“Female Protective Effect” theory

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nick007
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05 May 2019, 4:09 pm

naturalplastic wrote:
This implies that autistic traits are all coded for on the X chromosome. Like hemophelia.

Females get two X chromosomes, while males get an X and a Y.

The Y is short and stubby, and therefore only has a fraction of the genes that its partner, the X chromosome has.

So if the X has a bad recessive gene there maybe nothing on the Y to overpower it. So a male child would get the effect of the recessive gene. In contrast every gene on a female's X is countered by another gene on the other, same length X, chromosome. The odds being that the corresponding partner gene would be the common version of the gene that would dominate and override the bad recessive gene. A female would have to be dealt two copies of the rare gene to get the condition - which would be far more unlikely than just getting one copy. Ergo the condition would be much rarer in females (much like in hemophelia).
I read this a couple times & I don't get it. If it's on the X chromosome & boys only get one whereas women get two, wouldn't autism occur much more in women than guys. My head hurts.


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Arganger
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05 May 2019, 9:58 pm

nick007 wrote:
naturalplastic wrote:
This implies that autistic traits are all coded for on the X chromosome. Like hemophelia.

Females get two X chromosomes, while males get an X and a Y.

The Y is short and stubby, and therefore only has a fraction of the genes that its partner, the X chromosome has.

So if the X has a bad recessive gene there maybe nothing on the Y to overpower it. So a male child would get the effect of the recessive gene. In contrast every gene on a female's X is countered by another gene on the other, same length X, chromosome. The odds being that the corresponding partner gene would be the common version of the gene that would dominate and override the bad recessive gene. A female would have to be dealt two copies of the rare gene to get the condition - which would be far more unlikely than just getting one copy. Ergo the condition would be much rarer in females (much like in hemophelia).
I read this a couple times & I don't get it. If it's on the X chromosome & boys only get one whereas women get two, wouldn't autism occur much more in women than guys. My head hurts.


It's not the same copy of X
You get XX and XY from your mom and dad.
Assume your dad has fxs, then lets say it's fXY and XX
You then get either fXY, or XY if you are male or
fXX or XX if female.
If fXY, you only have one copy of X and it happens to be an fX but if you are female you have two X and one of them is fX and the other X and the X can overpower the fX

Make sense?


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05 May 2019, 11:44 pm

Arganger wrote:
If I look at my own family, females and males with autistic traits is rather even.

In my family, autism seems to run on my dad's side. One of my dad's second cousins (male) was officially diagnosed, one of his first cousins (female) "seems autistic" (according to my family) but was never formally diagnosed, and then you have me (female). If that first cousin is for certain autistic (formally diagnosed), then you could say that more females than males in my family were diagnosed with autism. She doesn't really strike me as autistic, though.


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nick007
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06 May 2019, 3:34 am

Arganger wrote:
nick007 wrote:
naturalplastic wrote:
This implies that autistic traits are all coded for on the X chromosome. Like hemophelia.

Females get two X chromosomes, while males get an X and a Y.

The Y is short and stubby, and therefore only has a fraction of the genes that its partner, the X chromosome has.

So if the X has a bad recessive gene there maybe nothing on the Y to overpower it. So a male child would get the effect of the recessive gene. In contrast every gene on a female's X is countered by another gene on the other, same length X, chromosome. The odds being that the corresponding partner gene would be the common version of the gene that would dominate and override the bad recessive gene. A female would have to be dealt two copies of the rare gene to get the condition - which would be far more unlikely than just getting one copy. Ergo the condition would be much rarer in females (much like in hemophelia).
I read this a couple times & I don't get it. If it's on the X chromosome & boys only get one whereas women get two, wouldn't autism occur much more in women than guys. My head hurts.


It's not the same copy of X
You get XX and XY from your mom and dad.
Assume your dad has fxs, then lets say it's fXY and XX
You then get either fXY, or XY if you are male or
fXX or XX if female.
If fXY, you only have one copy of X and it happens to be an fX but if you are female you have two X and one of them is fX and the other X and the X can overpower the fX

Make sense?
I think I sorta get it now.


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magz
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06 May 2019, 4:45 am

Even if the prevalence of autistic minds is similar in males and females, there has to be some reason why the symptoms typically manifest more obviously in males.
It's a tricky question to disentangle all the social, genetic and other factors to find out.
I believe the answer is much more complex than simply X chromosome but there can be some contribution from it.


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traven
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06 May 2019, 6:00 am

Quote:
Even if the prevalence of autistic minds is similar in males and females, there has to be some reason why the symptoms typically manifest more obviously in males.


imagine it being more related to the bell curve, males being more visible on both the low and high end,
looks like autism that was also most visible in the extremes
thus possibly why it was noticed mostly there

Image
The more noteable difference is the higher standard deviation for men. Men are more spread out on the curve whereas women tend to cluster around the mean. This means more male geniuses, but also more males of lower intelligence.



magz
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06 May 2019, 6:08 am

^^ It would be interesting to learn the mechanism behind this phenomenon, too.


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