Breaking News on Autism

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feelgoodlost
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10 Jan 2008, 12:20 am

Beau, did you go to Arizona State? You look really familiar

beau99
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10 Jan 2008, 12:24 am

feelgoodlost wrote:

Beau, did you go to Arizona State? You look really familiar

LOL...

no, not the last time I checked...

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psychotic
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10 Jan 2008, 5:27 am

wow thats certainly breaking news. also did you hear that some kid stole some chewing gum from Wal mart? he put it in his back pocket.

TLPG
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10 Jan 2008, 6:16 am

JerryHatake wrote:

Sedaka wrote:

alex wrote:

The fact that the chromosome abnormality exists in people with autism doesn't necessarily indicate causality.

yep... correlation does not equal causation.

Totally agree with you two.

Make that three!

The truth is, this is the start of a positive process. Skimming the link (the one v001 gave) over the first few pages, it looks like the chromosome identified may have multiple properties and this study only caught one of them. This may mean that the secret may lie in looking at the other properties and 0.6% that stands at the moment could go up.

Then again - it may not need to - given that the 4 in 712 is equivalent to 1 in 178, which is very close to the 1 in 150 stat that the community knows about at the moment. After all - it is statistically possible that 28 out of 150 DX's could be wrong!

Sedaka
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10 Jan 2008, 8:50 am

beau99 wrote:

feelgoodlost wrote:

I know this has been discussed, but I'm still unclear...when they say 1 in 150 have autism, are they talking LFA or LFA/HFA/AS?

The entire spectrum.

Meaning those with PDD-NOS are also included.

not that they specify it as such to the general public... i used to thin all autism was like rainman.

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Sedaka
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10 Jan 2008, 8:52 am

SirLogiC wrote:

It could be that there are many genes involved with ASD's. Perhaps all concerning brain development in some way. They still don't know what a lot/most of our genes do at this point. It could be one gene or it could be 20. Then perhaps some of them lay dormant unless you have a benign gene (like blond hair or a longer big toe), perhaps they only change the brain with environmental factors, thus some with the gene may never develop an ASD and another get it very bad.

This interplay of factors can get ever more complex. That they found a (possibly) definite link at all is certainly something to look at. However if they do find a cure I have to wonder is it worth curing high functioning ASDs? Sure a madly autistic person basically needs care all their life and can rarely contribute to society. Even some beneficial help that will allow them to communicate and interact better would be great. However what would the science field be like if there werent say people with AS there? No Microsoft Windows? Sure you may not like it but almost everyone has it, it works.

yep and what if it's the factors that regulate gene EXPRESSION and not the gene itself... so if the expression is messed up, the gene could be normal or mutated and you still get the same effect. maybe that's why they see so few of these mutations.

i think there's much more to the story than just mutations... per se

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zendell
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10 Jan 2008, 11:18 am

TLPG wrote:

JerryHatake wrote:

Sedaka wrote:

alex wrote:

The fact that the chromosome abnormality exists in people with autism doesn't necessarily indicate causality.

yep... correlation does not equal causation.

Totally agree with you two.

I think it's 1 in 178 people diagnosed with autism. Since 1 in 150 are autistics, it would be 1 in 26,250 people.

zendell
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10 Jan 2008, 11:19 am

psychotic wrote:

wow thats certainly breaking news. also did you hear that some kid stole some chewing gum from Wal mart? he put it in his back pocket.

You look awesome psychotic. I wish my face looked like that.

JerryHatake
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10 Jan 2008, 12:01 pm

zendell wrote:

TLPG wrote:

JerryHatake wrote:

Sedaka wrote:

alex wrote:

The fact that the chromosome abnormality exists in people with autism doesn't necessarily indicate causality.

yep... correlation does not equal causation.

Totally agree with you two.

I think it's 1 in 178 people diagnosed with autism. Since 1 in 150 are autistics, it would be 1 in 26,250 people.

I think the number is 1 in 120 are born with Autism which equals an increase in autism birth plus diagnosed.

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anbuend
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10 Jan 2008, 12:16 pm

TLPG wrote:

JerryHatake wrote:

Sedaka wrote:

alex wrote:

The fact that the chromosome abnormality exists in people with autism doesn't necessarily indicate causality.

yep... correlation does not equal causation.

Totally agree with you two.

Yeah. And there are more things that can happen to a chromosome besides deletion. (I know this from knowing a bunch of people with a lot of different MECP2 mutations, which can also cause autism and/or Rett's syndrome, and they now know there are milder versions of Rett's than before.) Often different forms of mutation can cause slightly different (or even greatly different) outward effects.

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Zarathustra
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10 Jan 2008, 12:30 pm

feelgoodlost wrote:

I know this has been discussed, but I'm still unclear...when they say 1 in 150 have autism, are they talking LFA or LFA/HFA/AS?

Figures from the UK National Autistic Society [ www.autism.org.uk ] LFA 5 per 10 000, HFA [inc AS] 70 per 10 000. Other statistics are available... ...

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zendell
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10 Jan 2008, 12:37 pm

feelgoodlost wrote:

I know this has been discussed, but I'm still unclear...when they say 1 in 150 have autism, are they talking LFA or LFA/HFA/AS?

"CDC’s Autism and Developmental Disabilities Monitoring (ADDM) Network released data in 2007 that found about 1 in 150 8-year-old children in multiple areas of the United States had an ASD."

"ASDs include autistic disorder, pervasive developmental disorder - not otherwise specified (PDD-NOS, including atypical autism), and Asperger syndrome."

http://www.cdc.gov/ncbddd/autism/overview.htm

Notes: The study released in 2007 was conducted in 2002. It looked at ASDs in 8 year olds. The rate of 1 in 150 is for children in the US who were born in 1994. The rates vary greatly in different locations and are higher among boys.

"ASD prevalence among eight-year-old children was 3.3 per 1,000 (Alabama) to 10.6 per 1,000 (New Jersey)." That's 1 in 303 in Alabama and 1 in 94 in New Jersey.

"ASD prevalence was higher among boys than among girls, ranging from more than three to more than six boys for every girl with ASD.

* Boys: 5.0 per 1,000 (Alabama) to 16.8 per 1,000 (New Jersey)
* Girls: 1.4 per 1,000 (Alabama) to 4.0 per 1,000 (New Jersey)"

Among girls in Alabama, the rate is 1 in 714.
Among boys in New Jersey, the rate is 1 in 60.

http://www.cdc.gov/od/oc/media/pressrel ... 070208.htm

LeKiwi
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10 Jan 2008, 2:32 pm

That seems a bit of an over-reaction... but then 'them' journalists just looove sensationalist headlines (I say 'them' as I'm a journalist too, but I prefer to put real news out there, not misleading the population again and again. Don't get me started on how much I hate tabloid-style journalism).

I'm still sure there must be a number of causes of autism/ASDs. Bear in mind it's a syndrome too - ie a group of 'symptoms' that a number of people exhibit - so there could be several things that lead to those same 'symptoms' developing and a diagnosis of ASD. Hence why I refuse to discount vaccines and medicines as a potential cause, alongside something in the environment, and - without any doubt - genetics.

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TLPG
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10 Jan 2008, 4:20 pm

zendell wrote:

TLPG wrote:

JerryHatake wrote:

Sedaka wrote:

alex wrote:

The fact that the chromosome abnormality exists in people with autism doesn't necessarily indicate causality.

yep... correlation does not equal causation.

Totally agree with you two.

I think it's 1 in 178 people diagnosed with autism. Since 1 in 150 are autistics, it would be 1 in 26,250 people.

Would you mind explaining that mathematical conclusion? Since when did 1 in 150 suddenly equal 1 in 26,250?

TLPG
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10 Jan 2008, 4:23 pm

LeKiwi wrote:

I'm still sure there must be a number of causes of autism/ASDs. Bear in mind it's a syndrome too - ie a group of 'symptoms' that a number of people exhibit - so there could be several things that lead to those same 'symptoms' developing and a diagnosis of ASD. Hence why I refuse to discount vaccines and medicines as a potential cause, alongside something in the environment, and - without any doubt - genetics.

You'd better discount the vaccines, LeKiwi, because when this study bears fruit - those who were damaged by vaccines (and they do exist) will lose their ASD DX. There aren't many of them though compared to the correctly DXed ASD people. Like I said - 28 seems a fair number out of 178.

LeKiwi
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10 Jan 2008, 4:35 pm

They shouldn't though; ASDs are part of a syndrome... a group of 'symptoms' a group of people have in common. That doesn't necessarily mean there can be just one cause; there could be any number that lead to the exhibition of the syndrome.

Hence why - although I do believe genetics to be the primary 'culprit' - I also believe vaccines/certain medicines, environmental factors, etc could play a big part in its development.

Just because one cause (one we all knew anyway) is found doesn't mean others shouldn't be investigated or hold credence too...

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