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MotherKnowsBest
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19 Sep 2011, 11:56 am

I need some help from science brains with this issue.

I've been drawn into an argument with a group of NT women I know who keep perpetuating the notion that vaccines cause autism. I should just leave them to it, but for some reason this really offends me and I can't let it go. One of them is now telling the others that I don't know what I'm talking about and citing the paper linked below as proof of the link between thimerosal in vaccines and autism. I feel like they are trying to tie me up in knots and bury me under science that I doubt even they understand.

Can anyone more able in this field tell me whether the claim that this article shows a link between vaccines and autism is correct or not. If it doesn't, can you explain? Thanks.

http://www.autismus-ads-behandeln.ch/ad ... 0-%202.pdf



ValentineWiggin
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19 Sep 2011, 12:04 pm

At first glance, the paper's title suggests the study concluded the neuro-toxin effects of compounds found in vaccines are restricted to certain breeds of mice, based on varying levels of auto-immunity. So, already, we're not looking at vaccines, we're looking at vaccines-when-given-to-certain-individuals.

It would seem to me the extrapolative ramifications for developing human brains is...dubious, at best.

More importantly, why would these women conclude the vaccine is responsible, as opposed to the differences in auto-immunity and some third, endogenous variable?

Do these ignoramuses think Autism can only be observed in industrialized countries (with vaccines)? :lol:

Here's the real gem:

"The human study was not
designed to measure pharmacokinetic parameters
and missed important early sampling times, leading
to possible underestimates of maximal infant exposures.
Neither study had sample size sufficient to
investigate toxicity as a function of heritable influences.."


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Last edited by ValentineWiggin on 19 Sep 2011, 12:13 pm, edited 1 time in total.

MotherKnowsBest
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19 Sep 2011, 12:11 pm

They think that autism has different causes, which I find a bit weird because surely that would mean they are different conditions. :? I'm not confident enough in my own knowledge to stand up to them, but at the same time feel disloyal to myself as an autistic person if I ignore it.



ValentineWiggin
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19 Sep 2011, 12:15 pm

MotherKnowsBest wrote:
They think that autism has different causes, which I find a bit weird because surely that would mean they are different conditions. :? I'm not confident enough in my own knowledge to stand up to them, but at the same time feel disloyal to myself as an autistic person if I ignore it.


Tell them to come back when they read up on what Autism actually *is*
it's prevalence around the world, (it also occurs in non-industrialized countries wherein vaccines are not standard)
and HAVE A STUDY INVOLVING HUMANS.

They sound like a nutty bunch of Autism Speaks groupies.


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MotherKnowsBest
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19 Sep 2011, 12:19 pm

They're a group of mums who don't think they should sacrifice their own children to autism by vaccinating them for the greater good of those who cannot be vaccinated. And of course they know someone whose child was perfectly fine until they had their vaccinations and now has severe autism and I'm insulting them by insisting there is no link.



ooOoOoOAnaOoOoOoo
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19 Sep 2011, 12:19 pm

The study mentions environmental susceptibility genes which means there is a genetic component. It is possible the toxin load threshold could be much lower in people with these genes. To me it doesn't sound unreasonable. Living creatures are susceptible to changes in their environment. It can trigger mutations in genes or can cause some genes not to function properly. Right?



MotherKnowsBest
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19 Sep 2011, 12:28 pm

I found the article below which says that there is no link, which came after the one they sent me. I'm trying to get my head around the opposing positions. Is it as ValentineWiggin said, the first was on mice whereas this one refers to research done on humans? So it doesn't matter what the mice one says because the research involving humans shows no link? Sorry, I don't mean to be dim.

http://cid.oxfordjournals.org/content/48/4/456.full



ElfMusic
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19 Sep 2011, 12:35 pm

Thimerasol has not been in children's vaccines for years. If thimerasol was a cause, we would have seen a drop in autism rates in the years since it has been discontinued in children's vaccines (as advocates of this hypothesis publicly predicted.) As this has not been the case, thimerasol has been effectively ruled out as a causative factor.

Two books I would recommend to give you a better background are:

Autism's False Prophets: Bad Science, Risky Medicine, and the Search for a Cure by Paul Offit, that discusses much of the bad science among the anti-vax crowd and how they have made lucrative businesses out of promoting these.

The other is Unstrange Minds: Re-Mapping the World of Autism by Richard Roy Grinker, an anthropologist who looks at perceptions of autism in different cultures. Of particular importance is his explanation of the changing diagnostic criteria to demonstrate that autism diagnoses are increasing, but autistic people have been around for human history, thus negating the whole "autism epidemic" claims that underlie most of the ant-vax movement.

If these people actually want to base their beliefs on data, there is a lot of good material from these two books you could share with them. If they're just looking for data to support what they have already decided to believe (which is a form of religion or politics, not science) then they are probably not worth speaking with in the first place.



ooOoOoOAnaOoOoOoo
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19 Sep 2011, 12:38 pm

Quote:
Major histocompatibility complex
(MHC) genes regulate risk of mercury-induced
autoimmunity in mice.
18,19
To examine whether immunogenetic factors mediate vulnerability to
mercury-related neurodevelopmental damage, we
exposed mice of differing MHC (H-2) backgrounds
20
to thimerosal in doses and timing equivalent to the
pediatric immunization schedule. Profound behavioral and neuropathologic disturbances were observed
after postnatal thimerosal in SJL/J (H-2
s
) mice, but not
in strains without autoimmune sensitivity (BALB/cJ,
H-2
d
, or C57BL/6J, H
b
mice).

Believe what you want but looking at this study objectively, it suggests there was a response in mice with MHC genetic issues and not in mice without these same issues.
Just because you disagree in principal with this study or its results doesn't mean you should discard its validity completely. It is just one study and these are the results from this one study.



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19 Sep 2011, 1:06 pm

ask them this:

"does it make sense that medicine would cause people to get developmental problems?"


if they say yes then they probably would believe anything they read on the news :/



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19 Sep 2011, 1:14 pm

Quote:
Researcher Behind Debunked Autism-Vaccine Study Stood To Make Millions
By Michelle Diament

January 12, 2011

A week after calling research that first suggested a link between autism and vaccines an “elaborate fraud” a follow-up article in the British Medical Journal now says the researcher behind the study planned to make upwards of $43 million annually selling replacement vaccines and diagnostic products.

In the report published Tuesday, journalist Brian Deer reveals that Andrew Wakefield held a patent for “a ‘safer’ single measles shot.”

Meanwhile, Deer reports that Wakefield was in talks with investors to develop a business that “was to be launched off the back of the vaccine scare, diagnosing a purported — and still unsubstantiated — ‘new syndrome.’” A business plan for the venture indicates that by year three, diagnostic kits alone were anticipated to garner $43 million per year.

Among Wakefield’s business partners was the father of one of the children in the original study, Deer found.

The new information casts further doubt on the credibility of Wakefield who set off a worldwide vaccine scare with his 1998 study in the journal The Lancet which first suggested a link between autism and the measles, mumps and rubella, or MMR, vaccine.

Amid numerous questions about the study, The Lancet retracted Wakefield’s paper last year just months before his British medical license was stripped.

Deer reports this week that Wakefield was asked by his superiors at the University College London in 1999 to replicate his study using a larger sampling of 150 children after they expressed concerns about a “serious conflict of interest” given his business plans.

But Wakefield did not pursue further study on the matter and ultimately left the institution, with his boss saying, “we paid him to go away.”



Copyright © 2011 Disability Scoop, LLC. All Rights Reserved.


Science! :roll:



ooOoOoOAnaOoOoOoo
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19 Sep 2011, 1:27 pm

How can anyone know where the truth lies when everyone has something to gain? They aren't going to be objective when millions if not billions of dollars are at stake.

Face it, everyone has something to sell.

Perhaps much bio science is flawed because of this startling realization.

This is why objectivity and careful scrutiny not to mention research (but I did anyway) is paramount!



ValentineWiggin
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19 Sep 2011, 1:40 pm

Dgosling wrote:
ask them this:

"does it make sense that medicine would cause people to get developmental problems?"


if they say yes then they probably would believe anything they read on the news :/


Countless drugs cause countless more adverse reactions up to and including death annually,
to the tune of thousands upon thousands of people.

To think "medicine" is sacrosanct because it's supposed to help a perceived problem is the far more naive view.


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ValentineWiggin
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19 Sep 2011, 1:43 pm

I cannot wait until the day people stop calling a few money-hungry, intellectually-dishonest holders of science degrees "science".


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Dgosling
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19 Sep 2011, 1:43 pm

ValentineWiggin wrote:
Dgosling wrote:
ask them this:

"does it make sense that medicine would cause people to get developmental problems?"


if they say yes then they probably would believe anything they read on the news :/


Countless drugs cause countless more adverse reactions up to and including death annually,
to the tune of thousands upon thousands of people.

To think "medicine" is sacrosanct because it's supposed to help a perceived problem is the far more naive view.


i know that but i don't think it's possible for any type of medicine to cause developmental problems. It just seems impossible to me :/



ValentineWiggin
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19 Sep 2011, 1:44 pm

Dgosling wrote:
i know that but i don't think it's possible for any type of medicine to cause developmental problems. It just seems impossible to me :/

Uh...why? :?
Virtually anything, genetic or environmental, stands to affect development if it interferes with regulatory bodily processes or brain activity,
that is to say,
ALMOST ALL MEDICINE.


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They talk and vote as they are directed by Some Man of Property, who has attached their Minds
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