Autism and Schizophrenia might part of same disorder

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Autism and Schizophrenia part of same disorder?
yes 13%  13%  [ 3 ]
no 65%  65%  [ 15 ]
maybe 22%  22%  [ 5 ]
Total votes : 23

fie
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02 Sep 2020, 6:55 am

I thought it was important that I should cross-post this from the other board.
viewtopic.php?f=35&t=388969

TLDR> SSD and ASD are part of the same disorder. (most likely)

Quote:
"Schizo/Autism are spectrum disorders but I think they are the same spectrum just in a different dimension."


I feel like nobody understood this. If you didn't think of the spectrum being an X/Y chart then you got it wrong.

Saying "same spectrum" was probably bad wording but it was the best way I could think to describe it with just imagining this up while taking into consideration everything I know about both disorders. Now that I have done more research I can describe it better. They have the same underlying causes in relation to genetics and neurological development. It's all a matter of how your genes are expressed during brain development that determines which parts of each of the disorders you end up having. They both affect many similar parts of the brain but if those parts of the brain or under developed or over developed determines which spectrum symptom you have. It gets more intricate than that though, also the structure of these neurons in these parts of the brain can determine what symptoms you have.



Quote:
ASD and schizophrenia/psychosis have been proposed to be on two ends of a spectrum related to the social brain.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5906088/

Quote:
Conclusion: There is significant boundary overlap between autism spectrum disorder and schizophrenia spectrum disorder.

https://pubmed.ncbi.nlm.nih.gov/27311754/


This next article seems to indicate that SSD and ASD are highly related and that how the genes are expressed in different sections of the brain determines whether it's a schizophrenic symptom or autistic symptom.

Quote:
Evidence regarding the genetic, physiological, neurological, and psychological underpinnings of psychotic-spectrum conditions supports the hypothesis that the etiologies of these conditions involve biases towards increased relative effects from imprinted genes with maternal expression, which engender a general pattern of undergrowth. By contrast, autistic-spectrum conditions appear to involve increased relative bias towards effects of paternally expressed genes, which mediate overgrowth. This hypothesis provides a simple yet comprehensive theory, grounded in evolutionary biology and genetics, for understanding the causes and phenotypes of autistic-spectrum and psychotic-spectrum conditions.

https://pubmed.ncbi.nlm.nih.gov/18578904/

And this final one also confirms my original hypothesis that it's all the same sort of problem.
Quote:
Results: Cognitive performance analysis confirms the convergence of abnormalities of people with autism and people with schizophrenia on 1st and 2nd order theory of mind, emotion processing and social perception. Quantitative results show reduced performance in ASD compared to SZ and Ct groups. Differences were observed between ASD and SZ regarding social situation comprehension, visual orientation and visuospatial exploration strategies, and attributional style highlighting different strategies on intentional process. Brain imaging studies show that people with autism present a reduced cerebral activity in several key regions of theory of mind (cingulate regions, superior temporal sulcus, paracentral lobule), and emotional treatment (primary and secondary somatosensory regions), while people with SZ exhibit an inappropriate increased activity in these regions.

https://pubmed.ncbi.nlm.nih.gov/30122298/

It's like... how can everyone know that SSD and ASD have like 20 of the same genetic markers and not put the pieces of the puzzle together. SSD and ASD research teams need to be working together on this problem.

Image


And imagine the red corner having a strong repulsive force. The nature of the disorders involve the same areas of the brain but they whether they are over developed or under developed determines whether you have specific symptoms of each disorder. It is more common for all areas to be over-developed or under-developed but in some people there are a combination of both over and under developed parts.

NOTE:
this isn't proof, just an example of how to imagine them as the same disorder represented as 2 1 dimensional spectrums overlaid with each other in 2 dimensions.

I could be wrong, but I don't think I am.
<3



aquafelix
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02 Sep 2020, 7:03 am

Wasn't Leo Kanner's original theory that autism was a kind of infantile schizophrenia?



kraftiekortie
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02 Sep 2020, 7:22 am

I've known plenty of autistic people, and some schizophrenics, too.

No...they are not part of the same disorder.

Though "autism" was stated to be a characteristic of dementia praecox (schizophrenia) by Eugen Bleuler early in the 20th century.



fie
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02 Sep 2020, 7:56 am

kraftiekortie wrote:
I've known plenty of autistic people, and some schizophrenics, too.

No...they are not part of the same disorder.

Though "autism" was stated to be a characteristic of dementia praecox (schizophrenia) by Eugen Bleuler early in the 20th century.

You're taking a top down look at it. Look at it from inside the minds of those people. Not just the symptoms but why those symptoms exist. It's all in how the genes are expressed.



fie
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02 Sep 2020, 7:57 am

aquafelix wrote:
Wasn't Leo Kanner's original theory that autism was a kind of infantile schizophrenia?

I'm not sure that the reasoning for his hypothesis was correct.



kraftiekortie
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02 Sep 2020, 8:01 am

They are both neurologically-based conditions. And there are similarities.

But the schizophrenics I know, and the autistic folks I know, present quite differently. Different modalities are "impaired" within the two conditions. Autism, for example, can have intellectual disability as being one of the "symptoms." The prevalence is higher than within the general population.

In schizophrenia, intellectual disability is probably about as rare as it is in the general population.

Two closely-related conditions: What was once known as Asperger's Syndrome, and Nonverbal Learning Disability. It is said that there is an 80% overlap between them. However, one can have one without having the other.

I would not deny that there is overlap between schizophrenia and autism----but they are certainly two separate conditions, even if they happen to have an identical etiology (which they don't).



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02 Sep 2020, 8:04 am

Disorders of the brain can’t be neatly separated by thick steel walls.

Those diagnosises were invented in the mid 20th century or before when knowledge of the brain was non existent to tiny.

In the future maybe all born organic brain disorders will be simply labelled autism and then each broken down to its various disfunction?

The diagnosis “autism” is hardly a diagnosis in itself since it dates back to the 1940’s and there are many autism’s of varying severity that will one day in the future be broken up into their proper biological source with possible treatment options.


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aquafelix
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02 Sep 2020, 8:39 am

fie wrote:
aquafelix wrote:
Wasn't Leo Kanner's original theory that autism was a kind of infantile schizophrenia?

I'm not sure that the reasoning for his hypothesis was correct.

Yes. He was wrong. But Kanner also help start the "refrigerator mother" theory too. Also wrong, very wrong.



Fern
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02 Sep 2020, 11:19 am

fie wrote:
kraftiekortie wrote:
I've known plenty of autistic people, and some schizophrenics, too.

No...they are not part of the same disorder.

Though "autism" was stated to be a characteristic of dementia praecox (schizophrenia) by Eugen Bleuler early in the 20th century.

You're taking a top down look at it. Look at it from inside the minds of those people. Not just the symptoms but why those symptoms exist. It's all in how the genes are expressed.


What do you mean "why those symptoms exist"? We don't know the causes of autism. All we really know is that there is a genetic component, evidenced by autism seeming to run in families. Admittedly, schizophrenia does also run in families, but then again, so do unibrows. No one is saying that unibrows and schizophrenia are on the same spectrum.

As for what are going on in people's heads, to me, that seems to be the most different of all. Autistic people don't typically suffer from hallucinations or paranoid delusions for instance. Although these diagnoses share a breakdown of functioning observable from the outside, they are driven by different things.

The DSM addresses this "If there is a history of autism spectrum disorder or a communication disorder of childhood onset, the additional diagnosis of schizophrenia is made only if prominent delusions or hallucinations, in addition to the other required symptoms or schizophrenia are also present for at least 1 month (or less if successfully treated)"

The experience of people with both conditions is valid, but is not necessarily the norm for everyone else.



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02 Sep 2020, 2:17 pm

I am currently diagnosed with both Asperger syndrome and schizotypal disorder (according to ICD-10). In ICD-10 schizophrenia-type disorder (F21) is not a personality disorder as in DSM, but is a mental illness from the same part of ICD-10 classification as schizophrenia or schizoaffective disorder. I had diagnosis of schizophrenia (not just schizotypal disorder) for a short time in 2016. I have never had diagnoses of schizophrenia (F20) and PDD (F84) at the same time, only schizotypal disorder with PDD together.

PDD/ASD and schizo disorders have quite similar symptoms in some areas (poor social functioning, atypical emotionality, being considered "odd", "weird" by many people etc.). So, according to my diagnoses which I have since more than four years, I have "double mental peculiarity". I have also severe, bookish case of OCD. I function in adult life really poorly despite the fact that I was pretty good in academic skills and Wechsler IQ test (in many subscales).

My theory: maybe some cases of PDD/ASD and schizo disorders are not "pure" or typical ASDs or just standard schizo conditions (people who have schizophrenia can be mentally "normal" in childhood, while those with ASD/PDD always show peculiarity in childhood), but PDDs from the schizo continuum (and probably not from "normal" autistic spectrum)?



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03 Sep 2020, 3:35 am

fie wrote:
I thought it was important that I should cross-post this from the other board.
viewtopic.php?f=35&t=388969

TLDR> SSD and ASD are part of the same disorder. (most likely)

Quote:
"Schizo/Autism are spectrum disorders but I think they are the same spectrum just in a different dimension."


I feel like nobody understood this. If you didn't think of the spectrum being an X/Y chart then you got it wrong.

Saying "same spectrum" was probably bad wording but it was the best way I could think to describe it with just imagining this up while taking into consideration everything I know about both disorders. Now that I have done more research I can describe it better. They have the same underlying causes in relation to genetics and neurological development. It's all a matter of how your genes are expressed during brain development that determines which parts of each of the disorders you end up having. They both affect many similar parts of the brain but if those parts of the brain or under developed or over developed determines which spectrum symptom you have. It gets more intricate than that though, also the structure of these neurons in these parts of the brain can determine what symptoms you have.



Quote:
ASD and schizophrenia/psychosis have been proposed to be on two ends of a spectrum related to the social brain.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5906088/

Quote:
Conclusion: There is significant boundary overlap between autism spectrum disorder and schizophrenia spectrum disorder.

https://pubmed.ncbi.nlm.nih.gov/27311754/


This next article seems to indicate that SSD and ASD are highly related and that how the genes are expressed in different sections of the brain determines whether it's a schizophrenic symptom or autistic symptom.

Quote:
Evidence regarding the genetic, physiological, neurological, and psychological underpinnings of psychotic-spectrum conditions supports the hypothesis that the etiologies of these conditions involve biases towards increased relative effects from imprinted genes with maternal expression, which engender a general pattern of undergrowth. By contrast, autistic-spectrum conditions appear to involve increased relative bias towards effects of paternally expressed genes, which mediate overgrowth. This hypothesis provides a simple yet comprehensive theory, grounded in evolutionary biology and genetics, for understanding the causes and phenotypes of autistic-spectrum and psychotic-spectrum conditions.

https://pubmed.ncbi.nlm.nih.gov/18578904/

And this final one also confirms my original hypothesis that it's all the same sort of problem.
Quote:
Results: Cognitive performance analysis confirms the convergence of abnormalities of people with autism and people with schizophrenia on 1st and 2nd order theory of mind, emotion processing and social perception. Quantitative results show reduced performance in ASD compared to SZ and Ct groups. Differences were observed between ASD and SZ regarding social situation comprehension, visual orientation and visuospatial exploration strategies, and attributional style highlighting different strategies on intentional process. Brain imaging studies show that people with autism present a reduced cerebral activity in several key regions of theory of mind (cingulate regions, superior temporal sulcus, paracentral lobule), and emotional treatment (primary and secondary somatosensory regions), while people with SZ exhibit an inappropriate increased activity in these regions.

https://pubmed.ncbi.nlm.nih.gov/30122298/

It's like... how can everyone know that SSD and ASD have like 20 of the same genetic markers and not put the pieces of the puzzle together. SSD and ASD research teams need to be working together on this problem.

Image


And imagine the red corner having a strong repulsive force. The nature of the disorders involve the same areas of the brain but they whether they are over developed or under developed determines whether you have specific symptoms of each disorder. It is more common for all areas to be over-developed or under-developed but in some people there are a combination of both over and under developed parts.

NOTE:
this isn't proof, just an example of how to imagine them as the same disorder represented as 2 1 dimensional spectrums overlaid with each other in 2 dimensions.

I could be wrong, but I don't think I am.
<3

I think a sarcastic approach would be bet with this
Yes two disorders that are completely different in everyway are the same disorder How did yo find out!? :lol: Just because similiar things mgiht be causing them doesn't mean tehy are the same thing. Hey chronic abuse can cause both DID and PTSD they must be the same thing. Like come on man this absurd


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03 Sep 2020, 5:16 am

A thought occurred to me that when I saw some replies, some were giving examples and others were saying how the people had their theories wrong.
But something came to me that the wrong theories were just as important as the right ones because without the wrong ones in place, one has nothing to think about to reach the more accurate "Right" conclusions. (I say "Right" knowing that there still yet may be more adjustments made in future theories and conclusions).
It is a brave thing to come out with a theory knowing that it will be torn apart and likely to be reformed or re-assembled etc in other ways. I think we need to recognize that every theory put forward was a step forward in our understanding be the theories right or wrong.
As I get older I am learning to value all the steps in the process. For example, something simple like making model railway waggons and carriages. It took me many attempts before I was happy with the designs and some have further experimentations and ideas to explore. Without trying things out I would not have known what works and what does not.
Theories can also be like this. Someone has an idea. They are brave enough to share it. Others look at it to see if the idea is what they see happening in the real world and report back... It is all needed in the process of discovering the truth. (And even when we think we have discovered it we may have to makeammendmwnts to it as we go along!)



fie
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04 Sep 2020, 12:20 am

Fern wrote:
What do you mean "why those symptoms exist"? We don't know the causes of autism. All we really know is that there is a genetic component, evidenced by autism seeming to run in families.


Yes we don't know the "cause" of Autism and neither do we know the cause of Schizophrenia. We know there's a strong genetic component and has to do with gene expression. We also know the areas of the brain effected.

Autism and Schizophrenia share many of the same genetic markers and both affect the brain in most of the same regions.

There are identical twins and only one has autism.

"The researchers found that the gene expression signatures in the autism brains overlap with those of both the schizophrenia and bipolar disorder brains."

The "why those symptoms exist" is in reference to why identical sets of genes can cause one person to have autism and the other to not. What is the mechanism in the brain that causes it to start not growing right. Also after the autistic brain develops what is the underlying action in the brain between neurons and neurotransmitters that causes the symptoms.

Fern wrote:

Admittedly, schizophrenia does also run in families, but then again, so do unibrows. No one is saying that unibrows and schizophrenia are on the same spectrum.


This tells me that you didn't read any of my references. Unibrows run in families, schizophrenia run in families. How many genetic markers do Unibrows and Schizophrenia share?

Autism and Schizophrenia share 21 genetic markers. https://www.ncbi.nlm.nih.gov/pmc/articl ... objectonly



fie
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Joe90
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23 Sep 2020, 10:57 am

So I'm Schizophrenic now too. :roll:


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23 Sep 2020, 11:03 am

Joe90 wrote:
So I'm Schizophrenic now too. :roll:
Your post reminded me of an old joke/poem...
Quote:
Roses are red
Violets are blue
I'm schizophrenic
And so am I!
It makes no sense, but then again, no proper birdwhistle would die for a grapefruit ... amiright?