Did anybody here become autistic after vaccinations?
I was just wondering if anybody here became autistic after they got the vaccinations, meaning you were very much an NT kid then all of a sudden changed into an Autistic kid? I find it soo weird that vaccinations are making some children autistic, and other children don't get affected at all. It doesn't make any sense. I was born with autism, its genetic, I'm pretty sure haha. I hated being held, would scream until you put me down, try to scratch your eyes out.
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mmaestro
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Correlation does not imply causation. Autism tends to first become obviously visible at around 18 months. Toddlers also get a big round of vaccinations at 18 months. Parents see the vaccines, their kids then become visibly autistic, and they draw the connection. But in fact there is no connection. Had the children not been vaccinated, they still have started to show symptoms of autism at the same time. The study that initially showed a link was fatally flawed, only one of the authors still endorses the study, and the journal that published it has disavowed the paper. Numerous other studies have shown that there is no link.
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Thats weird though, why are so many parents complaining about it, like I know a woman at the hospital I work with, met her kid, was a typical boy, nothing wrong, got the vaccinations and all of a sudden wouldn't talk, was drawn from the world. You can also see symptoms of autism before the age of 18months. I work with a baby whos 9months at the hospital, thats already showing symptoms of autism, when I asked the nurses, they said shes most likely autistic, because she pokes her eyes, stiffens up when tried be held, screams when shes touched, and cries all the time. When I was adopted I was the same way, at the age of 5 months, but I didn't cry, just scream, hated being held, never looked in persons' eyes, and would have a nasty temper. So thats why I asked that. I still think autism, is genetic and has to do with enviroment, but who knows!
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Yea I agree, Jenny McCarthy is funding so much money into research about autism linking to vaccinations as we speak. I still think its genetics haha..
well... once i know who or what is responsible, i will know who or what to sue
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I don't think we'll have an answer on the relationship between vaccinations and autism for a while. Or an answer on the genetics.
My take is that autism is a developmental disorder - something blocks the 'normal' or typical development of the nervous system. It seems that there is an autoimmune component of autism. It is not clear if that autoimmune destruction of some nerve cells is the driving factor of autism - maybe.
That change in the way the body develops can occur at various times - it could occur before birth or after. Which may or may not be genetic, or the result of a genetic predisposition.
For most autistic kids, the initial differences are subtle enough that it may not be recognized initially. Kids naturally hit certain phases of development at certain ages. And most commonly, the differences become apparent after a kid reaches an age where they have gotten some vaccines. So it is only natural that some parents link the deficit with various vaccines that were given around the time, or a few months before they notice the autism. That mental linkage does not mean that the vaccines did or did not cause the problem.
I personally don't think the mercury (thimerosal) in children's vaccines is the main factor that causes or triggers autism. But here is an interesting study that found that if the pertussis bacteria protein (used in the DPT vaccine) is given at the same time that egg protein is in the blood, the body will develop a persistent immune response to that egg protein.
Effects of pertussis toxin on delayed-type hypersensitivity responses and on the activity of suppressor T cells on the responses.
Tamura S, Nakanishi Y, Kojima A, Otokawa M, Uchida N, Sato H, Sato Y.
Experiments were performed on mice to investigate the effects of pertussis toxin (PT) on delayed-type hypersensitivity (DTH) to ovalbumin (OA) and on the activity of suppressor T cells on the DTH (DTH-Ts). Mice immunized with alum-precipitated ovalbumin showed a transient DTH, which was determined as footpad swelling which disappeared 2 weeks after immunization. Maximal footpad swelling was observed 24 hr after DTH elicitation. On the other hand, when mice received PT (2 micrograms/mouse) at the time of immunization, the transient DTH became an enhanced and persistent DTH, which persisted for at least 4 weeks. In addition, the time of maximum footpad swelling was delayed from 24 to 48 hr after DTH elicitation. The immune spleen T cells from PT-treated mice showed a persistently high ability to transfer DTH into syngenic naive mice. DTH-Ts was induced in spleens of mice injected iv with OA-coupled syngeneic spleen cells. However, when these mice received PT at the time of suppressor induction, their spleen cells revealed considerably reduced suppressor activity. The activity of DTH-Ts was also reduced when DTH-Ts were either treated in vitro with PT or transferred into PT-injected recipient mice. From these results, interference with the suppressor function of DTH-Ts from PT was considered to be, at least in part, as an enhancing mechanism of DTH.
PMID: 6315242
Imagine that a kid has some weakness in his digestive system that allows more undigested protein to enter the blood. If they get a pertussis vaccine (or a bacterial infection of some kind) when that food protein is in the blood, they can develop persistent antibodies to the food. These antibodies are not truly silver bullets, they can also attack some of the body's own proteins - nerve cells, heart muscles, etc.
In this hypothetical explanation of what might cause autism, the biggest factor may not be the vaccines - it is whatever causes the gut to allow too much protein into the blood. And genetics play into it, because people can have different immune reactions according to genetics. And diet, and natural exposure to bacteria and viruses and parasites also could play a role.
Brain-specific autoantibodies in the plasma of subjects with autistic spectrum disorder.
Cabanlit M, Wills S, Goines P, Ashwood P, Van de Water J.
Division of Rheumatology, Allergy and Clinical Immunology, UC Davis, Davis, CA 95616, USA.
Although autism spectrum disorder (ASD) is diagnosed on the basis of behavioral parameters, several studies have reported immune system abnormalities and suggest the possible role of autoimmunity in the pathogenesis of ASD. In this study we sought to assess the incidence of brain-specific autoantibodies in the plasma of children with autism (AU) compared to age-matched controls including, siblings without ASD, typically developing (TD) controls, and children with other developmental disabilities, but not autism (DD). Plasma from 172 individuals (AU, n = 63, median age: 43 months; TD controls, n = 63, median age: 48 months; siblings, n = 25, median age: 61 months; and DD controls, n = 21, median age: 38 months) was analyzed by Western blot for the presence of IgG antibodies against protein extracts from specific regions of the human adult brain including the hypothalamus and thalamus. The presence of a approximately 52 kDa MW band, in the plasma of subjects with AU, was detected with a significantly higher incidence when compared to plasma from TD controls (29% vs. 8%, P = 0.0027 and 30% vs. 11%, P = 0.01, in the thalamus and hypothalamus, respectively). Reactivity to three brain proteins (42-48 kDa MW), in particular in the hypothalamus, were observed with increased incidence in 37% of subjects with AU compared to 13% TD controls (P = 0.004). Multiple brain-specific autoantibodies are present at significantly higher frequency in children with AU. While the potential role of these autoantibodies in AU is currently unknown, their presence suggests a loss of self-tolerance to one or more neural antigens during early childhood.
PMID: 17804536
Yea I agree, Jenny McCarthy is funding so much money into research about autism linking to vaccinations as we speak. I still think its genetics haha..
well... once i know who or what is responsible, i will know who or what to sue
lol. To tell you the truth, I think its genetics, and the vaccinationss may cause the gene to now be more dominant, hence making the child autistic. Meaning the child had autism already but since it wasn't dominant, in the first place, he became NT. I don't think the vaccinations have to do anything with making the child autistic. It wouldn't make any sense because half the children don't get affected at all, and then the other half become autistic. I think most people are blaming the vaccinations, but I have a feeling autism has been around for a loong time, and just recently in the last 20 years or so, have been identified as a brain disorder. I bet you nobody even knew what was going on, so they assumed it was mental retardation, even if it seemed mild, so they were all put in mental hospitals. I only made this post to see if anybody did become autistic after the vaccinations.
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mmaestro
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The research has been done. It's proven. Vaccines have nothing to do with autism spectrum disorders, and perpetuating that myth is very dangerous from a public health perspective. There have already been outbreaks in London of diseases (notably mumps) which are normally vaccinated against in childhood because parents were afraid of vaccines causing autism. Children have died because of this myth. It's not true, and treating it with anything other than contempt is dangerous. If I sound angry, it's because I am.
Age1600, everyone's different - of course some are going to show symptoms outside of a certain age range, but that doesn't mean it isn't relatively common for the really visible symptoms to appear at around 18 months.
And I know, very indirectly, someone to whom the same thing happened. They were adament that vaccines had caused their child's autism, and so when they had a second son, they didn't have him vaccinated. 18 months came, and... there was a sudden onset of autistic symptoms, he became withdrawn from the world, and stopped talking. Exactly the same thing happened with both sons, one was vaccinated, one was not. Admittedly, this is an anecdote, but the point is that it's easy to draw conclusions from an individual case where timing is simply a coincidence.
Edit: It's tangendental, but there was a study out last week from Simon Baron-Cohen's group in Cambridge looking at prenatal hormone levels and autistic traits in non-autistic children, and they found a correlation with elevated testosterone levels in the womb. That, and genetic predisposition, are the big avenues of investigation right now.
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Last edited by mmaestro on 20 Sep 2007, 12:32 pm, edited 1 time in total.
No, the immune/autoimmune component of autism has not been disproven. In fact, the possibilty that there is some type of immune switch that gets flipped is very real, and supported by evidence. Vaccines cannot be said to be completely unrelated to autism - someday perhaps that will be the conclusion, but at this point, that is premature.
Yes, not getting vaccines has risk. So does getting them. There are a lot of unknowns about the true risk levels for vaccines.
Here is a recent study that found for 53 children with ASDs, mothers with an Rh negative blood type were 2.4 times more likely to give birth to a child that eventually showed some type of autism. Also interesting was the fact that all 53 mothers had taken a thimersol containing vaccine while pregnant to prevent them from having a possible immune reaction to blood from the child they were carrying. This does not prove that thimerosol or Rhod(D) globulin are the cause (maybe, maybe not). Combine it with the other research on autoantibodies to nerve protein that is found in high levels in ASD, and the immune system is clearly an arena to study.
A prospective study of thimerosal-containing Rho(D)-immune globulin administration as a risk factor for autistic disorders.
Geier DA, Geier MR.
The Institute of Chronic Illnesses, Silver Spring, MD, USA.
BACKGROUND: This study evaluated the relationship between prenatal mercury exposure from thimerosal (49.55% mercury by weight)-containing Rho(D)-immune globulins (TCRs) and autism spectrum disorders (ASDs). METHODS: The Institutional Review Board of the Institute for Chronic Illnesses approved the present study. A total of 53 consecutive non-Jewish Caucasian patients with ASDs (Diagnostic and statistical manual of mental disorders, fourth ed. - DSM IV) born between 1987 and 2001 who presented to the Genetic Centers of America for outpatient genetic/developmental evaluations were prospectively collected from June 1, 2005 through March 31, 2006. Imaging and laboratory testing were conducted on each patient to rule out other causal factors for their ASDs. As race-matched controls, the frequency of Rh negativity was determined from 926 non-Jewish Caucasian pregnant women who had presented for outpatient prenatal genetics care to the Genetic Centers of America between 1980 and 1989. RESULTS: Children with ASDs (28.30%) were significantly more likely (odds ratio 2.35, 95% confidence interval 1.17-4.52, p < 0.01) to have Rh-negative mothers than controls (14.36%). Each ASD patient's mother was determined to have been administered a TCR during her pregnancy. CONCLUSION: The results provide insights into the potential role prenatal mercury exposure may play in some children with ASDs.
PMID: 17674242 [PubMed - indexed for MEDLINE]
Last edited by monty on 20 Sep 2007, 12:35 pm, edited 1 time in total.
One study I read, which had a fairly large sample, studied vaccinations and regression. They didn't find a correlation between the two but did recognize this "regression". However, they found that the vast majority of children who regressed still had subtler autistic traits prior to regressing. They were just subtle enough to not raise any parental alarm bells.
On the subject of vaccination, I have been studying this a bit-- including the immunology of ASCs-- and believe there could be some connection between vaccination (be it the attenuated viruses or a heavy metal agent) which could be causally linked to an alteration in one's condition, increasing ASC traits. I still believe it is autism from birth, even if subtle. But it was well-known in the accepted literature that vaccinations have been linked to a triggering of autoimmune disorders. And if indeed there is an immune/autoimmune component to some peoples' autism, it makes sense than an environmental agent could affect the etiology.
The problem is I think too many parents are so desperate and illogically willing enough to blame EVERYTHING on a vaccine or a toxic agent. This I find no evidence for.
These larger studies-- which might I remind are carried out by the CDC, who has a vested interested in continuing childhood vaccinations-- seem to me poorly inconclusive because they are not looking for subtle variety and look simply for larger correlatives, which yield no results. They look for strict occurrence rather than by degree.
The studies which I've read still are small but many, so more research is needed. However, most agree there are abnormalities with the immune system and methylation pathways linked with ASC. Whether this is only for a portion of individuals or actually ends up being integral to the development of all ASCs, only time and good solid research will tell.
As for myself, personally, my mother noted a change in my personality following the DPT. At the time, in the media, there was a big scare linking the Pertussis vaccine to MR. Since then, that vaccine has had an "update" and is even more attenuated (weakened). However, I was always a strange infant/child and had inner ear infections and allergy since my early days. To me, if I did have an immune or oxidative reaction to any part of the DPT, it might've been something to effect the course of my development, but I was always autistic and meant to be. But I can't say for certain it had no effect. Though I suspect if it did, since my mother refused the second pertussis dose, it was little to none.
I used to deny any links between vaccination and ASC. But I got over that because I realized the only reason I thought that wasn't based on evidence but was because I didn't want there to be a link, implying that we are damaged and not truly meant to be autistic. But even though I now think vaccination could be one part of a larger picture, it doesn't make me feel I-- or any of us-- are damaged. Because we, as humans, do not grow up in vacuums, EVERY PART OF OUR PERSON is affected by our environment; it is a constant interaction of biology and environment and they are two sides of the same coin. So why couldn't a vaccine be a part of that? To me, this idea no longer makes me defensive.
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mmaestro
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Again, correlation does not imply causation. Were thermisol and other vaccinations to blame, you'd expect lower rates of autism in countries such as Sweden, which never allowed thermisol, and which have different vaccine regimens. You don't see a difference in the rate of autism. It's the same. Is there a connection between autism and these things entering the blood stream? Possibly. But that doesn't mean one doesn't cause the other.
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"You're never more alone than when you're alone in a crowd"
-Captain Sheridan, Babylon 5
Music of the Moment: Radiohead - In Rainbows
Yeah. I know about correlation and causation. But when a group of immune variables are collinear with autism, it should be grounds for more research. Until this correlation can be explained in some other way and the true causes of autism are laid out with the t's crossed and the i's dotted, you can't say that vaccines are not involved.
And I don't think it is so much the thimerosol. It could be that an immune switch is more likely to get flipped by bacterial or viral proteins in a vaccine regardless of whether it is denatured with thimerosol or some other way - heat, acid, whatever. It could be changes in hygeine/antibiotics or some other factor that leads to immune change that triggers autism in the susceptible. It could be changes in food production or the introduction of foods to infants combined with increased movement of food allergens into the blood.
If ASDs are anything like heart disease or psoriasis or other autoimmune disease, there are lots of things that can cause an increased risk. We can't explain heart disease by a single factor. It is about many dietary factors (saturated fat, fiber, sodium, folate, etc) , it is about smoking and other vices, it is about lack of exercise, it is about stress, it is about genetics (to a degree in most people, 100% in a few), it is about gingivitis and particulates in urban air and many other things.
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