OK, if Caulfield from "Frazz" is an Aspie even though he doesn't have social skills issues as far as I can see (except with that teacher that no one really likes that well anyway; not all bright NT kids have perfect behavior in school), then there are a lot of other, much-more Aspie-seeming syndicated comic strip characters than him.
Huey from "The Boondocks": Nerdy, very intelligent, not much sense of humor for "normal" or "NT" type jokes, only has one friend, blatantly rude to people he considers stupid (not that some of them probably don't deserve it). Talks mainly about one or two topics.
Gunther from "Luann": Geeky, socially awkward, especially with girls, highly intelligent, dresses "nerdy", but still a very sweet, caring boy who usually gets his heart broken. If I remember correctly there have been social games going on around him which he has had problems understanding or picking up on. Also Luann's brother Brad: Only has one friend, not that great with girls, kind of easily led by his friend T.J. into things that he finds questionable morally. The only thing with him is, he's maybe not intelligent enough.
Jason from "Foxtrot": Geeky/nerdy, highly intelligent, only one friend, always seems to be at odds with his family members (one time at Christmas I particularly remember they were all mad at him).
Stick from "Pre-Teena": The kids pick on her (I thought it was for her looks, but could be her actions as well); a couple times it seems like she's taken things Teena or someone else said literally; seemingly made fun of Teena's Lithuanian grandma who couldn't speak English very well to her face by taking her saying "Kow are you" as if the grandma was asking what kind of cow she was, instead of how she was. (This could have been her being a deliberate smart-@$$, but she seems like a nice kid who wouldn't make fun of her best friend's grandma's poor English..I'm not sure what the writer was trying to imply here.)
Also occasionally I've read a strip called "Agnes" where the main character seems kind of Aspie, but I haven't seen it enough to know for sure...has anyone else seen this strip?
If not doing well socially qualifies, than what about "Monty", even though he doesn't seem intelligent enough. His best friend is someone from outer space, after all.
I suppose Rob from "Get Fuzzy" and Jon from "Garfield" could be Aspie too as their only friends seem to be their animals and they don't date much if ever. Jon is particularly bad about what he thinks women would like vs. the reality.
Some people see Gordon in "For Better or for Worse" as an Aspie, but I'm not sure why. I guess because he wasn't good with girls in high school and had a huge crush on one particularly unattainable girl. If anyone has any insight on this character and why he could be AS, please let me know. He has become very successful in business after not going to college, but not sure that makes someone an Aspie. Since this particular comic strip ages the characters and has followed 3 kids and their friends thoughout school (and the 2 oldest into their early adult lives), it seems like all of them have had friendship or relationship issues at some point, as does everyone usually, AS or NT.