Revenant wrote:
Quote:
That's why you take an MAOI with it ie: Harmine/harmaline (tobacco, passion flower).
Monoamide Oxidase-Inhibitors are extremely dangerous to take with drugs that increase serotonin levels in the brain. Particulary psychedelics and amphetamines such as DMT, LSD, LSA, 5-Meo, MDMA and others. MAOIs inhibit destruction of serotonin. So the brain would be over-flooded with serotonin which cause desentisizing of receptors.
I think
www.dancesafe.net(If i remember correctly) had an animation of the brain under the influence of MDMA. You should check it out. It is relevant to all drugs that release serotonin in large amounts.
Now I know Ayahuasca brews contain MAOIS as well as other interesting psychoactives. When I was a tripper, I always wanted to try Ayahuasca after seeing the movie "Blueberry"(If I remember the title correctly. I was kind of disabled mentally that time from all the drugs). It was about this cowboy dude who drank ayahuasca. There was a nice rendering of his psychaedelic experience.
I've forgotten the plot since this was over 2 years ago, and I was pretty sedated all the time back then.
The potential dangers of MAOI anti-depressants kept me away from them. There are a ton of dietary requirements (basically, avoiding foods with tyramine content - that is, fermented, aged, or overripe foods ie: cheese). Never take an MAOI drug with the SSRI anti-depressant type or MDMA, as this can lead to Serotonin Syndrome (as you say, the brain would be over-flooded with serotonin) causing various adverse effects, even death.
Reversible MAOI (such as harmala alkaloids) use is less cause for concern when combined with a tryptamine hallucinogen, but one should still be cautious of all seritonergic drugs, or drugs acting on 5HT2 receptor when combined with an MAOI. And never combine an MAOI with SSRI or amphetamine drug. As for tryptamine (psilocybin, DMT) be careful, know what foods to avoid "just in case", ensure the MAOI is reversible in effect (and short acting, 6-12 hours at most). Know the drug, dose, and so on. Basically, do your research; stay safe.
The url for Dancesafe is
Dancesafe.org.