I'm pretty sure that I'm the only autistic person in the family. Likely the only one, including those many distant relatives, with official psychiatric diagnoses even.
Not sure about the few toddlers and small children I'm distantly related with or those who I assume will have babies in the not-so-far future though. After all, I ended up being autistic, so who knows if it will happen again.
Of course, someone long-dead might have had it, but I have no definite clues to work on so that's merely guesswork.
Other families I know with autistic children or adults have more than one relative on the spectrum or with autistic traits.
Doing a quick run down in my head to be sure, but yeah, that's right, everyone I happened to get to know so far has a child or a parent with an ASD or with broader autism phenotype.
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Autism + ADHD
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The trouble with having an open mind, of course, is that people will insist on coming along and trying to put things in it. Terry Pratchett