Hmm... weekends can be pretty tough, for the reason that I don't really know how they're going to plan out. During the week, I have more stability.
Of course, if I think of the weekend as a part of the greater routine of the week in general, then I usually adapt a bit better to it. The whole thing becomes a numbers game, where I know the weekend is coming up, and so I plan for the randomness a little more efficiently.
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"To have friends, a man need only be good natured, but when one has no enemies there must be something mean about him." -- The Prince, Oscar Wilde