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zendell
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10 Jan 2008, 8:22 pm

TLPG wrote:
zendell wrote:
TLPG wrote:
given that the 4 in 712 is equivalent to 1 in 178, which is very close to the 1 in 150 stat that the community knows about at the moment. After all - it is statistically possible that 28 out of 150 DX's could be wrong!


I think it's 1 in 178 people diagnosed with autism. Since 1 in 150 are autistics, it would be 1 in 26,250 people.


Would you mind explaining that mathematical conclusion? Since when did 1 in 150 suddenly equal 1 in 26,250? :?


You would be correct if the study found the genetic "microdeletion" in 1 in 178 of the general population and it caused autism in every case.

However, the study found it in 1 out of 178 people with autism who have this genetic problem. They examined 837 controls and none of them it.

Without autism - 0 out of 837 (0%)
With autism - 4 out of 712 (0.6% or 1 in 178)
The other 99.4% of autistics do NOT have this genetic problem

Since it was only found in autistics and only 1 in 150 have an ASD, the rate in the general population is 1/178 * 1/150 = 1/26,250.

Quote:
this genetic "microdeletion" occurred in only four out of 712 subjects with autism (0.6%)

To find genes linked to autism, the researchers scanned the entire genomes of 180 subjects with autism searching for submicroscopic pieces of DNA that were either lost or mistakenly duplicated in patients diagnosed with autism. They first found that two out of those 180 (1.1%) had a deletion in region 16p11.2, on the short arm of chromosome 16. None of the 372 control subjects had the same deletion.

To confirm that result, the researchers screened DNA from an additional 532 subjects with autism. They found two additional subjects with the same deletion (0.4%), which was seen in none of the 465 controls. Combining the two samples produced a total prevalence of 16p11.2 deletions of 0.6 percent.



TLPG
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11 Jan 2008, 4:42 am

OK Zendell, now you've really annoyed me.

Not the maths calculation. I'm referring to the fact that this study only looked at ONE ANGLE of the 16th chromosome. You assume that it proves that Autism is only 1 in 26,000. It does no such thing. Once the other angles are looked at - that 0.6% will likely go up. The 1 in 178 and 1 in 150 is a pleasant coincidence and nothing more.

LeKiwi, once the diagnostics are properly determined (hopefully by the DSM-V but that's not likely) - those damaged by vaccines will be indentified as such. Damaged people do NOT equal "syndrome". A syndrome is a genetic condition, and it always will be. Take away the genetic factor, and it ceases to be a syndrome. It becomes a disease or another medical condition that can be cured. Once we have a root genetic issue, anyone without that issue will not be DXed on the Autistic Spectrum. The symptoms will cease to matter - as they shouldn't under such circumstances.



autism_diva
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11 Jan 2008, 5:14 am

BertBlyleven wrote:
im eagerly anticipating a response here from the pharmaceutical compa....err....beau and autismdiva


Not funny, actually.


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autism_diva
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11 Jan 2008, 5:24 am

TLPG wrote:
OK Zendell, now you've really annoyed me.

Not the maths calculation. I'm referring to the fact that this study only looked at ONE ANGLE of the 16th chromosome. You assume that it proves that Autism is only 1 in 26,000. It does no such thing. Once the other angles are looked at - that 0.6% will likely go up. The 1 in 178 and 1 in 150 is a pleasant coincidence and nothing more.

LeKiwi, once the diagnostics are properly determined (hopefully by the DSM-V but that's not likely) - those damaged by vaccines will be indentified as such. Damaged people do NOT equal "syndrome". A syndrome is a genetic condition, and it always will be. Take away the genetic factor, and it ceases to be a syndrome. It becomes a disease or another medical condition that can be cured. Once we have a root genetic issue, anyone without that issue will not be DXed on the Autistic Spectrum. The symptoms will cease to matter - as they shouldn't under such circumstances.


But there is no evidence in the least that vaccines can cause anything that looks even a little like autism, unless you think MR/ or random "brain damage" looks like autism.

Autism and ASDs are pretty specific. "Brain damage" is not specific. We know what some of the brain structures are that are tend to be found in autism. These are not found in random "brain damage".

There is just no reason to link vaccines and autism. None at all. What there are are a bunch of parents who are looking for someone to sue, and some who heard that vaccines cause autism and just believe that since their kid is autistic and their kid was vaccinated then the vaccines must have done it.

If you can draw a line between vaccines and autistic behaviors you'll be doing what none of the lawyers could do in the Omnibus so far and they have all the scientists who have allied themselves with the DAN! quacks to speak for them in court. It's all bunk. It's tissue paper thin. The autism/ vaccine thing is a pack of lies and hysteria.


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DeaconBlues
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11 Jan 2008, 11:47 am

For those arguing about the math - the deletion of 16p11.2 was found in 1% of autistics. It was not cited as "the cause" of autism - it was merely noted that it was found in 1% of autistics, 0.1% of those with schizophrenia or language disorders (and why those two were grouped together is a debate for another time), and none of the control group. And this was when they were able to ring in the Icelandic data, with a survey of over 18,000 people. (Oops, I forgot - Iceland is in the pocket of Big Pharma, the group so big and bad they scare the Mafia, aren't they? My bad!)

Implication is that 16p11.2 may be involved in language processing. Has nothing, however, to do with mirror neurons, sensory issues, growth of the amygdala or hypothalamus, or any of the other neuroanatomical differences in autistics.


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zendell
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11 Jan 2008, 1:24 pm

TLPG wrote:
OK Zendell, now you've really annoyed me.

Not the maths calculation. I'm referring to the fact that this study only looked at ONE ANGLE of the 16th chromosome. You assume that it proves that Autism is only 1 in 26,000. It does no such thing. Once the other angles are looked at - that 0.6% will likely go up. The 1 in 178 and 1 in 150 is a pleasant coincidence and nothing more.


The 1 in 178 and 1 in 150 aren't related at all. The 1 in 26,000 is the number of people who have problems with that one angle of the 16th chromosome.

It looked like you meant 150 out of 178 (84%) have the problem with the 16th chromosome with the other 28 out of 178 being either misdiagnosed or explained by something else. That's why I pointed out that only 0.6% have the specific problem mentioned and the other 99.4% is unexplained. I'm sure they will look at other angles and the 0.6% will keep getting higher.



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11 Jan 2008, 4:55 pm

autism_diva wrote:
But there is no evidence in the least that vaccines can cause anything that looks even a little like autism, unless you think MR/ or random "brain damage" looks like autism.


To the untrained eye, Diva, it does. That's the problem with idiots like Generation Rescue and the mercury militia - they run with that faster than a drugged up Ben Johnson.

Which is why I said what I said to Le Kiwi - brain damage doesn't equal syndrome and hopefully the DSM-V will make that difference much clearer. There are some brainless quacks out there - but of course we both know that!

Zendell - the connection between 1 in 178 and 1 in 150 is pleasant coincidence. But I'm pleased to see you agreed with the rest of it.



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11 Jan 2008, 7:11 pm

But the big question is, if it occured in four out of over seven hundred autistics, then why didn't it occur even once in over eight hundred without autism? What does this suggest?


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rossc
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20 Jan 2008, 4:00 am

autism_diva wrote:
TLPG wrote:
OK Zendell, now you've really annoyed me.

Not the maths calculation. I'm referring to the fact that this study only looked at ONE ANGLE of the 16th chromosome. You assume that it proves that Autism is only 1 in 26,000. It does no such thing. Once the other angles are looked at - that 0.6% will likely go up. The 1 in 178 and 1 in 150 is a pleasant coincidence and nothing more.

LeKiwi, once the diagnostics are properly determined (hopefully by the DSM-V but that's not likely) - those damaged by vaccines will be indentified as such. Damaged people do NOT equal "syndrome". A syndrome is a genetic condition, and it always will be. Take away the genetic factor, and it ceases to be a syndrome. It becomes a disease or another medical condition that can be cured. Once we have a root genetic issue, anyone without that issue will not be DXed on the Autistic Spectrum. The symptoms will cease to matter - as they shouldn't under such circumstances.


But there is no evidence in the least that vaccines can cause anything that looks even a little like autism, unless you think MR/ or random "brain damage" looks like autism.

Autism and ASDs are pretty specific. "Brain damage" is not specific. We know what some of the brain structures are that are tend to be found in autism. These are not found in random "brain damage".

There is just no reason to link vaccines and autism. None at all. What there are are a bunch of parents who are looking for someone to sue, and some who heard that vaccines cause autism and just believe that since their kid is autistic and their kid was vaccinated then the vaccines must have done it.

If you can draw a line between vaccines and autistic behaviors you'll be doing what none of the lawyers could do in the Omnibus so far and they have all the scientists who have allied themselves with the DAN! quacks to speak for them in court. It's all bunk. It's tissue paper thin. The autism/ vaccine thing is a pack of lies and hysteria.


What you an TLPG say in absolutes is not in fact absolutes. What people on the "other side" of the autism debates say in absolute terms is also not absolute.

Whilst these semantics are thrashed out you risk bogging down healthy debate.

My opinion I "believe" autism is genetic. I "believe" there is a genetic predisposition that when triggered in people born on the spectrum is responsible for the neuropathways in the brain developing differently. This leads to sensory, social and other problems due to this difference neurologically.

This is "just my belief" nothing more or less and I do not claim anything more. I accept that some stage I may be proven wrong and I have no issue.
What is FAR more important is the way to conduct myself in my real life and to help my boy grow into a happy and content man.
As a side consideration my loyalty to others with the conditions is to do my little bit to nature and support and share with others on the spectrum. I also to a lesser extend feel obliged to defend against problematic approaches to autism.