Definitely; I mean, I'm a fantastic driver - no tickets, no accidents and always incredibly acutely aware of things going on around me but it IS extremely exhausting. In order to drive, I feel like my brain has to be firing on absolutely all cylinders, all the time and on the occasions that I do feel like I can relax (long freeway trips), I find it difficult to force myself back into that high-concentration mode once I've gotten off the freeway and usually have to stop and sort of re-gather myself. Agreed roundabouts, four way stops, merging with other people: all of that stuff causes a bit of anxiety for me. I can't say definitively if this is related to Asperger's since I'm certainly not qualified to make such statements but I think that people on the spectrum who are very detail oriented, are likely to find all of the sensory (visual, sometimes auditory, etc.) stimulation of driving, very overwhelming. As far as dealing with it - I try to take the exact same routes everywhere to help alleviate the issue but the primary way I deal with it, is to either avoid driving when possible or carpool often; both are coping out (though carpooling is great for the environment, woot) and I wish I had the motivation to work on the problem rather than avoid it.