Page 1 of 1 [ 12 posts ]
23 Oct 2010, 11:01 am
I'm writing about a current event (story has to be 6 months or less). and it has to be on ,Weight Loss, Healthy Weight, Nutrition, or Body Composition. A lightbulb went off the whole gluten/Autism debate. This falls under nutrition and if it helps with behavior issues (in this case those of Autism). I think this would be an interesting idea to use for a current event. If you guys can think of any Autism articles related to the above topics PM me or post a link in here please? Surely yall wouldn't mind helping me out a little please? Pretty please? BTW I already found 1 study but I was trying to think of other Autism topics related to those class topics. Let me know what you find. I'd appreciate the help. 
23 Oct 2010, 3:31 pm
24 Oct 2010, 5:58 am
Don't know if this is the sort of thing you're looking for, but here's a quote from my post in the thread "Special Diets" at: http://www.wrongplanet.net/postxf116431-0-15.html in the Parents Forum about such a study:
ouinon wrote:
A recent study ( publ. April 2010 ) found that a subset, 36.7% to be precise, ie. more than a third, of a significant sample of children diagnosed with autism have what has been called "leaky gut", compared to just 4.8% of the general population.
ie. more food opioid peptides, present in both gluten and casein, ( not just one of them ), are going to enter the bloodstream directly and reach the brain in that subset of people on the spectrum, ( more than a third of autists ), than in the general population.
Not only that, but that study and another one show that the gut/intestines are particularly leaky in the presence of gluten and casein, ( food opioid sources ), because of the effect that gluten has on the production of zonulin, which triggers intestinal cells to relax their "tight junctions" ( not sure about casein ).
This is quite a good article/blog piece on it by a psychiatrist:
http://evolutionarypsychiatry.blogspot. ... ism-1.html
This is the study "Alterations of the intestinal barrier in patients with autism spectrum disorders and in their first-degree relatives":
http://www.ncbi.nlm.nih.gov/pubmed/20683204
Which concludes:
NB. IPT = intestinal permeability.
Something particularly interesting is that "leaky gut"/higher IPT does not seem to be correlated with either celiac disease, ( as diagnosed by Ig tests or biopsy ), nor with GI symptoms. ie. there is no "big sign" ( of that sort ) to tell you that whenever you eat dairy and wheat/gluten your intestines are allowing opioid peptides to enter your bloodstream and reach your brain, ( significantly more than most/other people's intestines allow anyway ) ... ... ... except something to do with the opioids themselves, which is addiction; dependency on and cravings for foods with gluten and casein in them.
PS. This is a separate issue from celiac, crohns, IBS, and other chronic gastrointestinal problems, irritation/inflammation, etc, found in an increasingly large percentage of the population, ( an increase which may have something to do with the massive rise in fructose consumption ), and which obviously affects general functioning, peace of mind, etc, whether on the spectrum or not, aswell as often resulting in reduced absorption of important minerals and vitamins which impact on mental and physical health.
.
ie. more food opioid peptides, present in both gluten and casein, ( not just one of them ), are going to enter the bloodstream directly and reach the brain in that subset of people on the spectrum, ( more than a third of autists ), than in the general population.
Not only that, but that study and another one show that the gut/intestines are particularly leaky in the presence of gluten and casein, ( food opioid sources ), because of the effect that gluten has on the production of zonulin, which triggers intestinal cells to relax their "tight junctions" ( not sure about casein ).
This is quite a good article/blog piece on it by a psychiatrist:
http://evolutionarypsychiatry.blogspot. ... ism-1.html
This is the study "Alterations of the intestinal barrier in patients with autism spectrum disorders and in their first-degree relatives":
http://www.ncbi.nlm.nih.gov/pubmed/20683204
Which concludes:
Quote:
CONCLUSIONS: The results obtained support the leaky gut hypothesis and indicate that measuring IPT could help to identify a subgroup of patients with autism who could benefit from a gluten-[ and casein? ]-free diet. The IPT alterations found in first-degree relatives suggest the presence of an intestinal (tight-junction linked) hereditary factor in the families of subjects with autism.
NB. IPT = intestinal permeability.
Something particularly interesting is that "leaky gut"/higher IPT does not seem to be correlated with either celiac disease, ( as diagnosed by Ig tests or biopsy ), nor with GI symptoms. ie. there is no "big sign" ( of that sort ) to tell you that whenever you eat dairy and wheat/gluten your intestines are allowing opioid peptides to enter your bloodstream and reach your brain, ( significantly more than most/other people's intestines allow anyway ) ... ... ... except something to do with the opioids themselves, which is addiction; dependency on and cravings for foods with gluten and casein in them.
PS. This is a separate issue from celiac, crohns, IBS, and other chronic gastrointestinal problems, irritation/inflammation, etc, found in an increasingly large percentage of the population, ( an increase which may have something to do with the massive rise in fructose consumption ), and which obviously affects general functioning, peace of mind, etc, whether on the spectrum or not, aswell as often resulting in reduced absorption of important minerals and vitamins which impact on mental and physical health.
.
PS. I read today that there is a correlation between Crohn's disease and intestinal permeability however, and very intriguingly, that jewish people have 2-9 times the probability of having Crohn's than the wider population, which is particularly thought provoking when think how glutenous grains, with their food opioid peptides, first arose as a result of a grass mutation in the "Fertile Crescent" ( Eastern Turkey, Northern Iraq, the Middle East, etc ), and nowhere else, at the end of the last ice age, and how much attention is paid in the Koran/Old Testament to when dairy ( with its food opioid peptides ), may be eaten.
Good luck with your essay/project.
.
Last edited by ouinon on 24 Oct 2010, 6:29 am, edited 1 time in total.
24 Oct 2010, 6:22 am
And then there is also this study, also recent/publ online April 2010, also related to the theory ( whose principal proponents in Europe are Dr. Karl Reichelt and the Sunderland Project ), that people on the autism spectrum have particularly "leaky guts" and that this exposes them, their brains, to unusually large amounts of the food opioid peptides in gluten and dairy, and that this might have an influence on neural development/connections in the infant/immature brain, and on mood and cognitive functioning in the autistic adult.
Nutr Neurosci. 2010 Apr;13(2):87-100.
The ScanBrit randomised, controlled, single-blind study of a gluten- and casein-free dietary intervention for children with autism spectrum disorders.
Whiteley P, Haracopos D, Knivsberg AM, Reichelt KL, Parlar S, Jacobsen J, Seim A, Pedersen L, Schondel M, Shattock P.
Dept of Pharmacy, Health & Well-being, Faculty of Applied Sciences, University of Sunderland, UK. [email protected]
http://www.ncbi.nlm.nih.gov/pubmed/20406576
Quote:
Abstract:
There is increasing interest in the use of gluten- and casein-free diets for children with autism spectrum disorders (ASDs). We report results from a two-stage, 24-month, randomised, controlled trial incorporating an adaptive 'catch-up' design and interim analysis. Stage 1 of the trial saw 72 Danish children (aged 4 years to 10 years 11 months) assigned to diet (A) or non-diet (B) groups by stratified randomisation. Autism Diagnostic Observation Schedule (ADOS) and the Gilliam Autism Rating Scale (GARS) were used to assess core autism behaviours, Vineland Adaptive Behaviour Scales (VABS) to ascertain developmental level, and Attention-Deficit Hyperactivity Disorder - IV scale (ADHD-IV) to determine inattention and hyperactivity. Participants were tested at baseline, 8, and 12 months. Based on per protocol repeated measures analysis, data for 26 diet children and 29 controls were available at 12 months. At this point, there was a significant improvement to mean diet group scores (time*treatment interaction) on sub-domains of ADOS, GARS and ADHD-IV measures. Surpassing of predefined statistical thresholds as evidence of improvement in group A at 12 months sanctioned the re-assignment of group B participants to active dietary treatment. Stage 2 data for 18 group A and 17 group B participants were available at 24 months. Multiple scenario analysis based on inter- and intra-group comparisons showed some evidence of sustained clinical group improvements although possibly indicative of a plateau effect for intervention. Our results suggest that dietary intervention may positively affect developmental outcome for some children diagnosed with ASD. In the absence of a placebo condition to the current investigation, we are, however, unable to disqualify potential effects derived from intervention outside of dietary changes. Further studies are required to ascertain potential best- and non-responders to intervention. The study was registered with ClincialTrials.gov, number NCT00614198.PMID: 20406576 [PubMed - in process]
There is increasing interest in the use of gluten- and casein-free diets for children with autism spectrum disorders (ASDs). We report results from a two-stage, 24-month, randomised, controlled trial incorporating an adaptive 'catch-up' design and interim analysis. Stage 1 of the trial saw 72 Danish children (aged 4 years to 10 years 11 months) assigned to diet (A) or non-diet (B) groups by stratified randomisation. Autism Diagnostic Observation Schedule (ADOS) and the Gilliam Autism Rating Scale (GARS) were used to assess core autism behaviours, Vineland Adaptive Behaviour Scales (VABS) to ascertain developmental level, and Attention-Deficit Hyperactivity Disorder - IV scale (ADHD-IV) to determine inattention and hyperactivity. Participants were tested at baseline, 8, and 12 months. Based on per protocol repeated measures analysis, data for 26 diet children and 29 controls were available at 12 months. At this point, there was a significant improvement to mean diet group scores (time*treatment interaction) on sub-domains of ADOS, GARS and ADHD-IV measures. Surpassing of predefined statistical thresholds as evidence of improvement in group A at 12 months sanctioned the re-assignment of group B participants to active dietary treatment. Stage 2 data for 18 group A and 17 group B participants were available at 24 months. Multiple scenario analysis based on inter- and intra-group comparisons showed some evidence of sustained clinical group improvements although possibly indicative of a plateau effect for intervention. Our results suggest that dietary intervention may positively affect developmental outcome for some children diagnosed with ASD. In the absence of a placebo condition to the current investigation, we are, however, unable to disqualify potential effects derived from intervention outside of dietary changes. Further studies are required to ascertain potential best- and non-responders to intervention. The study was registered with ClincialTrials.gov, number NCT00614198.PMID: 20406576 [PubMed - in process]
And the same psychiatrist who blogged about the intestinal permeability study has looked at this one at:
http://evolutionarypsychiatry.blogspot. ... ism-2.html and had this to say:
EvolutionaryPsychiatry wrote:
The ScanBrit randomised, controlled, single-blind study of a gluten- and casein-free dietary intervention for children with autism spectrum disorders:
Published in Nutritional Neuroscience in April 2010, this study combined a lot of nice features.
It had a decent sample size - 72 Danish kids with ASDs (established by standard diagnostic criteria), and it was long - two years.
It had a sort of modified cross-over design. It was honest about being single blind - meaning the researchers (except the nutritionists) didn't know which kids were getting the special diets, but the parents (of course) knew. The kids' urine was tested for any abnormal metabolic byproducts.
Here's what the researchers did - for the first year, they put about half the kids on a gluten-free, casein-free diet and monitored their progress for 8 months. If the improvements in the kids on the diet were significantly better than the kids off the diet, they would extend the trial and put everyone on the GF-CF diet at 12 months, and monitor them for a total of 24 months (this is what happened in the actual trial - there was significant improvement in the study diet kids, and a worsening in the kids on the standard diet, so everyone was put on the study diet for the last 12 months). The researches used a battery of different tests, measuring a bunch of different subsets of autistic behaviors and ADHD symptoms at points along the trial. The results?
"Introducing a gluten-free, casein-free diet had a significant beneficial group effect at 8, 12, and 24 months of intervention on core autistic and related behaviors..." The improvement was less dramatic after the first 8 months, and could represent a plateau effect. Attentional and communication symptoms seemed to improve the most.
Published in Nutritional Neuroscience in April 2010, this study combined a lot of nice features.
It had a decent sample size - 72 Danish kids with ASDs (established by standard diagnostic criteria), and it was long - two years.
It had a sort of modified cross-over design. It was honest about being single blind - meaning the researchers (except the nutritionists) didn't know which kids were getting the special diets, but the parents (of course) knew. The kids' urine was tested for any abnormal metabolic byproducts.
Here's what the researchers did - for the first year, they put about half the kids on a gluten-free, casein-free diet and monitored their progress for 8 months. If the improvements in the kids on the diet were significantly better than the kids off the diet, they would extend the trial and put everyone on the GF-CF diet at 12 months, and monitor them for a total of 24 months (this is what happened in the actual trial - there was significant improvement in the study diet kids, and a worsening in the kids on the standard diet, so everyone was put on the study diet for the last 12 months). The researches used a battery of different tests, measuring a bunch of different subsets of autistic behaviors and ADHD symptoms at points along the trial. The results?
"Introducing a gluten-free, casein-free diet had a significant beneficial group effect at 8, 12, and 24 months of intervention on core autistic and related behaviors..." The improvement was less dramatic after the first 8 months, and could represent a plateau effect. Attentional and communication symptoms seemed to improve the most.
It is possible that if they had concentrated on the subset, the 36.7%/third of people on the spectrum with unusually "leaky guts"/higher than normal levels of intestinal permeability, the results would have been even more clearly in favour of gfcf diets, for 36.7% of us anyway.
.
24 Oct 2010, 10:03 am
PPS. Other, temporary, causes of increased intestinal permeability are inflammation, ( as in infection, auto-immune disorders ), non-alcoholic fatty liver disease/Metabolic Syndrome, and also a diet high in fructose, ( as in High-Fructose Corn Syrup, and other fructose based sweeteners ), which used to be relatively rare, but is now very common.
25 Oct 2010, 5:55 am
Zeldapsychology wrote:
If you guys can think of any Autism articles related to the above topics PM me or post a link in here please? Surely yall wouldn't mind helping me out a little please? Pretty please?
Have you decided what to write your "Current Event" piece about?
Were the links to studies/refs/quotes etc that I provided any use?
Good luck with writing the assignment!
.
26 Oct 2010, 5:12 am
26 Oct 2010, 5:35 am
StuartN wrote:
There is no conclusive scientific evidence that exclusions diets are beneficial for people with autism. There is a good blog piece at http://scienceblogs.com/insolence/2010/ ... sensus.php.
That blog piece was posted in January 2010, four months before both of the two studies that I referenced/quoted and linked to above were published!
Zeldapsychology is looking for material for a Current Events assignment, not old news!
.
26 Oct 2010, 11:27 am
ouinon wrote:
Zeldapsychology is looking for material for a Current Events assignment, not old news!
.
.
The most recent scientific study is The Gluten Free and Casein Free (GFCF) Diet: A Double Blind, Placebo Controlled Challenge Study http://imfar.confex.com/imfar/2010/webp ... r6183.html with good blog posts on http://leftbrainrightbrain.co.uk/2010/0 ... o-benefit/ and http://leftbrainrightbrain.co.uk/2010/0 ... nge-study/
New Scientist had several interesting articles about the dilemma facing parents of autistic children: Desperate measures: The lure of an autism cure http://www.newscientist.com/article/mg2 ... -cure.html Stop uncontrolled experiments on autistic children http://www.newscientist.com/article/mg2 ... ldren.html Autism and guilt http://www.newscientist.com/article/mg2 ... guilt.html (library may have back-issues, as these links are summary only).
26 Oct 2010, 11:37 am
26 Oct 2010, 11:40 am
26 Oct 2010, 11:42 am
OddFiction wrote:
No groundbreaking takes on it have surfaced in a while.
Please DO read my links, refs, and quotes above: the last six months has seen the publication of two groundbreaking studies done on the subject.
.
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