 3 usually instead of one to finally fall asleep or hit a point where I can, but I still wind up waking up 2-3 hours after laying down if I take them and I'm up for the rest of the day/night.

I always wondered about this before I realized I had AS. I would drink relatively heavily (during one brief period of alcohol experimentation) with literally no effect. I would pour an entire (small) glass of jack daniel's, not realizing my mom heavily diluted hers with water, lemonade, and ice cube, and drink the entire thing with no effect. I might get a small headache, but that was it. Whenever I take sleeping pills and the like they have no effect on me. I always thought that it was probably because most people who take them, take them expecting certain results and are mostly affected psychologically by them, whereas I wasn't quite sure what to expect so they never did for me what they did for others.

Benzos knock me right out even in small doses.

i can drink coffee and go straight to bed no problem...

not sure about the other direction...

I remember those sleeping pills well lol.
I alsways had to take them on a totally empty stomach or they'd barely work.
Some days if i took them at 11 after eating at 5 i'd get hit pretty hard by them.
It made me do things and not care about things 10 times more than any amount of alcohol ever could.
It instantly took away the social barriers of AS.

I have weird reactions to some drugs. Like a lot of the time, local anesthetics have no effect. Novocaine used to have no effect on me. Then, my dentist got a new kind, and it was supposed to numb my mouth for an hour, but it numbed it for eight hours instead.

Also, when I had my wisdom teeth out, they gave me Versed, I guess it's some kind of sedative. Anyway, after Versed you're not supposed to have any memory from when you were on it (that's just a side effect), but I remembered the entire experience. Not that that is a bad thing, but it's just weird that it didn't have the usual effect on me.

I once took aspirin until I had TINNITUS! It STILL didn't help my headache. The ONLY thing that works is 800mg of IBUPROFEN! Sedatives apparently work, but ONLY real ones. I have ODed on the store ones sold now, and they don't even make me drowsy. There are about 4 different ones, and I have tried them ALL!

Steve

I just remembered something else...when I was 5 some kid tripped me at kindergarden and I cracked my head open on the corner of the pavement

When I went to hospital I was given a massive dosage of sedatives (it was a very deep wound) and my mother was told I would be unconscious for many hours. Immediately as the doc turned around and left the room I looked up at my mom and said "You have four eyes" (I remember doing this - I had double vision). So much for the tranqs!

I never really needed much in terms of sedation for pain, because I just don't really feel pain unless the wound is sickeningly bad (i.e. torn-up skin through all the layers). I've been kicked in the shins with steel-tipped boots, punched so hard I blacked out and am naturally clumsy so I get hurt a lot. But in all those occassions, I just got up, dusted myself down and was fine. The only organ in my body that ever gives me real pain is my stomach, but I blame hereditary things for that.
If I do take painkillers, I just get very high. Once I was given morphine, and I was physically cartwheeling down the corridors, just after an ear operation!