I'm kind of surprised no one's mentioned mine yet.
My biggest liability - which I've been carrying with me all of my life - is that people can't read me accurately and, when they cant it mostly veers negative. That puts me also in the uncomfortable position of socially knowing what I need to do but also knowing that I personally am not allowed to do it because it won't register right - hence I'm caught in an eternal catch-22. No matter what I improve about myself, change about myself, learn, improve in awareness, I'm still coming off as something very much other than NT. There's really nothing I can do about it, I have close friends, can hold a good job so long as the people I work for are more concerned about character and performance than rote social skills, but my social skills fall apart not from lack of knowledge but because I simply cannot do what the next person does and expect the same reaction or outcome.
The best way I can explain it: on one side my facial expressions ring weird and hollow, on another - there are literally things I cannot do behaviorally, no matter how well I understand them in others.
I'll have to see what other answers this post gets. I suppose mine might perhaps do the most in the 'traditional lifestyle' damage category (ie. I'm pretty sure - no matter how normal I fundamentally am I'll never be married, never have kids, may never have a relationship longer than a month) but doesn't do a wild amount of damage to hireablility or friendships so perhaps each of those categories will get hit harder by a different ASD trait. Should be interesting.
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The loneliest part of life: it's not just that no one is on your cloud, few can even see your cloud.