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Mikurotoro92
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12 Aug 2023, 12:58 am

Me and my brother are the ONLY ones in our family who are Autistic!

Our parents are NT

How is this possible?



madmick
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16 Aug 2023, 11:27 am

My mother said that her sister was odd. I didn't meet her as she had died. I am one of three and DX'd AS. My sister has three kids and one of them seems to have AS.



naturalplastic
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16 Aug 2023, 12:49 pm

uncommondenominator wrote:
Friendly reminder that there's a difference between "genetic" and "hereditary".

Hereditary means passed from ancestors to descendants via genes.

Genetic primarily means relating to genes, but does not inherently imply heredity.

While all inherited traits are genetic, not all genetic traits are inherited.

Genetic anomalies can and do occur, without it being a hereditary occurrence.

If you have autism, and so do a lot of other members of the family, it's probably inherited. However, if you have autism, and nobody else in your family has ever had it, for generations back, it's still genetic, since it's cos of how your genes turned out, but not necessarily hereditary, since it may not be from your ancestors genes, but rather from non hereditary factors messing with your genes.

Well...you can be a first generation 'mutant'. A gene got zapped when you were conceived so you get a genetic condition from the mutant gene ...that you did not get from anyone, but you could pass it on to your offspring.

Or more likely...with a condition like autism...there could be a dozen genes involved, and no one before you had the right combination of genes to get the condition until you got it, but you still inherited those genes from your parents and grandparents etc.

The later seems to be the case with me. Individual males on both sides of the family seem to have mildly aspie traits but no one but me seems to be full blown aspie. But aspergers and even autism have only been medically recognized for a couple of generations so its not even certain there could not have been relative who would be diagnosed on the spectrum fifty or a 100 years ago.



naturalplastic
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Ettina
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17 Aug 2023, 11:40 am

Jamesy wrote:
According to an alleged expert who works for the autistic society in the UK autism usually is inherited randomly. Basically if you get autism it has nothing to do with with other people in your family having the condition.

Do you think he’s right or not?


That's nonsense. If it's inherited, it's not random or unrelated to family history, by definition.

Was he saying it's usually a de novo mutation? It's possible for something to be genetic but not inherited. There are certainly plenty of people who are autistic due to de novo mutations - they make up the majority of cases of syndromal autism (autism that's a feature of a condition with multiple other features). For example, 50% of people with 22q13 deletion are autistic, and that condition is usually de novo, though it can be inherited. AFAIK no one with 22q13 deletion has reproduced (severe intellectual disability makes it much less likely) but if they did, their kid would theoretically have a 50% chance of the same condition.

However, most non-syndromal autism is inherited. While a few single gene mutations can cause autism without other symptoms (eg certain MECP2 mutations), most cases result from the interaction of many genes, and the probability of randomly getting a hundred different autism-related mutations de novo is so vanishly low that it's virtually impossible. In most cases, autistic kids have BAP parents and a bunch of extended family who are BAP or autistic.