If anime counts then... Haruhi Suzumiya. Also, I can't help but feel like Chuckie Finster is autistic. I mean, he has the anxiety and odd phobias down packed for starters. He's also not the most social one of the bunch other than having Tommy and the others either. I've also noticed he isn't big on change, especially with the episode where he was trying to potty train. It took him a while to adjust to the very idea of it. I haven't seen Rugrats or All Grown Up in a very long time though.
I do relate to Chuckie a lot in terms of anxiety though.
Haruhi Suzumiya strikes me as having AS. Why? For starters, she's not big on social interaction. She doesn't understand what having 'friends' really means, even though she has Kyon, Yuki, Mikuru and Itsuki. She also has very narrow interests and seems to be into the abnormal stuff rather than what's considered everyday situations. She once dated a bunch of guys for like a day, and eventually told them she doesn't have time for any of it. She's also the bossy type and gets a kick out of ordering Kyon around.
I also think that if Yuki wasn't an alien, she'd also have AS. She's anti-social. Her only interest she has is reading any book she can, and she has a very flat, monotone voice. She's also someone I find to be very introverted as well.
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Currently diagnosed with Autistic Disorder, ADHD, severe anxiety, learning delays and developmental delays.