Cause of Autism Allegedly Found

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Zur-Darkstar
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16 Dec 2010, 12:30 pm

MidlifeAspie wrote:

jamesongerbil wrote:

That's odd that it was said to be a Mitochondrial disorder, but not genetic. After all, the mitchondria houses RNA, which happens to be transferred from the mother.

Mitochondrial DNA only comes from your mother and 80% of Aspies are male. If MDNA was the carrier for the Aspergers gene you wouldn't see it trending in the male populations within a family as none of your MDNA comes from your father. I'm sure that it is much more complicated than this - I haven't taken a genetics course since the mid-nineties.

This was the same thought I had as well. If the cause is the DNA in the mitochondria of the mother, then all children, male and female, should be equally affected.

wavefreak58
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16 Dec 2010, 12:56 pm

Zur-Darkstar wrote:

MidlifeAspie wrote:

jamesongerbil wrote:

That's odd that it was said to be a Mitochondrial disorder, but not genetic. After all, the mitchondria houses RNA, which happens to be transferred from the mother.

This was the same thought I had as well. If the cause is the DNA in the mitochondria of the mother, then all children, male and female, should be equally affected.

Not necessarily. The hormone profile of a male is different than a female and could lead to a different expression of MDNA genetic information. It could also be possible that a synergistic combination of variations in both MDNA and on the Y chromosome leads to more autism in males. MDNA anomalies might be necessary for autism without in any way being sufficient.

Sounds like further study is needed.

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wavefreak58
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16 Dec 2010, 1:06 pm

Besides, this guy is late to the party.

ALL the answers are here:

NewAutismCure.com

:roll: :twisted: :roll:

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DandelionFireworks
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16 Dec 2010, 1:53 pm

In what way would that be sufficient? Anyway, now you're making me worried; I've been thinking I'll use myself as a guinea pig and see whether this actually means anything important. But if there's a chance it's a cure, I'm not sure I want to take the risk.

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starygrrl
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16 Dec 2010, 1:58 pm

MidlifeAspie wrote:

jamesongerbil wrote:

That's odd that it was said to be a Mitochondrial disorder, but not genetic. After all, the mitchondria houses RNA, which happens to be transferred from the mother.

80% of diagnosed aspies are male. Diagnosed being the operative word, truth is it is probably closer to 50/50. Remember most people being diagnosed with NVLD these days are women, and they suspect many women who are diagnosed with OCD and Bipolar may have been misdiagnosed and may in fact be on the spectrum. One of the main problems is many diagnosticians do not recognize female ASD traits, and some flat out refuse to diagnose women. There is a bit of sexism built into the profession, and they are only now addressing it.

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16 Dec 2010, 3:23 pm

I'm definitely no expert on this but the muscle thing makes sense since mitochondrial DNA is in the muscles. Isn't their proof that mitochondrial DNA comes from your mother & this is how it was discovered that all humans are eventually interrelated (I read this in National Geographic years ago)? The only thing I'd buy is maybe an individual gene within the mitochondria may come into play or... maybe some OTHER gene(s) and its still GENETIC :roll: . To the point about humans evolving and the "herding instincts" not being as necessary... wouldn't it be less crazy for us to say we're the crappy version of X-Men (humans mutating :wink: ) than some of the autism cause theories out there?

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Peko
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16 Dec 2010, 3:27 pm

wavefreak58 wrote:

Zur-Darkstar wrote:

MidlifeAspie wrote:

jamesongerbil wrote:

That's odd that it was said to be a Mitochondrial disorder, but not genetic. After all, the mitchondria houses RNA, which happens to be transferred from the mother.

This was the same thought I had as well. If the cause is the DNA in the mitochondria of the mother, then all children, male and female, should be equally affected.

Males also tend to get X-chromosome linked genes such as those for hemophilia from their mothers. Girls can be carriers or in order to explain ASD's in girls have a Mom whose a carrier (got gene from her mom but spared disease due 2 2nd X-chrome) plus a dad w/ the gene or a mom with AS plus a dad w/ the genes, etc. Mitochondrial DNA may explain the gender gap in ASD expression.

wavefreak58
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16 Dec 2010, 3:34 pm

DandelionFireworks wrote:

If you are referring to my post, something can be a necessary condition without also being a sufficient one.

For example, if you need to reach something that is ten feet over your head and you have two boxes 2 feet tall, stacking the boxes one on top of the other will work. The first box in the stack is NECESSARY because you can't put the second box on the stack without the first already being there. But the first box is not sufficient because you need BOTH boxes to be able to reach the thing ten feet over head.

Hence faulty mitochondrial DNA may be necessary for autism, but not sufficient. Other things may have to be added to the stack, so to speak. So you could still be given the root cause of autism by your mother via MDNA, but the most common trigger is on the Y chromosome, hence more males with autism than females.

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16 Dec 2010, 3:34 pm

wavefreak58 wrote:

Besides, this guy is late to the party.

ALL the answers are here:

NewAutismCure.com

:roll:

I want to say a bunch of swear words & perversities to communicate how much I <3 and will keep my freakin' chocolate...

DandelionFireworks
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16 Dec 2010, 3:39 pm

wavefreak58 wrote:

DandelionFireworks wrote:

So, with me being female, do you think there's any chance it would be a cure? Because that's an unacceptable risk to me.

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DandelionFireworks
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16 Dec 2010, 3:40 pm

wavefreak58 wrote:

DandelionFireworks wrote:

So, with me being female, do you think there's any chance it would be a cure? Because that's an unacceptable risk to me.

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Janissy
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16 Dec 2010, 4:02 pm

DandelionFireworks wrote:

wavefreak58 wrote:

DandelionFireworks wrote:

I don't think there's much of a risk. The doctor's claims of "cure" are just the usual biomed stuff to "repair mitochondrial dysfunction" (his claim). The GFCF diet, removing toxins from your enviroment. That sort of stuff. I think you could safely dabble in GFCF diet if you wanted to see what would happen and then just discontinue it if it started feeling like a bad idea. The kid in the video who is "cured" seems rather like my daughter (for his 3 minutes of fame) so I wouldn't be surprised if he is actually still just as autistic as she is, just more talktative. I think some of these doctors (and then by extension the parents) confuse "autistic" with "non-verbal" and declare a child who learns to speak to no longer be autistic. I guess in order to hold onto that belief ("my son/patient is no longer autistic because he speaks") you also need to declare Aspergers to not really be autism. And there was a video about that too, in another thread.

So, with me being female, do you think there's any chance it would be a cure? Because that's an unacceptable risk to me.

edited to add: I really messed up the quotes here. Suffice it say that Janissy (me) is the one saying the 'cure' is all a bit of biomed nonsense.

Last edited by Janissy on 16 Dec 2010, 4:04 pm, edited 1 time in total.

wavefreak58
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16 Dec 2010, 4:03 pm

DandelionFireworks wrote:

So, with me being female, do you think there's any chance it would be a cure? Because that's an unacceptable risk to me.

Since I am not a scientist, I can't say much more about this MDNA thing other than its conclusions raise more questions than it answers.

I suspect that even if it turns out that there is a way through genetic engineering to splice in good genes, it will not cure an adult since the brain has already developed it major structures. An infant or an in utero fetus might benefit from gene splicing since the brain would then have a chance to develop along normal pathways.

This is where I scoff at the idea of a cure for adults on the spectrum. If autism is indeed structural, those differences can only be changed by surgery or some other method that restructures the brain on a physical level. Medication will only help symptoms.

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starygrrl
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16 Dec 2010, 4:49 pm

MidlifeAspie wrote:

DevilInside wrote:

Why do desperate parents cling on to any crackpot theory out there when there is plenty of REAL science to be found ?

Bucket = $5.00
Cake Funnel = $3.00
I cured my kid of autism for $8.00.

Plus, certain types of people will believe anything they read on the internet. They don't understand the concept of sourcing your data.

This. NT parents who believe in these crackpot theories don't necessarily understand scietific studies (or science). They are more likely to believe to their other NT parents, than to scrutinize studies. In other words, this is part of the issue with certian NTs, they may be good at socializing, but they are terrible at logical reasoning or scientific scrutiny.

AriNecromare1213
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16 Dec 2010, 5:10 pm

MidlifeAspie wrote:

I'm not sure which theory you are referring to above, it might be one I am not familiar with, but the "gut brain theory" I was referring to was where parents have come to believe that the bacteria in their child's colon is not the right type and this causes autism. So, all the "healthy" family members defecate in a bucket for a week. stir it all up, scoop it into a cake frosting tube and empty it into their child's rectum like an enema, thus "curing" their child of autism.

wow...I kinda have to laugh. Who said this? Someone actually believed this?

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MidlifeAspie
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16 Dec 2010, 5:12 pm

AriNecromare1213 wrote:

MidlifeAspie wrote:

wow...I kinda have to laugh. Who said this? Someone actually believed this?

Fecal Transplants - read it here:

http://leftbrainrightbrain.co.uk/2010/1 ... ransplant/

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