I think they are prime in ASD.
When you are very young and you realize that you make some mistakes without you knowing it, repeatedly, well it's very easy to start to question everything.
The only comfortable way out I know is to build things by asking yourself the right questions and if you can't get an answer directely, to make out loud (putting words is important) some supposition, put some probabilities on the possible outcomes. You'll always get one answer later in one form or another.