My craziest idea yet: female hormone supplements

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Dunno, I have low testosterone and mildly high estrogen and have ASD. HOwever when I do take testosterone gel I get mentally worse and on edge....

But I still think its largely due to like high dopamine levels or soemthing like that. Maybe Testosterone interacts with it somehow

I'm an aspie male and I've always felt like I have a somewhat feminine mind, I agree.

when my testosterone levels were higher, i felt more alive.

Ive wondered about this too. I wonder what would happen to me with a combo of estrogen + oxytocin therapy?

Estrogen isn't going to treat or cure anyone's autism.

I have heard some interesting things about oxytocin, however. One woman on aspies for freedom described being treated with oxytocin as "being temporarily NT" if I recall correctly.

Nice terminology there Rascal

Back to the topic, less females being diagnosed with autism doesn't mean there actually are less females with autism. It's just that the clinical community is lagging behind in recognising it.

http://www.autism.org.uk/about-autism/a ... ctrum.aspx

http://www.autism.org.uk/about-autism/a ... op-it.aspx



http://www.nytimes.com/2007/08/05/magaz ... d=all&_r=0



(this one is a very interesting article overall too, and actually the evidence states the females are affected worse by autism than males)

I'm laughing so hard to myself.

Transwoman here, whom got WORSE after transition.
And I know I'm not the only one.

No, take testosterone boosters, and don't care at all you have ASD. Problem solved.

I'm female and since I started taking the progesterone-only mini-Pill over the last few months I've felt a lot better so it's definitely helped me.

All the hormones are linked so low quantities of one will have a knock-on effect on the production of others.

Wow, what a TERRIBLE idea. There's already evidence that males are getting way too much estrogen already, simply because it's in the water supply thanks to birth control, and it's actually causing some males to be born sterile. We are already way over feminized. The last thing we need is to be taking female hormones... Are you insane?

Citation needed. I've researched this several times and it seems about as credible as vaccines causing autism.

https://gene.sfari.org/GeneDetail/CYP11B1

"Genetic association has been found between the CYP11B1 gene and both autism and Asperger syndrome (Chakrabarti et al., 2009).

This gene encodes a member of the cytochrome P450 superfamily of enzymes participating in the conversion of progesterone to cortisol in the adrenal cortex."

https://imfar.confex.com/imfar/2009/web ... r5033.html

Background:
Although epidemiologists and toxicologists have started to investigate several chemicals as potential autism risk factors, it is still unclear what chemicals should be studied in this regard. A more objective and comprehensive approach to screening and prioritizing chemicals would be useful in designing future studies. This work should be informed by the most recent findings in the genetics of autism.
Objectives:
This analysis was an effort to find and demonstrate a way to cast a relatively wide net to identify chemicals that might merit further investigation as potential risk factors in autism, drawing upon the full range of genetic findings and a wide range of literature on gene-chemical interactions.
Methods:
The Comparative Toxicogenomics Database (CTD, http://ctd.mdibl.org) and AutDB (http://www.mindspec.org) were selected as relatively comprehensive, powerful tools for this type of analysis. The AutDB was used to identify 142 genes (as of late 2008) studied in autism, of which 122 genes were found to have reported chemical interaction data in the CTD. These interactions often consist of observed changes in gene expression in rodents exposed to various levels of the studied chemical substance. The chemical-gene interactions, GO terms, and pathways associated with these genes in the CTD were analyzed, and chemicals were manually classified as xenobiotics, medications, nutrients, and endogenous substances. Chemicals were prioritized based on number of reported interactions.
Results:
The genes MET, PTEN, ADRB2, and TH each had more than 30 interacting chemicals identified in the CTD, and 120 chemicals were reported to interact with PON1. Other genes, such as MECP2, TSC2, RELN, UBE3A, and GABRB3, showed interaction reports for only 4-14 chemicals each in the CTD. For many genes, such as EN2, SHANK3, FMR1, NLGN3, and NRXN1, the CTD contains interaction reports for only 1-2 chemicals so far.
Over 600 chemical substances were identified as interacting with any of the 122 autism candidate genes, of which 498 had unique CAS numbers.
Xenobiotics (or closely related substances) identified as interacting with autism candidate genes included the following (# of genes in parentheses): Carbon Tetrachloride (33), tert-Butylhydroperoxide (19), sodium arsenite (17), Lipopolysaccharides (11), Paraquat (10), nickel sulfate (9), Hydrogen Peroxide (9), arsenic trioxide (8), Benzene (7), Benzo(a)pyrene (7), Ethanol (7), Tobacco Smoke Pollution (4), Arsenic (4), Chlorpyrifos (4), Tetrachlorodibenzodioxin (4), and bisphenol A (4). Other chemicals previously implicated in autism or related conditions are also identified by this analysis, such as mercury compounds, lead, cocaine, fipronil, endosulfan, and phthalates.
Top substances related to dietary nutrients: Pirinixic acid (27 genes), Zinc, Resveratrol, Flavonoids, and Dietary Fats.
Top medications: Acetaminophen (49 genes), Tamoxifen, Diethylstilbestrol, Valproic Acid, and Celecoxib.
Top endogenous (or closely related) substances interacting with numerous autism candidate genes: Progesterone (37 genes), Estradiol, Ethinyl Estradiol, Corticosterone, and Thyroxine.
Conclusions:
As bioinformatics databases grow, they can inform prioritization of candidate environmental risk factors.

Thank you for that study - I was unaware of it, but it is interesting. I think I was misunderstood, however:

DerStadtShutz seemed to be talking about the notion that environmental estrogen (caused by birth control pill usage, etc) is feminizing men and causing sterility. I asked for a citation of this particular claim, and compared it to the notion that vaccines cause autism, which has not been validated to my knowledge.

I forgot to mention, it's also due to all the f*****g plastic water bottles we keep throwing into the trash day in and day out. They're made of a plastic that breaks down into estrogen and/or other female hormones, and they've been studying this. They've found that it makes people sterile, makes them produce less sperm, and causes the distance between the testicles and the anus to become shorter(i'm not sure exactly what the significance of this last one is, but I know there's a lot less space between a female's genitals and her anus than a male's).

Could you please link something that discusses this? I have not been able to find anything outside of conspiracy theorizing and panic-mongering on the topic.

Not according to the hyper-male brain hypothesis.