Edenthiel wrote:
100000fireflies wrote:
Edenthiel wrote:
In my early 20's I had a bad bout of Lichen Planus. It reappeared a year ago when a medication I take ran into a shortage - and then disappeared once the medication was available again. Interestingly, a very positive side effect for me of the med is that with it my body was able to regulate serotonin for the first time since puberty. Years of papers out there on connections between serotonin regulation & autoimmune diseases...
If you don't mind saying, what was the med?
I've read a few studies with things i'd never expect (like milk thistle) providing benefit similar to ssris..i always find that interesting.
I'm on hrt (estradiol). Funny you mention milk thistle as it has fair levels of phytoestrogens (plant estrogen analogs). Estrogen influences the regulation of serotonin levels & re-uptake rates directly via specific receptors*. Serotonin, in turn has long been connected to immune & autoimmune response.
*Testosterone may do something similar, obviously using different receptors and mechanisms, but it appears to affect the levels of transport proteins for reusing serotonin rather than serotonin levels directly, if I understand correctly.
That is interesting. I didn't realize hrt could help that condition.
I have defintely read about estrogen and serotonin as well as progest and gaba..
I took estradiol for a while and it seemed to help neuro-wise at first, but then dwindled...i think it may still help a but, but it seems, when i get a rare, really good reaction to something, my brain auto-regulates to compensate and restore the original setting.
I didn't realize milk thistle was a known phytoestrogen, i usually only see the ones like soy listed. The study i referenced was actually on silymarin...i now wonder if perhaps that is the milk thistle constituent that is responsible for the phytoestrogen.
Interesting...to me

(this all is interesting to me..

) is that i use progesterone cream and i noticed that every end of the month when i'd double the quantity to emulate the natural cycle, my arthritis would flare. I then looked and began to find a few references/studies saying just that - that for what i have, progesterone can be a trigger /'make it worse. All of which...given progesterone's relation /dance with estrogen, estrogen having influence on serotonin...i haven't yet personally seen a lot with serotonin/autoimmune, but a relation there starts to make what i experienced make more sense...
As it was, i just saw progest - gaba, and thought if anything..stress/anxiety lower should = decreased symptoms.
I'll shut up now

. It's all quite amazing though! Thanks for your input on it...i now need to do some more research on the serotonin autoimmune relations!
_________________
"When does the human cost become too high for the building of a better machine?"